Overexpression of MCT8 enhances the differentiation of ES cells into neural progenitors

Mika Sugiura, Masato Nagaoka, Hikaru Yabuuchi, Toshihiro Akaike

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Embryonic stem (ES) cell differentiation is regulated by cytokines and growth factors, as well as small-compound chemicals incorporated into cells by transporter proteins. Little is known regarding the effect of transporters on ES cell differentiation. This study focused on the effect of transporters during the neural-lineage differentiation of ES cells. Among the 27 types of SLC family transporters, MCT8 expression was coincident with that of neural stem cell markers, and the overexpression of MCT8 accelerated the differentiation into neural cells. These results suggested that the transporters and their substrates also play a crucial role in the regulation of ES cell differentiation.

Original languageEnglish
Pages (from-to)741-745
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume360
Issue number4
DOIs
Publication statusPublished - 07-09-2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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