Overview of the epidemiology of pancreatic cancer focusing on the JACC Study

Dongmei Qiu, Michiko Kurosawa, Yingsong Lin, Yutaka Inaba, Tsuyoshi Matsuba, Shogo Kikuchi, Kiyoko Yagyu, Yutaka Motohashi, Akiko Tamakoshi, Mitsuru Mori, Ichiro Tsuji, Yosikazu Nakamura, Hiroyasu Iso, Haruo Mikami, Yoshiharu Hoshiyama, Hiroshi Suzuki, Hiroyuki Shimizu, Hideaki Toyoshima, Shinkan Tokudome, Yoshinori ItoShuji Hashimoto, Akio Koizumi, Takashi Kawamura, Yoshiyuki Watanabe, Tsuneharu Miki, Chigusa Date, Kiyomi Sakata, Takayuki Nose, Norihiko Hayakawa, Takesumi Yoshimura, Akira Shibata, Naoyuki Okamoto, Hideo Shio, Yoshiyuki Ohno, Tomoyuki Kitagawa, Toshio Kuroki, Kazuo Tajima

Research output: Contribution to journalReview article

55 Citations (Scopus)

Abstract

Background: The objective of this article was to overview the epidemiology of pancreatic cancer. We summarize the results of the Japan Collaborative Cohort Study (JACC Study) and some previous Studies. Methods: References were mainly in a Medline search through Pub Med database. In addition, 3 papers about the JACC Study were quoted. Results: In the JACC Study, the standardized mortality ratio of pancreatic cancer was 0.97 in females and 0.84 in males. Diabetes mellitus (DM) has increased the risk for pancreatic cancer in many studies. In the JACC Study, DM had a risk for pancreatic cancer in males (hazard ratio = 2.12). Cigarette smoking has been associated with pancreatic cancer in many studies. In the JACC Study, the hazard ratio for current smokers was 1.6 in males, and 1.7 in females. The ratio was 3.3 who smoked 40+ cigarettes/day in males. In the JACC Study, alcohol intake was not associated with pancreatic cancer. These results are consistent with the other studies. Coffee consumption has not been associated with pancreatic cancer in many studies. In the JACC Study, the hazard ratio significantly increased to 3.19 among men who consumed 4+ cups of coffee per day. The relationships between diet /nutrition and pancreatic cancer are not clear in many studies. Conclusion: The relation between smoking and pancreatic cancer is most consistently described. A further analysis of the relationships between family history, hormonal factors in females, dietary and nutritional factors, obesity, physical activity and pancreatic cancer is necessary.

Original languageEnglish
Pages (from-to)S157-S167
JournalJournal of epidemiology
Volume15
Issue numberSUPPL. 2
DOIs
Publication statusPublished - 2005

All Science Journal Classification (ASJC) codes

  • Epidemiology

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    Qiu, D., Kurosawa, M., Lin, Y., Inaba, Y., Matsuba, T., Kikuchi, S., Yagyu, K., Motohashi, Y., Tamakoshi, A., Mori, M., Tsuji, I., Nakamura, Y., Iso, H., Mikami, H., Hoshiyama, Y., Suzuki, H., Shimizu, H., Toyoshima, H., Tokudome, S., ... Tajima, K. (2005). Overview of the epidemiology of pancreatic cancer focusing on the JACC Study. Journal of epidemiology, 15(SUPPL. 2), S157-S167. https://doi.org/10.2188/jea.15.S157