Pathological changes of the myocardium in reworsening of anthracycline-induced cardiomyopathy after explant of a left ventricular assist device

Hiroaki Hiraiwa, Takahiro Okumura, Shinya Shimizu, Yoshihito Arao, Hideo Oishi, Hiroo Kato, Tasuku Kuwayama, Shogo Yamaguchi, Tomoaki Haga, Tsuyoshi Yokoi, Toru Kondo, Yuki Sugiura, Naoaki Kano, Naoki Watanabe, Kenji Fukaya, Kenji Furusawa, Akinori Sawamura, Ryota Morimoto, Kazuro Fujimoto, Masato MutsugaAkihiko Usui, Toyoaki Murohara

Research output: Contribution to journalArticlepeer-review

Abstract

We herein report the long-term changes in cardiac function and pathological findings after successful explantation of a left ventricular assist device in a 42-year-old patient with anthracycline-induced cardiomyopathy with reworsening heart failure. Endomyocardial biopsy samples revealed that the cardiomyocyte diameter decreased and collagen volume fraction increased just after left ventricular assist device explantation. The collagen volume fraction decreased after 6 months, despite preserved systolic function. At 5 years after left ventricular assist device explantation, the systolic function markedly decreased and cardiomyocyte diameter increased. Pathological changes of the myocardium may enable the identification of cardiac dysfunction prior to echocardiographic changes in patients with reworsening heart failure after left ventricular assist device explantation.

Original languageEnglish
Pages (from-to)129-134
Number of pages6
JournalNagoya journal of medical science
Volume82
Issue number1
DOIs
Publication statusPublished - 01-02-2020
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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