Perceived mental stress and mortality from cardiovascular disease among Japanese men and women: The Japan Collaborative Cohort Study for Evaluation of Cancer Risk Sponsored by Monbusho (JACC Study)

Hiroyasu Iso, Chigusa Date, Akio Yamamoto, Hideaki Toyoshima, Naohito Tanabe, Shogo Kikuchi, Takaaki Kondo, Yoshiyuki Watanabe, Yasuhiko Wada, Teruo Ishibashi, Hiroshi Suzuki, Akio Koizumi, Yutaka Inaba, Akiko Tamakoshi, Yoshiyuki Ohno, Mitsuru Mori, Yutaka Motohashi, Shigeru Hisamichi, Yosikazu Nakamura, Haruo MikamiShuji Hashimoto, Yoshiharu Hoshiyama, Hiroyuki Shimizu, Shinkan Tokudome, Yoshinori Ito, Takashi Kawamura, Masahiro Nakao, Takaichiro Suzuki, Tsutomo Hashimoto, Takayuki Nose, Norihiko Hayakawa, Takesumi Yoshimura, Katsuhiro Fukuda, Naoyuki Okamoto, Hideo Shio, Tomoyuki Kitagawa, Toshio Kuroki, Kazuo Tajima

Research output: Contribution to journalArticle

165 Citations (Scopus)

Abstract

Background - Perceived mental stress has been associated with risk of coronary heart disease (CHD) in white men, but no prospective data are available for other ethnic groups. Methods and Results - From 1988 to 1990, a total of 73 424 Japanese (30 180 men and 43 244 women), aged 40 to 79 years, without a history of stroke, CHD, or cancer completed a lifestyle questionnaire including perception of mental stress under the Japan Collaborative Cohort Study for Evaluation of Cancer Risk Sponsored by Monbusho (JACC Study). Systematic surveillance was completed until the end of 1997, with a 580 378 person-year follow-up, and the underlying causes of death were determined according to the International Classification of Diseases, 10th revision. For women, there were 316 with total stroke, 113 with CHD, and 643 with total cardiovascular disease (CVD); for men, there were 341, 168, and 778, respectively. Women who reported high stress had a 2-fold higher age-adjusted risk of mortality from total stroke and CHD and 1.5-fold higher risk of total CVD compared with those who reported low stress. Further adjustment for known cardiovascular risk factors and selected psychological variables did not alter the associations materially. The multivariate relative risk for women who perceived high stress versus low stress was 2.24 (95% CI 1.52 to 3.31, P<0.001) for total stroke, 2.28 (95% CI 1.17 to 4.43, P=0.02) for CHD, and 1.64 (95% CI 1.25 to 2.16, P<0.001) for total CVD. For men, these relations were generally weaker but suggestive of myocardial infarction. Conclusions - Perceived mental stress was associated with increased mortality from stroke for women and with CHD for men and women.

Original languageEnglish
Pages (from-to)1229-1236
Number of pages8
JournalCirculation
Volume106
Issue number10
DOIs
Publication statusPublished - 03-09-2002

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Coronary Disease
Japan
Cohort Studies
Cardiovascular Diseases
Stroke
Mortality
Neoplasms
Heart Neoplasms
International Classification of Diseases
Ethnic Groups
Life Style
Cause of Death
Myocardial Infarction
Psychology

