TY - JOUR
T1 - PADI4 polymorphism predisposes male smokers to rheumatoid arthritis
AU - Kochi, Yuta
AU - Thabet, Mohamed M.
AU - Suzuki, Akari
AU - Okada, Yukinori
AU - Daha, Nina A.
AU - Toes, René E.M.
AU - Huizinga, Tom W.J.
AU - Myouzen, Keiko
AU - Kubo, Michiaki
AU - Yamada, Ryo
AU - Nakamura, Yusuke
AU - Yamamoto, Kazuhiko
PY - 2011/3
Y1 - 2011/3
N2 - Objective: To elucidate the differential role of peptidyl arginine deiminase 4 (PADI4) polymorphism in rheumatoid arthritis (RA) between Asian and European populations, possible gene-environmental interactions among the PADI4 polymorphism, sex and smoking status were analysed. Methods: Three independent sets of case-control samples were genotyped for single-nucleotide polymorphisms in PADI4;Japanese samples (first set, 1019 RA patients, 907 controls; second set, 999 RA patients, 1128 controls) using TaqMan assays and Dutch samples (635 RA patients, 391 controls) using Sequenom MassARRAY platform. The association of PADI4 with RA susceptibility was evaluated by smoking status and sex in contingency tables and logistic regression models. Results: In the first set of Japanese samples, PADI4 polymorphism (rs1748033) showed a greater risk in men (ORallele 1.39; 95% CI 1.10 to 1.76; ptrend =0.0054) than in women and in ever-smokers (ORallele 1.25; 95% CI 1.02 to 1.53; ptrend =0.032) than in never-smokers. Moreover, the highest risk was seen in male ever-smokers (ORallele 1.46; 95% CI 1.12 to 1.90; p trend =0.0047). Similar trends were observed in the second set of Japanese samples as well as in Dutch samples. Conclusion: PADI4 polymorphism highly predisposes male smokers to RA, and the genetic heterogeneity observed between Asian and European populations may be partly explained by differences in smoking prevalence among men.
AB - Objective: To elucidate the differential role of peptidyl arginine deiminase 4 (PADI4) polymorphism in rheumatoid arthritis (RA) between Asian and European populations, possible gene-environmental interactions among the PADI4 polymorphism, sex and smoking status were analysed. Methods: Three independent sets of case-control samples were genotyped for single-nucleotide polymorphisms in PADI4;Japanese samples (first set, 1019 RA patients, 907 controls; second set, 999 RA patients, 1128 controls) using TaqMan assays and Dutch samples (635 RA patients, 391 controls) using Sequenom MassARRAY platform. The association of PADI4 with RA susceptibility was evaluated by smoking status and sex in contingency tables and logistic regression models. Results: In the first set of Japanese samples, PADI4 polymorphism (rs1748033) showed a greater risk in men (ORallele 1.39; 95% CI 1.10 to 1.76; ptrend =0.0054) than in women and in ever-smokers (ORallele 1.25; 95% CI 1.02 to 1.53; ptrend =0.032) than in never-smokers. Moreover, the highest risk was seen in male ever-smokers (ORallele 1.46; 95% CI 1.12 to 1.90; p trend =0.0047). Similar trends were observed in the second set of Japanese samples as well as in Dutch samples. Conclusion: PADI4 polymorphism highly predisposes male smokers to RA, and the genetic heterogeneity observed between Asian and European populations may be partly explained by differences in smoking prevalence among men.
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U2 - 10.1136/ard.2010.130526
DO - 10.1136/ard.2010.130526
M3 - Article
C2 - 21062850
AN - SCOPUS:79951515173
SN - 0003-4967
VL - 70
SP - 512
EP - 515
JO - Annals of the Rheumatic Diseases
JF - Annals of the Rheumatic Diseases
IS - 3
ER -