Pathogenetic role of increased nasal resistance in obese patients with obstructive sleep apnea syndrome

Mitsuhiko Tagaya, Seiichi Nakata, Fumihiko Yasuma, Akiko Noda, Mami Morinaga, Hidehito Yagi, Makoto Sugiura, Masaaki Teranishi, Tsutomu Nakashima

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


Background: The role of increased nasal resistance in obstructive sleep apnea syndrome (OSAS) remains controversial. The aim of this study was to examine the pathogenetic role of nasal obstruction in obese patients with OSAS. Methods: Patients with OSAS (n = 125) at a university hospital were divided into three groups according to body mass index (BMI): nonobese (BMI < 25 kg/m2), mildly obese (25 kg/m2 ≤ BMI < 30 kg/m 2), and obese (BMI ≥ 30 kg/m2). The subjects underwent nasopharyngoscopy, measurement of nasal resistance, and polysomnography. Results: We studied 42 nonobese, 47 mildly obese, and 36 obese patients with OSAS. Among the obese, but not the nonobese and mildly obese patients, we found significant correlations between the oxygen desaturation index (ODI) and bilateral nasal resistance (BNR; r = 0.412; p = 0.013), between the ODI and unilateral higher nasal resistance (UHNR; r = 0.413; p = 0.012), and between the apnea index and UHNR (r = 0.334; p = 0.046). Multiple regression analysis incorporating all patients showed that BMI (p < 0.001) and BNR (p = 0.033) were independently related to the ODI. Conclusion: In obese patients with OSAS, increased nasal resistance could play an important pathogenetic role in hypoxemic apnea.

Original languageEnglish
Pages (from-to)51-54
Number of pages4
JournalAmerican Journal of Rhinology and Allergy
Issue number1
Publication statusPublished - 01-2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Otorhinolaryngology


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