PADI4 polymorphism predisposes male smokers to rheumatoid arthritis

Yuta Kochi, Mohamed M. Thabet, Akari Suzuki, Yukinori Okada, Nina A. Daha, René E.M. Toes, Tom W.J. Huizinga, Keiko Myouzen, Michiaki Kubo, Ryo Yamada, Yusuke Nakamura, Kazuhiko Yamamoto

Research output: Contribution to journalArticle

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Abstract

Objective: To elucidate the differential role of peptidyl arginine deiminase 4 (PADI4) polymorphism in rheumatoid arthritis (RA) between Asian and European populations, possible gene-environmental interactions among the PADI4 polymorphism, sex and smoking status were analysed. Methods: Three independent sets of case-control samples were genotyped for single-nucleotide polymorphisms in PADI4;Japanese samples (first set, 1019 RA patients, 907 controls; second set, 999 RA patients, 1128 controls) using TaqMan assays and Dutch samples (635 RA patients, 391 controls) using Sequenom MassARRAY platform. The association of PADI4 with RA susceptibility was evaluated by smoking status and sex in contingency tables and logistic regression models. Results: In the first set of Japanese samples, PADI4 polymorphism (rs1748033) showed a greater risk in men (ORallele 1.39; 95% CI 1.10 to 1.76; ptrend =0.0054) than in women and in ever-smokers (ORallele 1.25; 95% CI 1.02 to 1.53; ptrend =0.032) than in never-smokers. Moreover, the highest risk was seen in male ever-smokers (ORallele 1.46; 95% CI 1.12 to 1.90; p trend =0.0047). Similar trends were observed in the second set of Japanese samples as well as in Dutch samples. Conclusion: PADI4 polymorphism highly predisposes male smokers to RA, and the genetic heterogeneity observed between Asian and European populations may be partly explained by differences in smoking prevalence among men.

Original languageEnglish
Pages (from-to)512-515
Number of pages4
JournalAnnals of the Rheumatic Diseases
Volume70
Issue number3
DOIs
Publication statusPublished - 01-03-2011
Externally publishedYes

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Polymorphism
Rheumatoid Arthritis
Smoking
Logistic Models
Genetic Heterogeneity
Population
Single Nucleotide Polymorphism
arginine deiminase
Logistics
Assays
Nucleotides
Genes
Association reactions

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Kochi, Y., Thabet, M. M., Suzuki, A., Okada, Y., Daha, N. A., Toes, R. E. M., ... Yamamoto, K. (2011). PADI4 polymorphism predisposes male smokers to rheumatoid arthritis. Annals of the Rheumatic Diseases, 70(3), 512-515. https://doi.org/10.1136/ard.2010.130526
Kochi, Yuta ; Thabet, Mohamed M. ; Suzuki, Akari ; Okada, Yukinori ; Daha, Nina A. ; Toes, René E.M. ; Huizinga, Tom W.J. ; Myouzen, Keiko ; Kubo, Michiaki ; Yamada, Ryo ; Nakamura, Yusuke ; Yamamoto, Kazuhiko. / PADI4 polymorphism predisposes male smokers to rheumatoid arthritis. In: Annals of the Rheumatic Diseases. 2011 ; Vol. 70, No. 3. pp. 512-515.
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abstract = "Objective: To elucidate the differential role of peptidyl arginine deiminase 4 (PADI4) polymorphism in rheumatoid arthritis (RA) between Asian and European populations, possible gene-environmental interactions among the PADI4 polymorphism, sex and smoking status were analysed. Methods: Three independent sets of case-control samples were genotyped for single-nucleotide polymorphisms in PADI4;Japanese samples (first set, 1019 RA patients, 907 controls; second set, 999 RA patients, 1128 controls) using TaqMan assays and Dutch samples (635 RA patients, 391 controls) using Sequenom MassARRAY platform. The association of PADI4 with RA susceptibility was evaluated by smoking status and sex in contingency tables and logistic regression models. Results: In the first set of Japanese samples, PADI4 polymorphism (rs1748033) showed a greater risk in men (ORallele 1.39; 95{\%} CI 1.10 to 1.76; ptrend =0.0054) than in women and in ever-smokers (ORallele 1.25; 95{\%} CI 1.02 to 1.53; ptrend =0.032) than in never-smokers. Moreover, the highest risk was seen in male ever-smokers (ORallele 1.46; 95{\%} CI 1.12 to 1.90; p trend =0.0047). Similar trends were observed in the second set of Japanese samples as well as in Dutch samples. Conclusion: PADI4 polymorphism highly predisposes male smokers to RA, and the genetic heterogeneity observed between Asian and European populations may be partly explained by differences in smoking prevalence among men.",
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Kochi, Y, Thabet, MM, Suzuki, A, Okada, Y, Daha, NA, Toes, REM, Huizinga, TWJ, Myouzen, K, Kubo, M, Yamada, R, Nakamura, Y & Yamamoto, K 2011, 'PADI4 polymorphism predisposes male smokers to rheumatoid arthritis', Annals of the Rheumatic Diseases, vol. 70, no. 3, pp. 512-515. https://doi.org/10.1136/ard.2010.130526

