Pathological complete remission of liver metastases correlates with elimination of tumor-infiltrating tregs in gastric Cancer

Yasutaka Nakanishi, Seiichi Hirota, Yudai Hojo, Tatsuro Nakamura, Tsutomu Kumamoto, Yasunori Kurahashi, Yoshinori Ishida, Hisashi Shinohara

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Background/Aim: Tumor-infiltrating Foxp3+ regulatory T-cells (Ti-Tregs) promote tumor progression and contribute to poor prognosis in gastric cancer, but the relationship between Ti-Tregs and response to chemotherapy for liver metastases from gastric cancer (LMGC) is unclear. We estimated the correlation between pathological response to chemotherapy and Ti-Tregs in LMGC. Patients and Methods: Ti-Tregs were analyzed with immunohistochemistry as CD3+ Foxp3+ cells in patients with synchronous LMGC. Results: Of 53 patients with LMGC, 49 received chemotherapy as initial treatment and 10 underwent R0 resection. LMGC disappeared pathologically in 5 resected cases despite radiologically residual disease. Ti-Tregs were found frequently in residual LMGC and primary lesions but rarely in tumor scar tissue. There was no relationship between frequency of CD8+ cells and pathological response. Conclusion: Marked reduction in Ti-Tregs correlates with pathological complete remission of LMGC. Ti-Tregs may be a biomarker to predict the effects of chemotherapy when used in combination with radiological findings.

Original languageEnglish
Pages (from-to)1571-1577
Number of pages7
JournalAnticancer research
Volume41
Issue number3
DOIs
Publication statusPublished - 03-2021
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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