Oxidative stress after living related liver transplantation subsides with time in pediatric patients

Mohamed Hamed Hussein, Takashi Hashimoto, Ghada Abdel Hamid Daoud, Hiroki Kakita, Shin Kato, Tatenobu Goto, Masahito Hibi, Takazumi Kato, Naotake Okumura, Hirokazu Tomishige, Fujio Hara, Tetsuya Ito, Sumio Fukuda, Ineko Kato, Tatsuya Suzuki, Satoshi Suzuki, Hajime Togari

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Background: Oxidative stress has been suspected to influence graft survival and prognosis in pediatric recipients of living related liver transplantation (LRLT). Purpose: We determined the oxidative status of pediatric LRLT recipients during their regular outpatient follow-up visits, and looked for a relationship between oxidative status and post-liver transplantation (post-LTx) duration. Patients: The study included 43 patients (20 males and 23 females) between the ages of 1.6 and 25.1 years (median 10.7 years) who had undergone LRLT from 5 months to 17.5 years (median 7 years) prior to the study, between the ages of 1.2 and 14.4 years (median 3.5 years). Methods: Serum glutamic pyruvic transaminase (GPT), glutamic oxaloacetic transaminase (GOT), gamma-glutamyl transpeptidase (γ-GTP), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), direct bilirubin and choline-esterase were measured as part of the patients' regular follow-up visits. Serum total hydroperoxide (TH) and biological antioxidative potential (BAP) were measured using the free radical analytic system which requires 20 μl of serum and 10 min of processing time for each sample. Oxidative stress index (OSI) was calculated as the ratio of TH to BAP. Results: Serum OSI correlated positively with serum levels of GOT, GPT, LDH, ALP, γ-GTP and direct bilirubin. Serum OSI, TH, LDH, ALP and GOT correlated negatively with post-LTx duration. Serum BAP correlated positively with post-LTx duration. Serum TH correlated positively with serum GOT and γ-GTP, but negatively with serum BAP. Conclusions: (1) The OSI, which can be calculated based on data acquired through a simple outpatient procedure, can serve as an index of our patients' laboratory results and oxidative status. (2) The LRLT recipients in our study were at risk for oxidative stress early in the post-operative period, but this risk subsided with time.

Original languageEnglish
Pages (from-to)17-22
Number of pages6
JournalPediatric Surgery International
Volume27
Issue number1
DOIs
Publication statusPublished - 01-2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Surgery

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