Patch Testing with Formaldehyde 2.0% (0.60 mg/cm2) Detects More Contact Allergy to Formaldehyde Than 1.0%

Marléne Isaksson, Iris Ale, Klaus E. Andersen, Chee Leok Goh, An Goossens, Hemangi Jerajani, Kayoko Matsunaga, John McFadden, Magnus Bruze

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Background The International Contact Dermatitis Research Group increased the patch test concentration of formaldehyde from 1.0% aqueous (aq) to 2.0% aq (in 2011). Objective This study was designed to investigate the outcome of the decision. Methods Consecutive dermatitis patients in 8 different clinics were patch tested with formaldehyde 1.0% aq and 2.0% aq. The test solutions were applied with a micropipette to the filter paper discs in the respective chamber. Results A total of 2778 patients were tested with 1.0% aq and 2766 to 2.0% aq. Sixty-five patients (2.3%, calculated from 2766 tested, to 2.0% aq) had positive patch test reactions interpreted as contact allergy to formaldehyde. This is a rather low frequency. Of these 65, 46 were women (46/1703 [2.7%]) and 19 were men (19/1063 [1.8%]). Thirty-six reacted only to 2.0% aq, 21 patients reacted to both concentrations, and 8 patients reacted only to 1.0% aq. Significantly, more patients reacted to 2.0% aq compared with 1.0% aq (P < 0.001). There was no significant sex difference. A total of 0.8% irritant reactions were recorded to formaldehyde 2.0% aq and 0.1% to 1.0% aq. Conclusions The increased formaldehyde patch test concentration to 2.0% aq revealed more formaldehyde contact allergy.

Original languageEnglish
Pages (from-to)342-346
Number of pages5
JournalDermatitis
Volume30
Issue number6
DOIs
Publication statusPublished - 01-11-2019

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Dermatology

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