Overexpression of rck/p54, a DEAD box protein, in human colorectal tumours

Y. Nakagawa, H. Morikawa, I. Hirata, M. Shiozaki, A. Matsumoto, K. Maemura, T. Nishikawa, M. Niki, N. Tanigawa, M. Ikegami, K. Katsu, Y. Akao

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Abstract

The RCK gene is a target of the t(11;14)(q23;q32) chromosomal translocation observed in human B-cell lymphoma, and the overexpression of its protein (rck/p54) by the translocation was shown to cause malignant transformation. The rck/p54 protein belongs to the DEAD box protein/RNA helicase family, which has a variety of functions such as translation initiation, pre-mRNA splicing and ribosome assembly. The expression of rck p54 in colorectal adenocarcinoma cells was examined by immunohistochemistry and Western blot analysis. The rck/p54 protein was found to be overexpressed in tumour tissues resected from 13 (50%) out of 26 cases of colorectal adenocarcinomas and two out of two (100%) cases of colonic severe dysplastic adenomas. In view of activities of rck/p54 determined in other tissue types, we suggest that rck/p54 may contribute to the cell proliferation and carcinogenesis at the translational level in the development of colorectal tumours.

Original languageEnglish
Pages (from-to)914-917
Number of pages4
JournalBritish Journal of Cancer
Volume80
Issue number5-6
DOIs
Publication statusPublished - 17-05-1999
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Nakagawa, Y., Morikawa, H., Hirata, I., Shiozaki, M., Matsumoto, A., Maemura, K., Nishikawa, T., Niki, M., Tanigawa, N., Ikegami, M., Katsu, K., & Akao, Y. (1999). Overexpression of rck/p54, a DEAD box protein, in human colorectal tumours. British Journal of Cancer, 80(5-6), 914-917. https://doi.org/10.1038/sj.bjc.6690441