TY - JOUR
T1 - Overview of the BioBank Japan Project
T2 - Study design and profile
AU - BioBank Japan Cooperative Hospital Group
AU - Nagai, Akiko
AU - Hirata, Makoto
AU - Kamatani, Yoichiro
AU - Muto, Kaori
AU - Matsuda, Koichi
AU - Kiyohara, Yutaka
AU - Ninomiya, Toshiharu
AU - Tamakoshi, Akiko
AU - Yamagata, Zentaro
AU - Mushiroda, Taisei
AU - Murakami, Yoshinori
AU - Yuji, Koichiro
AU - Furukawa, Yoichi
AU - Zembutsu, Hitoshi
AU - Tanaka, Toshihiro
AU - Ohnishi, Yozo
AU - Nakamura, Yusuke
AU - Kubo, Michiaki
AU - Shiono, Masaki
AU - Misumi, Kazuo
AU - Kaieda, Reiji
AU - Harada, Hiromasa
AU - Minami, Shiro
AU - Emi, Mitsuru
AU - Emoto, Naoya
AU - Daida, Hiroyuki
AU - Miyauchi, Katsumi
AU - Murakami, Akira
AU - Asai, Satoshi
AU - Moriyama, Mitsuhiko
AU - Takahashi, Yasuo
AU - Fujioka, Tomoaki
AU - Obara, Wataru
AU - Mori, Seijiro
AU - Ito, Hideki
AU - Nagayama, Satoshi
AU - Miki, Yoshio
AU - Masumoto, Akihide
AU - Yamada, Akira
AU - Nishizawa, Yasuko
AU - Kodama, Ken
AU - Kutsumi, Hiromu
AU - Sugimoto, Yoshihisa
AU - Koretsune, Yukihiro
AU - Kusuoka, Hideo
AU - Yanai, Hideki
N1 - Publisher Copyright:
© 2017 The Authors.
PY - 2017
Y1 - 2017
N2 - Background: The BioBank Japan (BBJ) Project was launched in 2003 with the aim of providing evidence for the implementation of personalized medicine by constructing a large, patient-based biobank (BBJ). This report describes the study design and profile of BBJ participants who were registered during the first 5-year period of the project. Methods: The BBJ is a registry of patients diagnosed with any of 47 target common diseases. Patients were enrolled at 12 cooperative medical institutes all over Japan from June 2003 to March 2008. Clinical information was collected annually via interviews and medical record reviews until 2013. We collected DNA from all participants at baseline and collected annual serum samples until 2013. In addition, we followed patients who reported a history of 32 of the 47 target diseases to collect survival data, including cause of death. Results: During the 5-year period, 200,000 participants were registered in the study. The total number of cases was 291,274 at baseline. Baseline data for 199,982 participants (53.1% male) were available for analysis. The average age at entry was 62.7 years for men and 61.5 years for women. Follow-up surveys were performed for participants with any of 32 diseases, and survival time data for 141,612 participants were available for analysis.
AB - Background: The BioBank Japan (BBJ) Project was launched in 2003 with the aim of providing evidence for the implementation of personalized medicine by constructing a large, patient-based biobank (BBJ). This report describes the study design and profile of BBJ participants who were registered during the first 5-year period of the project. Methods: The BBJ is a registry of patients diagnosed with any of 47 target common diseases. Patients were enrolled at 12 cooperative medical institutes all over Japan from June 2003 to March 2008. Clinical information was collected annually via interviews and medical record reviews until 2013. We collected DNA from all participants at baseline and collected annual serum samples until 2013. In addition, we followed patients who reported a history of 32 of the 47 target diseases to collect survival data, including cause of death. Results: During the 5-year period, 200,000 participants were registered in the study. The total number of cases was 291,274 at baseline. Baseline data for 199,982 participants (53.1% male) were available for analysis. The average age at entry was 62.7 years for men and 61.5 years for women. Follow-up surveys were performed for participants with any of 32 diseases, and survival time data for 141,612 participants were available for analysis.
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U2 - 10.1016/j.je.2016.12.005
DO - 10.1016/j.je.2016.12.005
M3 - Article
C2 - 28189464
AN - SCOPUS:85016438418
SN - 0917-5040
VL - 27
SP - S2-S8
JO - Journal of epidemiology
JF - Journal of epidemiology
IS - 3
ER -