TY - JOUR
T1 - Oxygen management in mechanically ventilated patients
T2 - A multicenter prospective observational study
AU - ABOVE investigators
AU - Egi, Moritoki
AU - Kataoka, Jun
AU - Ito, Takashi
AU - Nishida, Osamu
AU - Yasuda, Hideto
AU - Okamaoto, Hiroshi
AU - Shimoyama, Akira
AU - Izawa, Masayo
AU - Matsumoto, Shinsaku
AU - Furushima, Nana
AU - Yamashita, Shigeki
AU - Takada, Koji
AU - Ohtsuka, Masahide
AU - Fujisaki, Noritomo
AU - Shime, Nobuaki
AU - Inagaki, Nobuhiro
AU - Taira, Yasuhiko
AU - Yatabe, Tomoaki
AU - Nitta, Kenichi
AU - Yokoyama, Takeshi
AU - Kushimoto, Shigeki
AU - Tokunaga, Kentaro
AU - Doi, Matsuyuki
AU - Masuda, Takahiro
AU - Miki, Yasuo
AU - Matsuda, Kenichi
AU - Asaga, Takehiko
AU - Hazama, Keita
AU - Matsuyama, Hiroki
AU - Nishimura, Masaji
AU - Mizobuchi, Satoshi
N1 - Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Purpose: To observe arterial oxygen in relation to fraction of inspired oxygen (FIO2) during mechanical ventilation (MV). Materials and methods: In this multicenter prospective observational study, we included adult patients required MV for >48 h during the period from March to May 2015. We obtained FIO2, PaO2 and SaO2 from commencement of MV until the 7th day of MV in the ICU. Results: We included 454 patients from 28 ICUs in this study. The median APACHE II score was 22. Median values of FIO2, PaO2 and SaO2 were 0.40, 96 mm Hg and 98%. After day two, patients spent most of their time with a FIO2 between 0.3 and 0.49 with median PaO2 of approximately 90 mm Hg and SaO2 of 97%. PaO2 was ≥100 mm Hg during 47.2% of the study period and was ≥130 mm Hg during 18.4% of the study period. FIO2 was more likely decreased when PaO2 was ≥130 mm Hg or SaO2 was ≥99% with a FIO2 of 0.5 or greater. When FIO2 was <0.5, however, FIO2 was less likely decreased regardless of the value of PaO2 and SaO2. Conclusions: In our multicenter prospective study, we found that hyperoxemia was common and that hyperoxemia was not corrected.
AB - Purpose: To observe arterial oxygen in relation to fraction of inspired oxygen (FIO2) during mechanical ventilation (MV). Materials and methods: In this multicenter prospective observational study, we included adult patients required MV for >48 h during the period from March to May 2015. We obtained FIO2, PaO2 and SaO2 from commencement of MV until the 7th day of MV in the ICU. Results: We included 454 patients from 28 ICUs in this study. The median APACHE II score was 22. Median values of FIO2, PaO2 and SaO2 were 0.40, 96 mm Hg and 98%. After day two, patients spent most of their time with a FIO2 between 0.3 and 0.49 with median PaO2 of approximately 90 mm Hg and SaO2 of 97%. PaO2 was ≥100 mm Hg during 47.2% of the study period and was ≥130 mm Hg during 18.4% of the study period. FIO2 was more likely decreased when PaO2 was ≥130 mm Hg or SaO2 was ≥99% with a FIO2 of 0.5 or greater. When FIO2 was <0.5, however, FIO2 was less likely decreased regardless of the value of PaO2 and SaO2. Conclusions: In our multicenter prospective study, we found that hyperoxemia was common and that hyperoxemia was not corrected.
KW - Arterial oxygen
KW - Fraction of inspired oxygen
KW - Hyperoxemia
KW - Mechanical ventilation
KW - Multicenter
KW - Prospective
UR - http://www.scopus.com/inward/record.url?scp=85044599521&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85044599521&partnerID=8YFLogxK
U2 - 10.1016/j.jcrc.2018.03.024
DO - 10.1016/j.jcrc.2018.03.024
M3 - Article
C2 - 29605719
AN - SCOPUS:85044599521
SN - 0883-9441
VL - 46
SP - 1
EP - 5
JO - Journal of Critical Care
JF - Journal of Critical Care
ER -