Overexpression of piccolo C2A domain induces depression-like behavior in mice

Yoko Furukawa-Hibi, Atsumi Nitta, Hidefumi Fukumitsu, Hitomi Somiya, Shoei Furukawa, Toshitaka Nabeshima, Kiyofumi Yamada

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Piccolo is one of the components of the active zone at chemical synapses and regulates the transport of synaptic vesicles. The piccolo C2A domain is an important calcium sensor and binds with phosphatidylinositol or synaptotagmin-1. Recently, clinical studies suggested that a single nucleotide polymorphism in the piccolo C2A domain might be a causal risk factor for major depression. To clarify the association of piccolo with depression, we produced a transgenic mouse overexpressing the C2A domain of piccolo, and investigated the behavior of these mice. The mice exhibited depression-like behavior in both forced swim and tail suspension tests, suggesting that piccolo might regulate the depressive behavior.

Original languageEnglish
Pages (from-to)1177-1181
Number of pages5
JournalNeuroReport
Volume21
Issue number18
DOIs
Publication statusPublished - 29-12-2010
Externally publishedYes

Fingerprint

Depression
Synaptotagmin I
Hindlimb Suspension
Transport Vesicles
Synaptic Vesicles
Phosphatidylinositols
Synapses
Transgenic Mice
Single Nucleotide Polymorphism
Calcium
Clinical Studies

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Furukawa-Hibi, Y., Nitta, A., Fukumitsu, H., Somiya, H., Furukawa, S., Nabeshima, T., & Yamada, K. (2010). Overexpression of piccolo C2A domain induces depression-like behavior in mice. NeuroReport, 21(18), 1177-1181. https://doi.org/10.1097/WNR.0b013e3283411685
Furukawa-Hibi, Yoko ; Nitta, Atsumi ; Fukumitsu, Hidefumi ; Somiya, Hitomi ; Furukawa, Shoei ; Nabeshima, Toshitaka ; Yamada, Kiyofumi. / Overexpression of piccolo C2A domain induces depression-like behavior in mice. In: NeuroReport. 2010 ; Vol. 21, No. 18. pp. 1177-1181.
@article{10308e73f62249cb9ce9674fb212e8cb,
title = "Overexpression of piccolo C2A domain induces depression-like behavior in mice",
abstract = "Piccolo is one of the components of the active zone at chemical synapses and regulates the transport of synaptic vesicles. The piccolo C2A domain is an important calcium sensor and binds with phosphatidylinositol or synaptotagmin-1. Recently, clinical studies suggested that a single nucleotide polymorphism in the piccolo C2A domain might be a causal risk factor for major depression. To clarify the association of piccolo with depression, we produced a transgenic mouse overexpressing the C2A domain of piccolo, and investigated the behavior of these mice. The mice exhibited depression-like behavior in both forced swim and tail suspension tests, suggesting that piccolo might regulate the depressive behavior.",
author = "Yoko Furukawa-Hibi and Atsumi Nitta and Hidefumi Fukumitsu and Hitomi Somiya and Shoei Furukawa and Toshitaka Nabeshima and Kiyofumi Yamada",
year = "2010",
month = "12",
day = "29",
doi = "10.1097/WNR.0b013e3283411685",
language = "English",
volume = "21",
pages = "1177--1181",
journal = "NeuroReport",
issn = "0959-4965",
publisher = "Lippincott Williams and Wilkins",
number = "18",

}

Furukawa-Hibi, Y, Nitta, A, Fukumitsu, H, Somiya, H, Furukawa, S, Nabeshima, T & Yamada, K 2010, 'Overexpression of piccolo C2A domain induces depression-like behavior in mice', NeuroReport, vol. 21, no. 18, pp. 1177-1181. https://doi.org/10.1097/WNR.0b013e3283411685

Overexpression of piccolo C2A domain induces depression-like behavior in mice. / Furukawa-Hibi, Yoko; Nitta, Atsumi; Fukumitsu, Hidefumi; Somiya, Hitomi; Furukawa, Shoei; Nabeshima, Toshitaka; Yamada, Kiyofumi.

In: NeuroReport, Vol. 21, No. 18, 29.12.2010, p. 1177-1181.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Overexpression of piccolo C2A domain induces depression-like behavior in mice

AU - Furukawa-Hibi, Yoko

AU - Nitta, Atsumi

AU - Fukumitsu, Hidefumi

AU - Somiya, Hitomi

AU - Furukawa, Shoei

AU - Nabeshima, Toshitaka

AU - Yamada, Kiyofumi

PY - 2010/12/29

Y1 - 2010/12/29

N2 - Piccolo is one of the components of the active zone at chemical synapses and regulates the transport of synaptic vesicles. The piccolo C2A domain is an important calcium sensor and binds with phosphatidylinositol or synaptotagmin-1. Recently, clinical studies suggested that a single nucleotide polymorphism in the piccolo C2A domain might be a causal risk factor for major depression. To clarify the association of piccolo with depression, we produced a transgenic mouse overexpressing the C2A domain of piccolo, and investigated the behavior of these mice. The mice exhibited depression-like behavior in both forced swim and tail suspension tests, suggesting that piccolo might regulate the depressive behavior.

AB - Piccolo is one of the components of the active zone at chemical synapses and regulates the transport of synaptic vesicles. The piccolo C2A domain is an important calcium sensor and binds with phosphatidylinositol or synaptotagmin-1. Recently, clinical studies suggested that a single nucleotide polymorphism in the piccolo C2A domain might be a causal risk factor for major depression. To clarify the association of piccolo with depression, we produced a transgenic mouse overexpressing the C2A domain of piccolo, and investigated the behavior of these mice. The mice exhibited depression-like behavior in both forced swim and tail suspension tests, suggesting that piccolo might regulate the depressive behavior.

UR - http://www.scopus.com/inward/record.url?scp=78650513720&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78650513720&partnerID=8YFLogxK

U2 - 10.1097/WNR.0b013e3283411685

DO - 10.1097/WNR.0b013e3283411685

M3 - Article

VL - 21

SP - 1177

EP - 1181

JO - NeuroReport

JF - NeuroReport

SN - 0959-4965

IS - 18

ER -

Furukawa-Hibi Y, Nitta A, Fukumitsu H, Somiya H, Furukawa S, Nabeshima T et al. Overexpression of piccolo C2A domain induces depression-like behavior in mice. NeuroReport. 2010 Dec 29;21(18):1177-1181. https://doi.org/10.1097/WNR.0b013e3283411685