Pegylated interferon monotherapy in patients with chronic hepatitis C with low viremia and its relationship to mutations in the NS5A region and the single nucleotide polymorphism of interleukin-28B

Kazuhiko Hayashi, Yoshiaki Katano, Hiroko Masuda, Youji Ishizu, Teiji Kuzuya, Takashi Honda, Masatoshi Ishigami, Akihiro Itoh, Yoshiki Hirooka, Isao Nakano, Tetsuya Ishikawa, Fumihiro Urano, Kentaro Yoshioka, Hidenori Toyoda, Takashi Kumada, Hidemi Goto

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Aim: Previous studies have suggested that patients with chronic hepatitis C with a low pretreatment hepatitis C virus (HCV) level have a high sustained virological response (SVR) rate, and that there would be a subpopulation of patients in which HCV can be eradicated with pegylated interferon (PEG IFN) alone without a decrease in SVR. However, the efficacy of PEG IFN monotherapy in patients with low HCV RNA levels is unclear. Several studies have reported that interferon sensitivity-determining region (ISDR) and the single-nucleotide polymorphism (SNP) of interleukin-28B (IL-28B) contribute to IFN response, but these relationships are controversial. The aim of this study was to determine whether the SNP of IL-28B (rs8099917) and amino acid substitutions in the ISDR among patients with low HCV levels affect the response to PEG IFN monotherapy. Methods: One hundred and four patients with low-level HCV infection were studied. Low HCV level was defined as 100KIU/mL or less. Results: SVR was achieved in 94 patients (92.2%). HCV levels (≤50KIU/mL) and ISDR (≥2 mutations) were associated with SVR on univariate analysis. The rates of SVR in the patients with IL-28B genotypes TT, TG and GG were 94.5%, 77.8% and 100%, respectively. The G allele tended to be associated with poor response to IFN therapy (P=0.0623). On multivariate analysis, the ISDR was the factor predictive of SVR (P=0.004). Conclusion: The ISDR is significantly associated with a good response to PEG IFN monotherapy in patients with low HCV levels.

Original languageEnglish
Pages (from-to)580-588
Number of pages9
JournalHepatology Research
Volume43
Issue number6
DOIs
Publication statusPublished - 06-2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Infectious Diseases

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