Parishin C attenuates phencyclidine-induced schizophrenia-like psychosis in mice: Involvements of 5-HT1A receptor

Eun Joo Shin, Wan Kyunn Whang, Sungun Kim, Jae Hyung Bach, Jin Man Kim, Xuan Khanh Thi Nguyen, Thuy Ty Lan Nguyen, Bae Dong Jung, Kiyofumi Yamada, Toshitaka Nabeshima, Hyoung Chun Kim

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Abstract

Parishin C, a major component of Gastrodia elata B LUME (GE), was purified from GE. Because GE modulates the serotonergic system and the 5-HT1A receptor is an important therapeutic target of schizophrenia, we examined whether parishin C affects phencyclidine-induced abnormal behaviors in mice. Phencyclidine-induced abnormal behaviors were significantly ameliorated by parishin C. These effects were reversed by WAY 100635, a 5-HT1A-receptor antagonist. Consistently, parishin C showed high affinity at 5-HT1A receptor as well as a 5-HT1A-agonist activity in a 8-OH-DPAT-stimulated [35 S]GTP-γS binding assay. Our results suggest that the antipsychotic effects of parishin C require activation of 5-HT1A receptors.

Original languageEnglish
Pages (from-to)404-408
Number of pages5
JournalJournal of Pharmacological Sciences
Volume113
Issue number4
DOIs
Publication statusPublished - 07-09-2010

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

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    Shin, E. J., Whang, W. K., Kim, S., Bach, J. H., Kim, J. M., Nguyen, X. K. T., Lan Nguyen, T. T., Jung, B. D., Yamada, K., Nabeshima, T., & Kim, H. C. (2010). Parishin C attenuates phencyclidine-induced schizophrenia-like psychosis in mice: Involvements of 5-HT1A receptor. Journal of Pharmacological Sciences, 113(4), 404-408. https://doi.org/10.1254/jphs.10040SC