Pain relief of oral ulcer by dibucaine-film

Keiko Yamamura, Toshihisa Yotsuyanagi, Tomomitsu Okamoto, Toshitaka Nabeshima

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


A water-soluble three-layered oral mucosa-adhesive film made from hydroxypropyl cellulose containing dibucaine (0.25 mg of drug/cm2) was designed for alleviation of severe pain due to oral ulcers, caused by chemotherapy and/or radiotherapy. We report two patients with constant severe pain ulcers treated with the dibucaine film. Patients were asked to record the time that pain was relieved while chewing following first application of the film. Pain relief lasted for 2-5 h after application of the dibucaine film.

Original languageEnglish
Pages (from-to)625-626
Number of pages2
Issue number3
Publication statusPublished - 01-12-1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Anesthesiology and Pain Medicine


Dive into the research topics of 'Pain relief of oral ulcer by dibucaine-film'. Together they form a unique fingerprint.

Cite this