TY - JOUR
T1 - Overexpression of MCT8 enhances the differentiation of ES cells into neural progenitors
AU - Sugiura, Mika
AU - Nagaoka, Masato
AU - Yabuuchi, Hikaru
AU - Akaike, Toshihiro
N1 - Funding Information:
We thank Prof. Hitoshi Niwa of the RIKEN Center for Developmental Biology for his generous gifts of ES cell lines (EB3 cells and MG1.19 cells) and episomal expression vector pHPCAG. This work was supported by a Grant of the 21st Century COE Program and a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan.
PY - 2007/9/7
Y1 - 2007/9/7
N2 - Embryonic stem (ES) cell differentiation is regulated by cytokines and growth factors, as well as small-compound chemicals incorporated into cells by transporter proteins. Little is known regarding the effect of transporters on ES cell differentiation. This study focused on the effect of transporters during the neural-lineage differentiation of ES cells. Among the 27 types of SLC family transporters, MCT8 expression was coincident with that of neural stem cell markers, and the overexpression of MCT8 accelerated the differentiation into neural cells. These results suggested that the transporters and their substrates also play a crucial role in the regulation of ES cell differentiation.
AB - Embryonic stem (ES) cell differentiation is regulated by cytokines and growth factors, as well as small-compound chemicals incorporated into cells by transporter proteins. Little is known regarding the effect of transporters on ES cell differentiation. This study focused on the effect of transporters during the neural-lineage differentiation of ES cells. Among the 27 types of SLC family transporters, MCT8 expression was coincident with that of neural stem cell markers, and the overexpression of MCT8 accelerated the differentiation into neural cells. These results suggested that the transporters and their substrates also play a crucial role in the regulation of ES cell differentiation.
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U2 - 10.1016/j.bbrc.2007.06.109
DO - 10.1016/j.bbrc.2007.06.109
M3 - Article
C2 - 17624308
AN - SCOPUS:34447542833
VL - 360
SP - 741
EP - 745
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 4
ER -