Pathological complete response of colorectal liver metastases following chemotherapy with S-1 and oxaliplatin (SOX) in combination with bevacizumab: A case report

Tomoya Yokota, Tsuyoshi Sano, Yasuhiro Shimizu, Daisuke Takahari, Yoshiki Senda, Masahiro Shimura, Takashi Ura, Kohei Shitara, Yuji Nimura, Yasushi Yatabe, Kei Muro

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Abstract

Pathological complete response to systemic chemotherapy is associated with more favorable survival in patients with colorectal cancer liver metastases. We present a case of a 63-year-old man with multiple liver metastases from descending colon cancer. Following surgical resection of the primary tumor, the patient received systemic chemotherapy with S-1 and oxaliplatin in combination with bevacizumab. On achievement of a markedly favorable response to chemo- therapy, surgical treatment of liver metastases was performed, and the liver tumors were successfully resected without any macroscopic residue. Histopathological analyses showed necrotic tissue in the complete absence of residual viable tumor cells. This is the first reported case of a patient with multiple liver metastases from descending colorectal cancer to achieve a pathological complete response following systemic chemotherapy with S-1 and oxaliplatin in combination with bevacizumab. This regimen is a systemic chemotherapy option to 'cure' liver metastasis from colorectal cancer.

Original languageEnglish
Pages (from-to)201-205
Number of pages5
JournalOncology Letters
Volume2
Issue number2
DOIs
Publication statusPublished - 03-2011

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Yokota, T., Sano, T., Shimizu, Y., Takahari, D., Senda, Y., Shimura, M., Ura, T., Shitara, K., Nimura, Y., Yatabe, Y., & Muro, K. (2011). Pathological complete response of colorectal liver metastases following chemotherapy with S-1 and oxaliplatin (SOX) in combination with bevacizumab: A case report. Oncology Letters, 2(2), 201-205. https://doi.org/10.3892/ol.2011.256