Pathobiology and chemoprevention of bladder cancer

Takuji Tanaka, Katsuhito Miyazawa, Tetsuya Tsukamoto, Toshiya Kuno, Koji Suzuki

Research output: Contribution to journalReview article

20 Citations (Scopus)

Abstract

Our understanding of the pathogenesis of bladder cancer has improved considerably over the past decade. Translating these novel pathobiological discoveries into therapies, prevention, or strategies to manage patients who are suspected to have or who have been diagnosed with bladder cancer is the ultimate goal. In particular, the chemoprevention of bladder cancer development is important, since urothelial cancer frequently recurs, even if the primary cancer is completely removed. The numerous alterations of both oncogenes and tumor suppressor genes that have been implicated in bladder carcinogenesis represent novel targets for therapy and prevention. In addition, knowledge about these genetic alterations will help provide a better understanding of the biological significance of preneoplastic lesions of bladder cancer. Animal models for investigating bladder cancer development and prevention can also be developed based on these alterations. This paper summarizes the results of recent preclinical and clinical chemoprevention studies and discusses screening for bladder cancer.

Original languageEnglish
Article number528353
JournalJournal of Oncology
DOIs
Publication statusPublished - 24-11-2011

All Science Journal Classification (ASJC) codes

  • Oncology

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    Tanaka, T., Miyazawa, K., Tsukamoto, T., Kuno, T., & Suzuki, K. (2011). Pathobiology and chemoprevention of bladder cancer. Journal of Oncology, [528353]. https://doi.org/10.1155/2011/528353