PADI4 polymorphism predisposes male smokers to rheumatoid arthritis. / Kochi, Yuta; Thabet, Mohamed M.; Suzuki, Akari; Okada, Yukinori; Daha, Nina A.; Toes, René E.M.; Huizinga, Tom W.J.; Myouzen, Keiko; Kubo, Michiaki; Yamada, Ryo; Nakamura, Yusuke; Yamamoto, Kazuhiko.

In: Annals of the Rheumatic Diseases, Vol. 70, No. 3, 01.03.2011, p. 512-515.

Research output: Contribution to journalArticle

TY - JOUR

T1 - PADI4 polymorphism predisposes male smokers to rheumatoid arthritis

AU - Kochi, Yuta

AU - Thabet, Mohamed M.

AU - Suzuki, Akari

AU - Okada, Yukinori

AU - Daha, Nina A.

AU - Toes, René E.M.

AU - Huizinga, Tom W.J.

AU - Myouzen, Keiko

AU - Kubo, Michiaki

AU - Yamada, Ryo

AU - Nakamura, Yusuke

AU - Yamamoto, Kazuhiko

PY - 2011/3/1

Y1 - 2011/3/1

N2 - Objective: To elucidate the differential role of peptidyl arginine deiminase 4 (PADI4) polymorphism in rheumatoid arthritis (RA) between Asian and European populations, possible gene-environmental interactions among the PADI4 polymorphism, sex and smoking status were analysed. Methods: Three independent sets of case-control samples were genotyped for single-nucleotide polymorphisms in PADI4;Japanese samples (first set, 1019 RA patients, 907 controls; second set, 999 RA patients, 1128 controls) using TaqMan assays and Dutch samples (635 RA patients, 391 controls) using Sequenom MassARRAY platform. The association of PADI4 with RA susceptibility was evaluated by smoking status and sex in contingency tables and logistic regression models. Results: In the first set of Japanese samples, PADI4 polymorphism (rs1748033) showed a greater risk in men (ORallele 1.39; 95% CI 1.10 to 1.76; ptrend =0.0054) than in women and in ever-smokers (ORallele 1.25; 95% CI 1.02 to 1.53; ptrend =0.032) than in never-smokers. Moreover, the highest risk was seen in male ever-smokers (ORallele 1.46; 95% CI 1.12 to 1.90; p trend =0.0047). Similar trends were observed in the second set of Japanese samples as well as in Dutch samples. Conclusion: PADI4 polymorphism highly predisposes male smokers to RA, and the genetic heterogeneity observed between Asian and European populations may be partly explained by differences in smoking prevalence among men.

AB - Objective: To elucidate the differential role of peptidyl arginine deiminase 4 (PADI4) polymorphism in rheumatoid arthritis (RA) between Asian and European populations, possible gene-environmental interactions among the PADI4 polymorphism, sex and smoking status were analysed. Methods: Three independent sets of case-control samples were genotyped for single-nucleotide polymorphisms in PADI4;Japanese samples (first set, 1019 RA patients, 907 controls; second set, 999 RA patients, 1128 controls) using TaqMan assays and Dutch samples (635 RA patients, 391 controls) using Sequenom MassARRAY platform. The association of PADI4 with RA susceptibility was evaluated by smoking status and sex in contingency tables and logistic regression models. Results: In the first set of Japanese samples, PADI4 polymorphism (rs1748033) showed a greater risk in men (ORallele 1.39; 95% CI 1.10 to 1.76; ptrend =0.0054) than in women and in ever-smokers (ORallele 1.25; 95% CI 1.02 to 1.53; ptrend =0.032) than in never-smokers. Moreover, the highest risk was seen in male ever-smokers (ORallele 1.46; 95% CI 1.12 to 1.90; p trend =0.0047). Similar trends were observed in the second set of Japanese samples as well as in Dutch samples. Conclusion: PADI4 polymorphism highly predisposes male smokers to RA, and the genetic heterogeneity observed between Asian and European populations may be partly explained by differences in smoking prevalence among men.

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Kochi Y, Thabet MM, Suzuki A, Okada Y, Daha NA, Toes REM et al. PADI4 polymorphism predisposes male smokers to rheumatoid arthritis. Annals of the Rheumatic Diseases. 2011 Mar 1;70(3):512-515. https://doi.org/10.1136/ard.2010.130526