Pathological changes of the myocardium in reworsening of anthracycline-induced cardiomyopathy after explant of a left ventricular assist device

Hiroaki Hiraiwa; Takahiro Okumura; Shinya Shimizu; Yoshihito Arao; Hideo Oishi; Hiroo Kato; Tasuku Kuwayama; Shogo Yamaguchi; Tomoaki Haga; Tsuyoshi Yokoi; Toru Kondo; Yuki Sugiura; Naoaki Kano; Naoki Watanabe; Kenji Fukaya; Kenji Furusawa; Akinori Sawamura; Ryota Morimoto; Kazuro Fujimoto; Masato Mutsuga; Akihiko Usui; Toyoaki Murohara

doi:10.18999/nagjms.82.1.129

Pathological changes of the myocardium in reworsening of anthracycline-induced cardiomyopathy after explant of a left ventricular assist device

Hiroaki Hiraiwa, Takahiro Okumura, Shinya Shimizu, Yoshihito Arao, Hideo Oishi, Hiroo Kato, Tasuku Kuwayama, Shogo Yamaguchi, Tomoaki Haga, Tsuyoshi Yokoi, Toru Kondo, Yuki Sugiura, Naoaki Kano, Naoki Watanabe, Kenji Fukaya, Kenji Furusawa, Akinori Sawamura, Ryota Morimoto, Kazuro Fujimoto, Masato MutsugaAkihiko Usui, Toyoaki Murohara

Internal Medicine

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Abstract

We herein report the long-term changes in cardiac function and pathological findings after successful explantation of a left ventricular assist device in a 42-year-old patient with anthracycline-induced cardiomyopathy with reworsening heart failure. Endomyocardial biopsy samples revealed that the cardiomyocyte diameter decreased and collagen volume fraction increased just after left ventricular assist device explantation. The collagen volume fraction decreased after 6 months, despite preserved systolic function. At 5 years after left ventricular assist device explantation, the systolic function markedly decreased and cardiomyocyte diameter increased. Pathological changes of the myocardium may enable the identification of cardiac dysfunction prior to echocardiographic changes in patients with reworsening heart failure after left ventricular assist device explantation.

Original language	English
Pages (from-to)	129-134
Number of pages	6
Journal	Nagoya journal of medical science
Volume	82
Issue number	1
DOIs	https://doi.org/10.18999/nagjms.82.1.129
Publication status	Published - 01-02-2020

All Science Journal Classification (ASJC) codes

General Medicine

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10.18999/nagjms.82.1.129

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Hiraiwa, H., Okumura, T., Shimizu, S., Arao, Y., Oishi, H., Kato, H., Kuwayama, T., Yamaguchi, S., Haga, T., Yokoi, T., Kondo, T., Sugiura, Y., Kano, N., Watanabe, N., Fukaya, K., Furusawa, K., Sawamura, A., Morimoto, R., Fujimoto, K., ... Murohara, T. (2020). Pathological changes of the myocardium in reworsening of anthracycline-induced cardiomyopathy after explant of a left ventricular assist device. Nagoya journal of medical science, 82(1), 129-134. https://doi.org/10.18999/nagjms.82.1.129

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title = "Pathological changes of the myocardium in reworsening of anthracycline-induced cardiomyopathy after explant of a left ventricular assist device",

abstract = "We herein report the long-term changes in cardiac function and pathological findings after successful explantation of a left ventricular assist device in a 42-year-old patient with anthracycline-induced cardiomyopathy with reworsening heart failure. Endomyocardial biopsy samples revealed that the cardiomyocyte diameter decreased and collagen volume fraction increased just after left ventricular assist device explantation. The collagen volume fraction decreased after 6 months, despite preserved systolic function. At 5 years after left ventricular assist device explantation, the systolic function markedly decreased and cardiomyocyte diameter increased. Pathological changes of the myocardium may enable the identification of cardiac dysfunction prior to echocardiographic changes in patients with reworsening heart failure after left ventricular assist device explantation.",

