Overexpression of different members of the type 1 growth factor receptor family and their association with cell proliferation in periampullary carcinoma

Pradeep Vaidya, Yoshifumi Kawarada, Takashi Higashiguchi, Toshimichi Yoshida, Teruyo Sakakura, Ryuichi Yatani

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Abstract

The expression of epidermal growth factor receptor (EGFR), c-erbB-2, and c-erbB-3 was examined immunohistochemically in 57 cases of periampullary carcinoma. The percentage of Ki-67-positive cells was also examined in the same tissue, to determine the relationship between the expression of the members of the type 1 growth factor receptor family and cell proliferation. In carcinoma of the head of pancreas, the percentage of cases with overexpression of c-erbB3 was significantly higher than with overexpression of c-erbB-2 and EGFR. In contrast, in lower bile duct carcinoma and carcinoma of the ampulla of Vater, the percentages of cases with overexpression of c-er6B-2 was greater than with overexpression of other growth factor receptors. A higher percentage of cases with overexpression of c-erbB-3 in pancreatic head carcinoma and overexpression of c-erbB-2 in carcinoma of the ampulla of Vater was found in Ki-67 antigen-positive cases. Moreover, the overexpression of c-erb-3 in pancreatic head carcinoma, c-erb-2 in ampulla of Vater carcinoma, and Ki-67 in both carcinomas was found to be associated with poor patient outcome. These results demonstrate that different members of the type 1 growth factor receptor family are overexpressed in different carcinomas of the periampullary region.

Original languageEnglish
Pages (from-to)140-145
Number of pages6
JournalJournal of Pathology
Volume178
Issue number2
DOIs
Publication statusPublished - 20-02-1996
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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