TY - JOUR
T1 - Pathology-oriented treatment strategy of malignant ovarian tumor in pregnant women
T2 - analysis of 41 cases in Japan
AU - Morikawa, Asuka
AU - Ueda, Kazu
AU - Takahashi, Kazuaki
AU - Fukunaga, Masaharu
AU - Iwashita, Mitsutoshi
AU - Kobayashi, Yoichi
AU - Takechi, Kimihiro
AU - Umezawa, Satoshi
AU - Terauchi, Fumitoshi
AU - Kiguchi, Kazushige
AU - Aoki, Daisuke
AU - Nomura, Hiroyuki
AU - Yoshikawa, Hiroyuki
AU - Satoh, Toyomi
AU - Jobo, Toshiko
AU - Fujiwara, Hiroyuki
AU - Takei, Yuji
AU - Kamoi, Seiryu
AU - Terao, Yasuhisa
AU - Isonishi, Seiji
N1 - Publisher Copyright:
© 2014, Japan Society of Clinical Oncology.
PY - 2014/12/10
Y1 - 2014/12/10
N2 - Background: The aim of this study was to investigate the impact of the histological findings on the treatment of malignant ovarian tumors in pregnant women.Methods: This is a retrospective study of 41 patients diagnosed and treated for ovarian malignancy during pregnancy between 1985 and 2010.Results: The median age of the study group was 30 years old, ranging from 20 to 41. Thirty-eight (92 %) patients were diagnosed with stage I, and one (2 %) with each of stages II, III, and IV. Twenty-five (61 %) patients had borderline malignancy, 8 (20 %) were diagnosed with epithelial ovarian cancer, 7 (17 %) with germ cell tumor, and one with sex cord stromal tumor. All patients received primary surgery; 7 (17 %) patients had cystectomy, 32 (78 %) had unilateral salpingo-oophorectomy, and 3 (7 %) underwent hysterectomy with bilateral salpingo-oophorectomy. Thirty-one (76 %) patients delivered live newborns; 21 had borderline tumor (84 %), 2 had ovarian cancers (25 %), and 8 had non-epithelial tumor (100 %). Six cases were terminated in order to perform the standard treatment for ovarian malignancy and 2 cases aborted spontaneously.Conclusion: In pregnant women, ovarian cancer is exceptionally less frequent compared with non-pregnant women, i.e. age-matched, statistically-corrected controls based on the Japanese annual report [8/33 (24 %) vs. control (60 %); ovarian cancer/(ovarian cancer + borderline tumor), P = 0.001]. The pregnant women with ovarian cancer chose to prioritize treatment of ovarian cancer at the sacrifice of their babies while those with borderline tumor or non-epithelial tumor were able to successfully deliver live newborns.
AB - Background: The aim of this study was to investigate the impact of the histological findings on the treatment of malignant ovarian tumors in pregnant women.Methods: This is a retrospective study of 41 patients diagnosed and treated for ovarian malignancy during pregnancy between 1985 and 2010.Results: The median age of the study group was 30 years old, ranging from 20 to 41. Thirty-eight (92 %) patients were diagnosed with stage I, and one (2 %) with each of stages II, III, and IV. Twenty-five (61 %) patients had borderline malignancy, 8 (20 %) were diagnosed with epithelial ovarian cancer, 7 (17 %) with germ cell tumor, and one with sex cord stromal tumor. All patients received primary surgery; 7 (17 %) patients had cystectomy, 32 (78 %) had unilateral salpingo-oophorectomy, and 3 (7 %) underwent hysterectomy with bilateral salpingo-oophorectomy. Thirty-one (76 %) patients delivered live newborns; 21 had borderline tumor (84 %), 2 had ovarian cancers (25 %), and 8 had non-epithelial tumor (100 %). Six cases were terminated in order to perform the standard treatment for ovarian malignancy and 2 cases aborted spontaneously.Conclusion: In pregnant women, ovarian cancer is exceptionally less frequent compared with non-pregnant women, i.e. age-matched, statistically-corrected controls based on the Japanese annual report [8/33 (24 %) vs. control (60 %); ovarian cancer/(ovarian cancer + borderline tumor), P = 0.001]. The pregnant women with ovarian cancer chose to prioritize treatment of ovarian cancer at the sacrifice of their babies while those with borderline tumor or non-epithelial tumor were able to successfully deliver live newborns.
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U2 - 10.1007/s10147-014-0669-3
DO - 10.1007/s10147-014-0669-3
M3 - Article
C2 - 24534911
AN - SCOPUS:84917734427
SN - 1341-9625
VL - 19
SP - 1074
EP - 1079
JO - International Journal of Clinical Oncology
JF - International Journal of Clinical Oncology
IS - 6
ER -