Parishin C attenuates phencyclidine-induced schizophrenia-like psychosis in mice

Involvements of 5-HT1A receptor

Eun Joo Shin, Wan Kyunn Whang, Sungun Kim, Jae Hyung Bach, Jin Man Kim, Xuan Khanh Thi Nguyen, Thuy Ty Lan Nguyen, Bae Dong Jung, Kiyofumi Yamada, Toshitaka Nabeshima, Hyoung Chun Kim

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Parishin C, a major component of Gastrodia elata B LUME (GE), was purified from GE. Because GE modulates the serotonergic system and the 5-HT1A receptor is an important therapeutic target of schizophrenia, we examined whether parishin C affects phencyclidine-induced abnormal behaviors in mice. Phencyclidine-induced abnormal behaviors were significantly ameliorated by parishin C. These effects were reversed by WAY 100635, a 5-HT1A-receptor antagonist. Consistently, parishin C showed high affinity at 5-HT1A receptor as well as a 5-HT1A-agonist activity in a 8-OH-DPAT-stimulated [35 S]GTP-γS binding assay. Our results suggest that the antipsychotic effects of parishin C require activation of 5-HT1A receptors.

Original languageEnglish
Pages (from-to)404-408
Number of pages5
JournalJournal of Pharmacological Sciences
Volume113
Issue number4
DOIs
Publication statusPublished - 07-09-2010
Externally publishedYes

Fingerprint

Phencyclidine
Receptor, Serotonin, 5-HT1A
Psychotic Disorders
Schizophrenia
Gastrodia
Serotonin 5-HT1 Receptor Antagonists
Serotonin 5-HT1 Receptor Agonists
8-Hydroxy-2-(di-n-propylamino)tetralin
Guanosine Triphosphate
Antipsychotic Agents
parishin C

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Molecular Medicine

Cite this

Shin, E. J., Whang, W. K., Kim, S., Bach, J. H., Kim, J. M., Nguyen, X. K. T., ... Kim, H. C. (2010). Parishin C attenuates phencyclidine-induced schizophrenia-like psychosis in mice: Involvements of 5-HT1A receptor. Journal of Pharmacological Sciences, 113(4), 404-408. https://doi.org/10.1254/jphs.10040SC
Shin, Eun Joo ; Whang, Wan Kyunn ; Kim, Sungun ; Bach, Jae Hyung ; Kim, Jin Man ; Nguyen, Xuan Khanh Thi ; Lan Nguyen, Thuy Ty ; Jung, Bae Dong ; Yamada, Kiyofumi ; Nabeshima, Toshitaka ; Kim, Hyoung Chun. / Parishin C attenuates phencyclidine-induced schizophrenia-like psychosis in mice : Involvements of 5-HT1A receptor. In: Journal of Pharmacological Sciences. 2010 ; Vol. 113, No. 4. pp. 404-408.
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abstract = "Parishin C, a major component of Gastrodia elata B LUME (GE), was purified from GE. Because GE modulates the serotonergic system and the 5-HT1A receptor is an important therapeutic target of schizophrenia, we examined whether parishin C affects phencyclidine-induced abnormal behaviors in mice. Phencyclidine-induced abnormal behaviors were significantly ameliorated by parishin C. These effects were reversed by WAY 100635, a 5-HT1A-receptor antagonist. Consistently, parishin C showed high affinity at 5-HT1A receptor as well as a 5-HT1A-agonist activity in a 8-OH-DPAT-stimulated [35 S]GTP-γS binding assay. Our results suggest that the antipsychotic effects of parishin C require activation of 5-HT1A receptors.",
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Shin, EJ, Whang, WK, Kim, S, Bach, JH, Kim, JM, Nguyen, XKT, Lan Nguyen, TT, Jung, BD, Yamada, K, Nabeshima, T & Kim, HC 2010, 'Parishin C attenuates phencyclidine-induced schizophrenia-like psychosis in mice: Involvements of 5-HT1A receptor', Journal of Pharmacological Sciences, vol. 113, no. 4, pp. 404-408. https://doi.org/10.1254/jphs.10040SC

Parishin C attenuates phencyclidine-induced schizophrenia-like psychosis in mice : Involvements of 5-HT1A receptor. / Shin, Eun Joo; Whang, Wan Kyunn; Kim, Sungun; Bach, Jae Hyung; Kim, Jin Man; Nguyen, Xuan Khanh Thi; Lan Nguyen, Thuy Ty; Jung, Bae Dong; Yamada, Kiyofumi; Nabeshima, Toshitaka; Kim, Hyoung Chun.

In: Journal of Pharmacological Sciences, Vol. 113, No. 4, 07.09.2010, p. 404-408.

Research output: Contribution to journalArticle

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T2 - Involvements of 5-HT1A receptor

AU - Shin, Eun Joo

AU - Whang, Wan Kyunn

AU - Kim, Sungun

AU - Bach, Jae Hyung

AU - Kim, Jin Man

AU - Nguyen, Xuan Khanh Thi

AU - Lan Nguyen, Thuy Ty

AU - Jung, Bae Dong

AU - Yamada, Kiyofumi

AU - Nabeshima, Toshitaka

AU - Kim, Hyoung Chun

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