TY - JOUR
T1 - Overexpression of rck/p54, a DEAD box protein, in human colorectal tumours
AU - Nakagawa, Y.
AU - Morikawa, H.
AU - Hirata, I.
AU - Shiozaki, M.
AU - Matsumoto, A.
AU - Maemura, K.
AU - Nishikawa, T.
AU - Niki, M.
AU - Tanigawa, N.
AU - Ikegami, M.
AU - Katsu, K.
AU - Akao, Y.
N1 - Funding Information:
This work was supported in part by a grant-in-aid for scientific research from the Ministry of Education, Science, Sports and Culture of Japan.
PY - 1999
Y1 - 1999
N2 - The RCK gene is a target of the t(11;14)(q23;q32) chromosomal translocation observed in human B-cell lymphoma, and the overexpression of its protein (rck/p54) by the translocation was shown to cause malignant transformation. The rck/p54 protein belongs to the DEAD box protein/RNA helicase family, which has a variety of functions such as translation initiation, pre-mRNA splicing and ribosome assembly. The expression of rck p54 in colorectal adenocarcinoma cells was examined by immunohistochemistry and Western blot analysis. The rck/p54 protein was found to be overexpressed in tumour tissues resected from 13 (50%) out of 26 cases of colorectal adenocarcinomas and two out of two (100%) cases of colonic severe dysplastic adenomas. In view of activities of rck/p54 determined in other tissue types, we suggest that rck/p54 may contribute to the cell proliferation and carcinogenesis at the translational level in the development of colorectal tumours.
AB - The RCK gene is a target of the t(11;14)(q23;q32) chromosomal translocation observed in human B-cell lymphoma, and the overexpression of its protein (rck/p54) by the translocation was shown to cause malignant transformation. The rck/p54 protein belongs to the DEAD box protein/RNA helicase family, which has a variety of functions such as translation initiation, pre-mRNA splicing and ribosome assembly. The expression of rck p54 in colorectal adenocarcinoma cells was examined by immunohistochemistry and Western blot analysis. The rck/p54 protein was found to be overexpressed in tumour tissues resected from 13 (50%) out of 26 cases of colorectal adenocarcinomas and two out of two (100%) cases of colonic severe dysplastic adenomas. In view of activities of rck/p54 determined in other tissue types, we suggest that rck/p54 may contribute to the cell proliferation and carcinogenesis at the translational level in the development of colorectal tumours.
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U2 - 10.1038/sj.bjc.6690441
DO - 10.1038/sj.bjc.6690441
M3 - Article
C2 - 10360675
AN - SCOPUS:0032897657
SN - 0007-0920
VL - 80
SP - 914
EP - 917
JO - British Journal of Cancer
JF - British Journal of Cancer
IS - 5-6
ER -