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Iso, Hiroyasu ; Date, Chigusa ; Yamamoto, Akio ; Toyoshima, Hideaki ; Tanabe, Naohito ; Kikuchi, Shogo ; Kondo, Takaaki ; Watanabe, Yoshiyuki ; Wada, Yasuhiko ; Ishibashi, Teruo ; Suzuki, Hiroshi ; Koizumi, Akio ; Inaba, Yutaka ; Tamakoshi, Akiko ; Ohno, Yoshiyuki ; Mori, Mitsuru ; Motohashi, Yutaka ; Hisamichi, Shigeru ; Nakamura, Yosikazu ; Mikami, Haruo ; Hashimoto, Shuji ; Hoshiyama, Yoshiharu ; Shimizu, Hiroyuki ; Tokudome, Shinkan ; Ito, Yoshinori ; Kawamura, Takashi ; Nakao, Masahiro ; Suzuki, Takaichiro ; Hashimoto, Tsutomo ; Nose, Takayuki ; Hayakawa, Norihiko ; Yoshimura, Takesumi ; Fukuda, Katsuhiro ; Okamoto, Naoyuki ; Shio, Hideo ; Kitagawa, Tomoyuki ; Kuroki, Toshio ; Tajima, Kazuo. / Perceived mental stress and mortality from cardiovascular disease among Japanese men and women : The Japan Collaborative Cohort Study for Evaluation of Cancer Risk Sponsored by Monbusho (JACC Study). In: Circulation. 2002 ; Vol. 106, No. 10. pp. 1229-1236.
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abstract = "Background - Perceived mental stress has been associated with risk of coronary heart disease (CHD) in white men, but no prospective data are available for other ethnic groups. Methods and Results - From 1988 to 1990, a total of 73 424 Japanese (30 180 men and 43 244 women), aged 40 to 79 years, without a history of stroke, CHD, or cancer completed a lifestyle questionnaire including perception of mental stress under the Japan Collaborative Cohort Study for Evaluation of Cancer Risk Sponsored by Monbusho (JACC Study). Systematic surveillance was completed until the end of 1997, with a 580 378 person-year follow-up, and the underlying causes of death were determined according to the International Classification of Diseases, 10th revision. For women, there were 316 with total stroke, 113 with CHD, and 643 with total cardiovascular disease (CVD); for men, there were 341, 168, and 778, respectively. Women who reported high stress had a 2-fold higher age-adjusted risk of mortality from total stroke and CHD and 1.5-fold higher risk of total CVD compared with those who reported low stress. Further adjustment for known cardiovascular risk factors and selected psychological variables did not alter the associations materially. The multivariate relative risk for women who perceived high stress versus low stress was 2.24 (95{\%} CI 1.52 to 3.31, P<0.001) for total stroke, 2.28 (95{\%} CI 1.17 to 4.43, P=0.02) for CHD, and 1.64 (95{\%} CI 1.25 to 2.16, P<0.001) for total CVD. For men, these relations were generally weaker but suggestive of myocardial infarction. Conclusions - Perceived mental stress was associated with increased mortality from stroke for women and with CHD for men and women.",
author = "Hiroyasu Iso and Chigusa Date and Akio Yamamoto and Hideaki Toyoshima and Naohito Tanabe and Shogo Kikuchi and Takaaki Kondo and Yoshiyuki Watanabe and Yasuhiko Wada and Teruo Ishibashi and Hiroshi Suzuki and Akio Koizumi and Yutaka Inaba and Akiko Tamakoshi and Yoshiyuki Ohno and Mitsuru Mori and Yutaka Motohashi and Shigeru Hisamichi and Yosikazu Nakamura and Haruo Mikami and Shuji Hashimoto and Yoshiharu Hoshiyama and Hiroyuki Shimizu and Shinkan Tokudome and Yoshinori Ito and Takashi Kawamura and Masahiro Nakao and Takaichiro Suzuki and Tsutomo Hashimoto and Takayuki Nose and Norihiko Hayakawa and Takesumi Yoshimura and Katsuhiro Fukuda and Naoyuki Okamoto and Hideo Shio and Tomoyuki Kitagawa and Toshio Kuroki and Kazuo Tajima",
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Iso, H, Date, C, Yamamoto, A, Toyoshima, H, Tanabe, N, Kikuchi, S, Kondo, T, Watanabe, Y, Wada, Y, Ishibashi, T, Suzuki, H, Koizumi, A, Inaba, Y, Tamakoshi, A, Ohno, Y, Mori, M, Motohashi, Y, Hisamichi, S, Nakamura, Y, Mikami, H, Hashimoto, S, Hoshiyama, Y, Shimizu, H, Tokudome, S, Ito, Y, Kawamura, T, Nakao, M, Suzuki, T, Hashimoto, T, Nose, T, Hayakawa, N, Yoshimura, T, Fukuda, K, Okamoto, N, Shio, H, Kitagawa, T, Kuroki, T & Tajima, K 2002, 'Perceived mental stress and mortality from cardiovascular disease among Japanese men and women: The Japan Collaborative Cohort Study for Evaluation of Cancer Risk Sponsored by Monbusho (JACC Study)', Circulation, vol. 106, no. 10, pp. 1229-1236. https://doi.org/10.1161/01.CIR.0000028145.58654.41

Perceived mental stress and mortality from cardiovascular disease among Japanese men and women : The Japan Collaborative Cohort Study for Evaluation of Cancer Risk Sponsored by Monbusho (JACC Study). / Iso, Hiroyasu; Date, Chigusa; Yamamoto, Akio; Toyoshima, Hideaki; Tanabe, Naohito; Kikuchi, Shogo; Kondo, Takaaki; Watanabe, Yoshiyuki; Wada, Yasuhiko; Ishibashi, Teruo; Suzuki, Hiroshi; Koizumi, Akio; Inaba, Yutaka; Tamakoshi, Akiko; Ohno, Yoshiyuki; Mori, Mitsuru; Motohashi, Yutaka; Hisamichi, Shigeru; Nakamura, Yosikazu; Mikami, Haruo; Hashimoto, Shuji; Hoshiyama, Yoshiharu; Shimizu, Hiroyuki; Tokudome, Shinkan; Ito, Yoshinori; Kawamura, Takashi; Nakao, Masahiro; Suzuki, Takaichiro; Hashimoto, Tsutomo; Nose, Takayuki; Hayakawa, Norihiko; Yoshimura, Takesumi; Fukuda, Katsuhiro; Okamoto, Naoyuki; Shio, Hideo; Kitagawa, Tomoyuki; Kuroki, Toshio; Tajima, Kazuo.

