PAP 9704, a Korean herbal medicine attenuates methamphetamine-induced hyperlocomotion via adenosine A2A receptor stimulation in mice

Yong Soo Kwon, Toshitaka Nabeshima, Eun Joo Shin, Wanjoo Chun, Jin Hyeong Jhoo, Wang Kee Jhoo, Myung Bok Wie, Choon Gon Jang, Heesun Chung, Young Eun Sung, Hyoung Chun Kim

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Abstract

The effect of PAP 9704, a traditional prescription in Korea consisting of Polygala tenuifolia, Acorus gramineus, and Poria cocos at a ratio of 1:1:1 (dry weight), on methamphetamine (MA)-induced hyperlocomotion was examined in mice. The increased locomotor activity induced by MA (1 mg/kg/d, i.p.×7) was significantly attenuated by co-administration with PAP 9704 (100 or 200 mg/kg/d, p.o.×7) in a dose dependent manner. Consistently, it was found that the hyperlocomotor activity occurred in parallel with the expression of striatal fos-related antigen immunoreactivity. The adenosine A2A receptor antagonist, 1,3,7-trimethyl-8-(3-chlorostyryl)-xanthine (0.5 or 1.0 mg/kg, i.p.), significantly reversed the pharmacological action of PAP 9704 in a dose related manner, but the adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dimethylxanthine (0.5 or 1.0 mg/kg, i.p.) and the A 2B receptor antagonist alloxazine (1.5 or 3.0 mg/kg, i.p.) did not significantly affect this pharmacological action. Our results suggest that PAP 9704 prevents MA-induced hyperlocomotion, at least in part, via the stimulation of the adenosine A2A receptor.

Original languageEnglish
Pages (from-to)906-909
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Volume27
Issue number6
DOIs
Publication statusPublished - 01-06-2004

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All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

Cite this

Kwon, Y. S., Nabeshima, T., Shin, E. J., Chun, W., Jhoo, J. H., Jhoo, W. K., Wie, M. B., Jang, C. G., Chung, H., Sung, Y. E., & Kim, H. C. (2004). PAP 9704, a Korean herbal medicine attenuates methamphetamine-induced hyperlocomotion via adenosine A2A receptor stimulation in mice. Biological and Pharmaceutical Bulletin, 27(6), 906-909. https://doi.org/10.1248/bpb.27.906