Pathological analysis of Ki-67 and CD109 expression in tongue squamous cell carcinoma

Sumitaka Hagiwara, Noriyuki Yamamoto, Hiroki Furue, Hiroki Sakakura, Toshio Shigetomi, Yoshiki Murakumo, Hideharu Hibi, Masahide Takahashi, Minoru Ueda

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Objectives: The aims of the present study were to evaluate the correlation of Ki-67 and CD109 expression in tongue SCC (TSCC), and to confirm the utility of CD109 observation as a novel marker for cancer diagnosis. Material and methods: The expression of Ki-67 and CD109 from 27 patients with pathologically diagnosed well or moderately differentiated TSCC, including carcinoma in situ (CIS), was analyzed by immunohistochemical staining with anti-Ki-67 and anti-CD109 antibody. Significant relations between Ki-67 and CD109 expression were statistically assessed. Each expression level was quantified as a labeling index (LI). Results: Immunohistochemical staining revealed that the LI of CD109 was upregulated with that of Ki-67, and the highest LI of CD109 was frequently detected at 50-60% LI of Ki-67. Linear regression analysis showed a significant correlation between LI of Ki-67 and LI of CD109. In the group of low LI of Ki-67 less than 25%, CIS and some early invasive lesions indicated the high LI of CD109. Conclusions: These findings suggest that a positive relation exists between Ki-67 and CD109 expression in well or moderately differentiated TSCC including CIS, and immunohistochemical assessment of both expressions may well contribute to its pathological diagnosis. Moreover, CD109 could be one of the useful diagnostic markers for the detection of early-stage TSCC.

Original languageEnglish
Pages (from-to)276-281
Number of pages6
JournalJournal of Oral and Maxillofacial Surgery, Medicine, and Pathology
Issue number3
Publication statusPublished - 07-2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oral Surgery
  • Pathology and Forensic Medicine
  • Otorhinolaryngology


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