In: Circulation, Vol. 106, No. 10, 03.09.2002, p. 1229-1236.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Perceived mental stress and mortality from cardiovascular disease among Japanese men and women

T2 - The Japan Collaborative Cohort Study for Evaluation of Cancer Risk Sponsored by Monbusho (JACC Study)

AU - Iso, Hiroyasu

AU - Date, Chigusa

AU - Yamamoto, Akio

AU - Toyoshima, Hideaki

AU - Tanabe, Naohito

AU - Kikuchi, Shogo

AU - Kondo, Takaaki

AU - Watanabe, Yoshiyuki

AU - Wada, Yasuhiko

AU - Ishibashi, Teruo

AU - Suzuki, Hiroshi

AU - Koizumi, Akio

AU - Inaba, Yutaka

AU - Tamakoshi, Akiko

AU - Ohno, Yoshiyuki

AU - Mori, Mitsuru

AU - Motohashi, Yutaka

AU - Hisamichi, Shigeru

AU - Nakamura, Yosikazu

AU - Mikami, Haruo

AU - Hashimoto, Shuji

AU - Hoshiyama, Yoshiharu

AU - Shimizu, Hiroyuki

AU - Tokudome, Shinkan

AU - Ito, Yoshinori

AU - Kawamura, Takashi

AU - Nakao, Masahiro

AU - Suzuki, Takaichiro

AU - Hashimoto, Tsutomo

AU - Nose, Takayuki

AU - Hayakawa, Norihiko

AU - Yoshimura, Takesumi

AU - Fukuda, Katsuhiro

AU - Okamoto, Naoyuki

AU - Shio, Hideo

AU - Kitagawa, Tomoyuki

AU - Kuroki, Toshio

AU - Tajima, Kazuo

PY - 2002/9/3

Y1 - 2002/9/3

N2 - Background - Perceived mental stress has been associated with risk of coronary heart disease (CHD) in white men, but no prospective data are available for other ethnic groups. Methods and Results - From 1988 to 1990, a total of 73 424 Japanese (30 180 men and 43 244 women), aged 40 to 79 years, without a history of stroke, CHD, or cancer completed a lifestyle questionnaire including perception of mental stress under the Japan Collaborative Cohort Study for Evaluation of Cancer Risk Sponsored by Monbusho (JACC Study). Systematic surveillance was completed until the end of 1997, with a 580 378 person-year follow-up, and the underlying causes of death were determined according to the International Classification of Diseases, 10th revision. For women, there were 316 with total stroke, 113 with CHD, and 643 with total cardiovascular disease (CVD); for men, there were 341, 168, and 778, respectively. Women who reported high stress had a 2-fold higher age-adjusted risk of mortality from total stroke and CHD and 1.5-fold higher risk of total CVD compared with those who reported low stress. Further adjustment for known cardiovascular risk factors and selected psychological variables did not alter the associations materially. The multivariate relative risk for women who perceived high stress versus low stress was 2.24 (95% CI 1.52 to 3.31, P<0.001) for total stroke, 2.28 (95% CI 1.17 to 4.43, P=0.02) for CHD, and 1.64 (95% CI 1.25 to 2.16, P<0.001) for total CVD. For men, these relations were generally weaker but suggestive of myocardial infarction. Conclusions - Perceived mental stress was associated with increased mortality from stroke for women and with CHD for men and women.

AB - Background - Perceived mental stress has been associated with risk of coronary heart disease (CHD) in white men, but no prospective data are available for other ethnic groups. Methods and Results - From 1988 to 1990, a total of 73 424 Japanese (30 180 men and 43 244 women), aged 40 to 79 years, without a history of stroke, CHD, or cancer completed a lifestyle questionnaire including perception of mental stress under the Japan Collaborative Cohort Study for Evaluation of Cancer Risk Sponsored by Monbusho (JACC Study). Systematic surveillance was completed until the end of 1997, with a 580 378 person-year follow-up, and the underlying causes of death were determined according to the International Classification of Diseases, 10th revision. For women, there were 316 with total stroke, 113 with CHD, and 643 with total cardiovascular disease (CVD); for men, there were 341, 168, and 778, respectively. Women who reported high stress had a 2-fold higher age-adjusted risk of mortality from total stroke and CHD and 1.5-fold higher risk of total CVD compared with those who reported low stress. Further adjustment for known cardiovascular risk factors and selected psychological variables did not alter the associations materially. The multivariate relative risk for women who perceived high stress versus low stress was 2.24 (95% CI 1.52 to 3.31, P<0.001) for total stroke, 2.28 (95% CI 1.17 to 4.43, P=0.02) for CHD, and 1.64 (95% CI 1.25 to 2.16, P<0.001) for total CVD. For men, these relations were generally weaker but suggestive of myocardial infarction. Conclusions - Perceived mental stress was associated with increased mortality from stroke for women and with CHD for men and women.

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