Penicillin-susceptible group B streptococcal clinical isolates with reduced cephalosporin susceptibility

Noriyuki Nagano; Yukiko Nagano; Masami Toyama; Kouji Kimura; Keigo Shibayama; Yoshichika Arakawa

doi:10.1128/JCM.01291-14

Penicillin-susceptible group B streptococcal clinical isolates with reduced cephalosporin susceptibility

Noriyuki Nagano
, Yukiko Nagano
, Masami Toyama
, Kouji Kimura
, Keigo Shibayama
, Yoshichika Arakawa

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

We characterized penicillin-susceptible group B streptococcal (PSGBS) clinical isolates exhibiting no growth inhibition zone around a ceftibuten disk (CTB^r PSGBS). The CTB^r PSGBS isolates, for which augmented MICs of cefaclor and ceftizoxime were found, shared a T394A substitution in penicillin-binding protein 2X (PBP 2X) and a T567I substitution in PBP 2B, together with an additional G429S substitution in PBP 2X or a T145A substitution in PBP 1A, although the T145A substitution in the transglycosidase domain of PBP 1A would have no effect on the level of resistance to ceftibuten.

Original language	English
Pages (from-to)	3406-3410
Number of pages	5
Journal	Journal of clinical microbiology
Volume	52
Issue number	9
DOIs	https://doi.org/10.1128/JCM.01291-14
Publication status	Published - 09-2014
Externally published	Yes

All Science Journal Classification (ASJC) codes

Microbiology (medical)

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abstract = "We characterized penicillin-susceptible group B streptococcal (PSGBS) clinical isolates exhibiting no growth inhibition zone around a ceftibuten disk (CTBr PSGBS). The CTBr PSGBS isolates, for which augmented MICs of cefaclor and ceftizoxime were found, shared a T394A substitution in penicillin-binding protein 2X (PBP 2X) and a T567I substitution in PBP 2B, together with an additional G429S substitution in PBP 2X or a T145A substitution in PBP 1A, although the T145A substitution in the transglycosidase domain of PBP 1A would have no effect on the level of resistance to ceftibuten.",

author = "Noriyuki Nagano and Yukiko Nagano and Masami Toyama and Kouji Kimura and Keigo Shibayama and Yoshichika Arakawa",

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T1 - Penicillin-susceptible group B streptococcal clinical isolates with reduced cephalosporin susceptibility

AU - Nagano, Noriyuki

AU - Nagano, Yukiko

AU - Toyama, Masami

AU - Kimura, Kouji

AU - Shibayama, Keigo

AU - Arakawa, Yoshichika

PY - 2014/9

Y1 - 2014/9

N2 - We characterized penicillin-susceptible group B streptococcal (PSGBS) clinical isolates exhibiting no growth inhibition zone around a ceftibuten disk (CTBr PSGBS). The CTBr PSGBS isolates, for which augmented MICs of cefaclor and ceftizoxime were found, shared a T394A substitution in penicillin-binding protein 2X (PBP 2X) and a T567I substitution in PBP 2B, together with an additional G429S substitution in PBP 2X or a T145A substitution in PBP 1A, although the T145A substitution in the transglycosidase domain of PBP 1A would have no effect on the level of resistance to ceftibuten.

AB - We characterized penicillin-susceptible group B streptococcal (PSGBS) clinical isolates exhibiting no growth inhibition zone around a ceftibuten disk (CTBr PSGBS). The CTBr PSGBS isolates, for which augmented MICs of cefaclor and ceftizoxime were found, shared a T394A substitution in penicillin-binding protein 2X (PBP 2X) and a T567I substitution in PBP 2B, together with an additional G429S substitution in PBP 2X or a T145A substitution in PBP 1A, although the T145A substitution in the transglycosidase domain of PBP 1A would have no effect on the level of resistance to ceftibuten.

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JO - Journal of clinical microbiology

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Penicillin-susceptible group B streptococcal clinical isolates with reduced cephalosporin susceptibility

Abstract

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