Pancreatic endocrine neoplasm can mimic serous cystadenoma

Hiroshi Imaoka, Kenji Yamao, Ahmed A.S. Salem, Akira Sawaki, Kuniyuki Takahashi, Nobumasa Mizuno, Hiroki Kawai, Masahiro Tajika, Toshifumi Isaka, Yasuyuki Okamoto, Yasuhiro Shimizu, Akio Yanagisawa

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11 Citations (Scopus)


A 57-yr-old female patient was referred to our hospital with a cystic lesion of the head of the pancreas that had been noted on abdominal computed tomography (CT). Endoscopic ultrasonography (EUS) showed a 3.0 cm rounded mass in the head of the pancreas. EUS images showed that the tumor had a solid component consisting of multiple microcysts separated by septae and a cystic component consisting of a macrocystic lesion. Thus, the tumor was suspected of being a serous cystadenoma (SCA). However, the histopathological diagnosis based on endoscopic ultrasound- guided fine-needle-aspiration biopsy (EUS-FNAB) was that of a pancreatic endocrine neoplasm (PEN). Surgical resection was performed. Despite having very similar macroscopic findings to SCA, microscopic examination revealed that the patient's tumor was definitely a PEN. This case suggests that it is very difficult to distinguish PENs from SCAs based solely on imaging methods. EUS-FNAB is essential for determining the appropriate therapeutic strategy, as it provides the histopathological diagnosis.

Original languageEnglish
Pages (from-to)217-220
Number of pages4
JournalInternational Journal of Gastrointestinal Cancer
Issue number3
Publication statusPublished - 06-2005

All Science Journal Classification (ASJC) codes

  • Oncology
  • Endocrinology
  • Gastroenterology


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