Patients with CD36 deficiency are associated with enhanced atherosclerotic cardiovascular diseases

Miyako Yuasa-Kawase, Daisaku Masuda, Taiji Yamashita, Ryota Kawase, Hajime Nakaoka, Miwako Inagaki, Kazuhiro Nakatani, Kazumi Tsubakio-Yamamoto, Tohru Ohama, Akifumi Matsuyama, Makoto Nishida, Masato Ishigami, Toshiharu Kawamoto, Issei Komuro, Shizuya Yamashita

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Abstract

Aim: The clustering of dyslipidemia, impaired glucose tolerance and hypertension increases the morbidity and mortality from cardiovascular events. A class B scavenger receptor, CD36, is a receptor for oxidized LDL and a transporter of long-chain fatty acids. Because of the impaired uptake of oxidized LDL in CD36-deficient macrophages and from the results of CD36 knockout mice, CD36 deficiency (CD36-D) was supposed to be associated with reduced risks for coronary artery disease (CAD); however, CD36-D patients are often accompanied by a clustering of coronary risk factors. The current study aimed to investigate the morbidity and severity of cardiovascular diseases in CD36-D patients. Methods: By screening for CD36 antigen on platelets and monocytes using FACS or the absent myocardial accumulation of 123 I-BMIPP by scintigraphy, 40 patients with type I CD36-D were collected, the morbidity of CAD and their features of atherosclerotic cardiovascular diseases were observed. Screening for CD36-D in both CAD patients (n = 319) and healthy subjects (n = 1,239) were underwent. Results: The morbidity of CAD was significantly higher in CD36-D patients than in the general population; 50% of patients (20 out of 40) had CAD identified by BMIPP scintigraphy and 37.5% (3 out of 8) by FACS screening, respectively. Three representative CD36-D cases demonstrated severe CAD and atherosclerosis. The frequency of CD36-D was three times higher in CAD patients than in healthy subjects (0.9% vs 0.3%, p<0.0001). Conclusion: The morbidity of CAD is significantly higher in CD36-D patients suffering from severe atherosclerosis, implying that the status of CD36-D might be atherogenic.

Original languageEnglish
Pages (from-to)263-275
Number of pages13
JournalJournal of atherosclerosis and thrombosis
Volume19
Issue number3
DOIs
Publication statusPublished - 02-04-2012

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All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Biochemistry, medical

Cite this

Yuasa-Kawase, M., Masuda, D., Yamashita, T., Kawase, R., Nakaoka, H., Inagaki, M., Nakatani, K., Tsubakio-Yamamoto, K., Ohama, T., Matsuyama, A., Nishida, M., Ishigami, M., Kawamoto, T., Komuro, I., & Yamashita, S. (2012). Patients with CD36 deficiency are associated with enhanced atherosclerotic cardiovascular diseases. Journal of atherosclerosis and thrombosis, 19(3), 263-275. https://doi.org/10.5551/jat.10603