Palindrome-mediated chromosomal translocations in humans

Hiroki Kurahashi, Hidehito Inagaki, Tamae Oe, Hiroshi Kogo, Takema Kato, Beverly S. Emanuel

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Recently, it has emerged that palindrome-mediated genomic instability contributes to a diverse group of genomic rearrangements including translocations, deletions, and amplifications. One of the best studied examples is the recurrent t(11;22) constitutional translocation in humans that has been well documented to be mediated by palindromic AT-rich repeats (PATRRs) on chromosomes 11q23 and 22q11. De novo examples of the translocation are detected at a high frequency in sperm samples from normal healthy males, but not in lymphoblasts or fibroblasts. Cloned breakpoint sequences preferentially form a cruciform configuration in vitro. Analysis of the junction fragments implicates frequent double-strand-breaks (DSBs) at the center of both palindromic regions, followed by repair through the non-homologous end joining (NHEJ) pathway. We propose that the PATRR adopts a cruciform structure in male meiotic cells, creating genomic instability that leads to the recurrent translocation.

Original languageEnglish
Pages (from-to)1136-1145
Number of pages10
JournalDNA Repair
Volume5
Issue number9-10
DOIs
Publication statusPublished - 08-09-2006

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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