Patients that have undergone hemodialysis exhibit lower amyloid deposition in the brain: Evidence supporting a therapeutic strategy for Alzheimer's disease by removal of blood amyloid

Kazuyoshi Sakai, Takao Senda, Ryuji Hata, Makoto Kuroda, Midori Hasegawa, Masao Kato, Masato Abe, Kazunori Kawaguchi, Shigeru Nakai, Yoshiyuki Hiki, Yukio Yuzawa, Nobuya Kitaguchi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

As a proof of concept that removal of blood amyloid-β (Aβ) can reduce Aβ deposition in the brains of patients with Alzheimer's disease, cortices of patients who had undergone hemodialysis (HD), which removes Aβ from the blood, were histochemically analyzed; postmortem brain sections were stained with anti-Aβ antibodies. Brains from patients who had undergone HD had significantly fewer senile plaques than those of patient who had not undergone HD.∗This significant difference was also confirmed by silver staining.∗Our findings suggest that removal of blood Aβ by hemodialysis results in lower accumulation of Aβ in the brain.

Original languageEnglish
Pages (from-to)997-1002
Number of pages6
JournalJournal of Alzheimer's Disease
Volume51
Issue number4
DOIs
Publication statusPublished - 12-04-2016

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Amyloid
Renal Dialysis
Alzheimer Disease
Brain
Silver Staining
Amyloid Plaques
Therapeutics
Anti-Idiotypic Antibodies

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

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abstract = "As a proof of concept that removal of blood amyloid-β (Aβ) can reduce Aβ deposition in the brains of patients with Alzheimer's disease, cortices of patients who had undergone hemodialysis (HD), which removes Aβ from the blood, were histochemically analyzed; postmortem brain sections were stained with anti-Aβ antibodies. Brains from patients who had undergone HD had significantly fewer senile plaques than those of patient who had not undergone HD.∗This significant difference was also confirmed by silver staining.∗Our findings suggest that removal of blood Aβ by hemodialysis results in lower accumulation of Aβ in the brain.",
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Patients that have undergone hemodialysis exhibit lower amyloid deposition in the brain : Evidence supporting a therapeutic strategy for Alzheimer's disease by removal of blood amyloid. / Sakai, Kazuyoshi; Senda, Takao; Hata, Ryuji; Kuroda, Makoto; Hasegawa, Midori; Kato, Masao; Abe, Masato; Kawaguchi, Kazunori; Nakai, Shigeru; Hiki, Yoshiyuki; Yuzawa, Yukio; Kitaguchi, Nobuya.

In: Journal of Alzheimer's Disease, Vol. 51, No. 4, 12.04.2016, p. 997-1002.

Research output: Contribution to journalArticle

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AU - Sakai, Kazuyoshi

AU - Senda, Takao

AU - Hata, Ryuji

AU - Kuroda, Makoto

AU - Hasegawa, Midori

AU - Kato, Masao

AU - Abe, Masato

AU - Kawaguchi, Kazunori

AU - Nakai, Shigeru

AU - Hiki, Yoshiyuki

AU - Yuzawa, Yukio

AU - Kitaguchi, Nobuya

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