author = "Hiroaki Hiraiwa and Takahiro Okumura and Shinya Shimizu and Yoshihito Arao and Hideo Oishi and Hiroo Kato and Tasuku Kuwayama and Shogo Yamaguchi and Tomoaki Haga and Tsuyoshi Yokoi and Toru Kondo and Yuki Sugiura and Naoaki Kano and Naoki Watanabe and Kenji Fukaya and Kenji Furusawa and Akinori Sawamura and Ryota Morimoto and Kazuro Fujimoto and Masato Mutsuga and Akihiko Usui and Toyoaki Murohara",

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doi = "10.18999/nagjms.82.1.129",

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Hiraiwa, H, Okumura, T, Shimizu, S, Arao, Y, Oishi, H, Kato, H, Kuwayama, T, Yamaguchi, S, Haga, T, Yokoi, T, Kondo, T, Sugiura, Y, Kano, N, Watanabe, N, Fukaya, K, Furusawa, K, Sawamura, A, Morimoto, R, Fujimoto, K, Mutsuga, M, Usui, A & Murohara, T 2020, 'Pathological changes of the myocardium in reworsening of anthracycline-induced cardiomyopathy after explant of a left ventricular assist device', Nagoya journal of medical science, vol. 82, no. 1, pp. 129-134. https://doi.org/10.18999/nagjms.82.1.129

TY - JOUR

T1 - Pathological changes of the myocardium in reworsening of anthracycline-induced cardiomyopathy after explant of a left ventricular assist device

AU - Hiraiwa, Hiroaki

AU - Okumura, Takahiro

AU - Shimizu, Shinya

AU - Arao, Yoshihito

AU - Oishi, Hideo

AU - Kato, Hiroo

AU - Kuwayama, Tasuku

AU - Yamaguchi, Shogo

AU - Haga, Tomoaki

AU - Yokoi, Tsuyoshi

AU - Kondo, Toru

AU - Sugiura, Yuki

AU - Kano, Naoaki

AU - Watanabe, Naoki

AU - Fukaya, Kenji

AU - Furusawa, Kenji

AU - Sawamura, Akinori

AU - Morimoto, Ryota

AU - Fujimoto, Kazuro

AU - Mutsuga, Masato

AU - Usui, Akihiko

AU - Murohara, Toyoaki

PY - 2020/2/1

Y1 - 2020/2/1

N2 - We herein report the long-term changes in cardiac function and pathological findings after successful explantation of a left ventricular assist device in a 42-year-old patient with anthracycline-induced cardiomyopathy with reworsening heart failure. Endomyocardial biopsy samples revealed that the cardiomyocyte diameter decreased and collagen volume fraction increased just after left ventricular assist device explantation. The collagen volume fraction decreased after 6 months, despite preserved systolic function. At 5 years after left ventricular assist device explantation, the systolic function markedly decreased and cardiomyocyte diameter increased. Pathological changes of the myocardium may enable the identification of cardiac dysfunction prior to echocardiographic changes in patients with reworsening heart failure after left ventricular assist device explantation.

AB - We herein report the long-term changes in cardiac function and pathological findings after successful explantation of a left ventricular assist device in a 42-year-old patient with anthracycline-induced cardiomyopathy with reworsening heart failure. Endomyocardial biopsy samples revealed that the cardiomyocyte diameter decreased and collagen volume fraction increased just after left ventricular assist device explantation. The collagen volume fraction decreased after 6 months, despite preserved systolic function. At 5 years after left ventricular assist device explantation, the systolic function markedly decreased and cardiomyocyte diameter increased. Pathological changes of the myocardium may enable the identification of cardiac dysfunction prior to echocardiographic changes in patients with reworsening heart failure after left ventricular assist device explantation.

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Pathological changes of the myocardium in reworsening of anthracycline-induced cardiomyopathy after explant of a left ventricular assist device

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