TY - JOUR
T1 - Peach (Prunus persica) extract inhibits angiotensin II-induced signal transduction in vascular smooth muscle cells
AU - Kono, Ryohei
AU - Okuno, Yoshiharu
AU - Nakamura, Misa
AU - Inada, Ken Ichi
AU - Tokuda, Akihiko
AU - Yamashita, Miki
AU - Hidaka, Ryu
AU - Utsunomiya, Hirotoshi
PY - 2013/8/15
Y1 - 2013/8/15
N2 - Angiotensin II (Ang II) is a vasoactive hormone that has been implicated in cardiovascular diseases. Here, the effect of peach, Prunus persica L. Batsch, pulp extract on Ang II-induced intracellular Ca2+ mobilization, reactive oxygen species (ROS) production and signal transduction events in cultured vascular smooth muscle cells (VSMCs) was investigated. Pretreatment of peach ethyl acetate extract inhibited Ang II-induced intracellular Ca 2+ elevation in VSMCs. Furthermore, Ang II-induced ROS generation, essential for signal transduction events, was diminished by the peach ethyl acetate extract. The peach ethyl acetate extract also attenuated the Ang II-induced phosphorylation of epidermal growth factor receptor and myosin phosphatase target subunit 1, both of which are associated with atherosclerosis and hypertension. These results suggest that peach ethyl acetate extract may have clinical potential for preventing cardiovascular diseases by interfering with Ang II-induced intracellular Ca2+ elevation, the generation of ROS, and then blocking signal transduction events.
AB - Angiotensin II (Ang II) is a vasoactive hormone that has been implicated in cardiovascular diseases. Here, the effect of peach, Prunus persica L. Batsch, pulp extract on Ang II-induced intracellular Ca2+ mobilization, reactive oxygen species (ROS) production and signal transduction events in cultured vascular smooth muscle cells (VSMCs) was investigated. Pretreatment of peach ethyl acetate extract inhibited Ang II-induced intracellular Ca 2+ elevation in VSMCs. Furthermore, Ang II-induced ROS generation, essential for signal transduction events, was diminished by the peach ethyl acetate extract. The peach ethyl acetate extract also attenuated the Ang II-induced phosphorylation of epidermal growth factor receptor and myosin phosphatase target subunit 1, both of which are associated with atherosclerosis and hypertension. These results suggest that peach ethyl acetate extract may have clinical potential for preventing cardiovascular diseases by interfering with Ang II-induced intracellular Ca2+ elevation, the generation of ROS, and then blocking signal transduction events.
UR - http://www.scopus.com/inward/record.url?scp=84875961552&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875961552&partnerID=8YFLogxK
U2 - 10.1016/j.foodchem.2013.02.019
DO - 10.1016/j.foodchem.2013.02.019
M3 - Article
C2 - 23561119
AN - SCOPUS:84875961552
SN - 0308-8146
VL - 139
SP - 371
EP - 376
JO - Food Chemistry
JF - Food Chemistry
IS - 1-4
ER -
