TY - JOUR
T1 - Oxygen-enhanced MRI, thin-section MDCT, and perfusion SPECT/CT
T2 - Comparison of clinical implications to patient care for lung volume reduction surgery
AU - Ohno, Yoshiharu
AU - Nishio, Mizuho
AU - Koyama, Hisanobu
AU - Yoshikawa, Takeshi
AU - Matsumoto, Sumiaki
AU - Takenaka, Daisuke
AU - Sugimura, Kazuro
PY - 2012/10
Y1 - 2012/10
N2 - OBJECTIVE. The purpose of our study was to prospectively and directly compare capability of O2-enhanced MRI, MDCT, and perfusion SPECT/CT to clinical outcome measurements in candidates for lung volume reduction surgery (LVRS). SUBJECTS AND METHODS. Twenty-five consecutive candidates for LVRS (20 men and five women; age range, 45-76 years) underwent MDCT, O 2-enhanced MRI, and perfusion SPECT/CT before and after LVRS. Clinical outcomes for each candidate were evaluated in terms of differences between pre- and postoperative percentage forced expiratory volume in 1 second (%FEV1), Pao2, and 6-minute walking distance. Quantitatively assessed upper/lower lung ratios on O2-enhanced MRI, MDCT, and SPECT/CT were calculated from regional relative enhancement ratios, functional lung volumes, and radioisotope uptakes between upper and lower lungs. Qualitatively assessed upper/lower lung ratios on O2-enhanced MRI, MDCT, and SPECT/CT were estimated using visual scoring systems. To evaluate the correlation for individual upper/lower lung ratios and clinical outcomes, all upper/lower lung ratios were correlated with clinical outcomes. Improvements in mean relative enhancement ratio were directly correlated with clinical outcomes to assess the capability of O2-enhanced MRI to assess therapeutic effect. RESULTS. All quantitatively (-0.63 ≤ r ≤ -0.47, p < 0.05) and qualitatively (0.41 ≤ r ≤ 0.57, p < 0.05) assessed upper/lower lung ratios showed moderate and statistically significant correlation with clinical outcomes, and improvement in mean relative enhancement ratio showed moderate or good correlation, both statistically significant (-0.44 ≤ r ≤ 0.71, p < 0.05). CONCLUSION. O2-enhanced MRI shows potential for more accurate evaluation of postoperative clinical outcome for LVRS candidates than SPECT/CT and can be considered at least as reliable as MDCT.
AB - OBJECTIVE. The purpose of our study was to prospectively and directly compare capability of O2-enhanced MRI, MDCT, and perfusion SPECT/CT to clinical outcome measurements in candidates for lung volume reduction surgery (LVRS). SUBJECTS AND METHODS. Twenty-five consecutive candidates for LVRS (20 men and five women; age range, 45-76 years) underwent MDCT, O 2-enhanced MRI, and perfusion SPECT/CT before and after LVRS. Clinical outcomes for each candidate were evaluated in terms of differences between pre- and postoperative percentage forced expiratory volume in 1 second (%FEV1), Pao2, and 6-minute walking distance. Quantitatively assessed upper/lower lung ratios on O2-enhanced MRI, MDCT, and SPECT/CT were calculated from regional relative enhancement ratios, functional lung volumes, and radioisotope uptakes between upper and lower lungs. Qualitatively assessed upper/lower lung ratios on O2-enhanced MRI, MDCT, and SPECT/CT were estimated using visual scoring systems. To evaluate the correlation for individual upper/lower lung ratios and clinical outcomes, all upper/lower lung ratios were correlated with clinical outcomes. Improvements in mean relative enhancement ratio were directly correlated with clinical outcomes to assess the capability of O2-enhanced MRI to assess therapeutic effect. RESULTS. All quantitatively (-0.63 ≤ r ≤ -0.47, p < 0.05) and qualitatively (0.41 ≤ r ≤ 0.57, p < 0.05) assessed upper/lower lung ratios showed moderate and statistically significant correlation with clinical outcomes, and improvement in mean relative enhancement ratio showed moderate or good correlation, both statistically significant (-0.44 ≤ r ≤ 0.71, p < 0.05). CONCLUSION. O2-enhanced MRI shows potential for more accurate evaluation of postoperative clinical outcome for LVRS candidates than SPECT/CT and can be considered at least as reliable as MDCT.
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U2 - 10.2214/AJR.11.8250
DO - 10.2214/AJR.11.8250
M3 - Article
C2 - 22997370
AN - SCOPUS:84866869134
SN - 0361-803X
VL - 199
SP - 794
EP - 802
JO - American Journal of Roentgenology
JF - American Journal of Roentgenology
IS - 4
ER -