TY - JOUR
T1 - Penicillin-susceptible group B streptococcal clinical isolates with reduced cephalosporin susceptibility
AU - Nagano, Noriyuki
AU - Nagano, Yukiko
AU - Toyama, Masami
AU - Kimura, Kouji
AU - Shibayama, Keigo
AU - Arakawa, Yoshichika
PY - 2014/9
Y1 - 2014/9
N2 - We characterized penicillin-susceptible group B streptococcal (PSGBS) clinical isolates exhibiting no growth inhibition zone around a ceftibuten disk (CTBr PSGBS). The CTBr PSGBS isolates, for which augmented MICs of cefaclor and ceftizoxime were found, shared a T394A substitution in penicillin-binding protein 2X (PBP 2X) and a T567I substitution in PBP 2B, together with an additional G429S substitution in PBP 2X or a T145A substitution in PBP 1A, although the T145A substitution in the transglycosidase domain of PBP 1A would have no effect on the level of resistance to ceftibuten.
AB - We characterized penicillin-susceptible group B streptococcal (PSGBS) clinical isolates exhibiting no growth inhibition zone around a ceftibuten disk (CTBr PSGBS). The CTBr PSGBS isolates, for which augmented MICs of cefaclor and ceftizoxime were found, shared a T394A substitution in penicillin-binding protein 2X (PBP 2X) and a T567I substitution in PBP 2B, together with an additional G429S substitution in PBP 2X or a T145A substitution in PBP 1A, although the T145A substitution in the transglycosidase domain of PBP 1A would have no effect on the level of resistance to ceftibuten.
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U2 - 10.1128/JCM.01291-14
DO - 10.1128/JCM.01291-14
M3 - Article
C2 - 24920773
AN - SCOPUS:84906875647
SN - 0095-1137
VL - 52
SP - 3406
EP - 3410
JO - Journal of clinical microbiology
JF - Journal of clinical microbiology
IS - 9
ER -