Overexpression of different members of the type 1 growth factor receptor family and their association with cell proliferation in periampullary carcinoma

Pradeep Vaidya, Yoshifumi Kawarada, Takashi Higashiguchi, Toshimichi Yoshida, Teruyo Sakakura, Ryuichi Yatani

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The expression of epidermal growth factor receptor (EGFR), c-erbB-2, and c-erbB-3 was examined immunohistochemically in 57 cases of periampullary carcinoma. The percentage of Ki-67-positive cells was also examined in the same tissue, to determine the relationship between the expression of the members of the type 1 growth factor receptor family and cell proliferation. In carcinoma of the head of pancreas, the percentage of cases with overexpression of c-erbB3 was significantly higher than with overexpression of c-erbB-2 and EGFR. In contrast, in lower bile duct carcinoma and carcinoma of the ampulla of Vater, the percentages of cases with overexpression of c-er6B-2 was greater than with overexpression of other growth factor receptors. A higher percentage of cases with overexpression of c-erbB-3 in pancreatic head carcinoma and overexpression of c-erbB-2 in carcinoma of the ampulla of Vater was found in Ki-67 antigen-positive cases. Moreover, the overexpression of c-erb-3 in pancreatic head carcinoma, c-erb-2 in ampulla of Vater carcinoma, and Ki-67 in both carcinomas was found to be associated with poor patient outcome. These results demonstrate that different members of the type 1 growth factor receptor family are overexpressed in different carcinomas of the periampullary region.

Original languageEnglish
Pages (from-to)140-145
Number of pages6
JournalJournal of Pathology
Volume178
Issue number2
DOIs
Publication statusPublished - 20-02-1996
Externally publishedYes

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Growth Factor Receptors
Cell Proliferation
Carcinoma
Ampulla of Vater
Epidermal Growth Factor Receptor
Ki-67 Antigen
Bile Ducts
Pancreas

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Vaidya, Pradeep ; Kawarada, Yoshifumi ; Higashiguchi, Takashi ; Yoshida, Toshimichi ; Sakakura, Teruyo ; Yatani, Ryuichi. / Overexpression of different members of the type 1 growth factor receptor family and their association with cell proliferation in periampullary carcinoma. In: Journal of Pathology. 1996 ; Vol. 178, No. 2. pp. 140-145.
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Overexpression of different members of the type 1 growth factor receptor family and their association with cell proliferation in periampullary carcinoma. / Vaidya, Pradeep; Kawarada, Yoshifumi; Higashiguchi, Takashi; Yoshida, Toshimichi; Sakakura, Teruyo; Yatani, Ryuichi.

In: Journal of Pathology, Vol. 178, No. 2, 20.02.1996, p. 140-145.

Research output: Contribution to journalArticle

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