TY - JOUR
T1 - Perceived mental stress and mortality from cardiovascular disease among Japanese men and women
T2 - The Japan Collaborative Cohort Study for Evaluation of Cancer Risk Sponsored by Monbusho (JACC Study)
AU - Iso, Hiroyasu
AU - Date, Chigusa
AU - Yamamoto, Akio
AU - Toyoshima, Hideaki
AU - Tanabe, Naohito
AU - Kikuchi, Shogo
AU - Kondo, Takaaki
AU - Watanabe, Yoshiyuki
AU - Wada, Yasuhiko
AU - Ishibashi, Teruo
AU - Suzuki, Hiroshi
AU - Koizumi, Akio
AU - Inaba, Yutaka
AU - Tamakoshi, Akiko
AU - Ohno, Yoshiyuki
AU - Mori, Mitsuru
AU - Motohashi, Yutaka
AU - Hisamichi, Shigeru
AU - Nakamura, Yosikazu
AU - Mikami, Haruo
AU - Hashimoto, Shuji
AU - Hoshiyama, Yoshiharu
AU - Shimizu, Hiroyuki
AU - Tokudome, Shinkan
AU - Ito, Yoshinori
AU - Kawamura, Takashi
AU - Nakao, Masahiro
AU - Suzuki, Takaichiro
AU - Hashimoto, Tsutomo
AU - Nose, Takayuki
AU - Hayakawa, Norihiko
AU - Yoshimura, Takesumi
AU - Fukuda, Katsuhiro
AU - Okamoto, Naoyuki
AU - Shio, Hideo
AU - Kitagawa, Tomoyuki
AU - Kuroki, Toshio
AU - Tajima, Kazuo
PY - 2002/9/3
Y1 - 2002/9/3
N2 - Background - Perceived mental stress has been associated with risk of coronary heart disease (CHD) in white men, but no prospective data are available for other ethnic groups. Methods and Results - From 1988 to 1990, a total of 73 424 Japanese (30 180 men and 43 244 women), aged 40 to 79 years, without a history of stroke, CHD, or cancer completed a lifestyle questionnaire including perception of mental stress under the Japan Collaborative Cohort Study for Evaluation of Cancer Risk Sponsored by Monbusho (JACC Study). Systematic surveillance was completed until the end of 1997, with a 580 378 person-year follow-up, and the underlying causes of death were determined according to the International Classification of Diseases, 10th revision. For women, there were 316 with total stroke, 113 with CHD, and 643 with total cardiovascular disease (CVD); for men, there were 341, 168, and 778, respectively. Women who reported high stress had a 2-fold higher age-adjusted risk of mortality from total stroke and CHD and 1.5-fold higher risk of total CVD compared with those who reported low stress. Further adjustment for known cardiovascular risk factors and selected psychological variables did not alter the associations materially. The multivariate relative risk for women who perceived high stress versus low stress was 2.24 (95% CI 1.52 to 3.31, P<0.001) for total stroke, 2.28 (95% CI 1.17 to 4.43, P=0.02) for CHD, and 1.64 (95% CI 1.25 to 2.16, P<0.001) for total CVD. For men, these relations were generally weaker but suggestive of myocardial infarction. Conclusions - Perceived mental stress was associated with increased mortality from stroke for women and with CHD for men and women.
AB - Background - Perceived mental stress has been associated with risk of coronary heart disease (CHD) in white men, but no prospective data are available for other ethnic groups. Methods and Results - From 1988 to 1990, a total of 73 424 Japanese (30 180 men and 43 244 women), aged 40 to 79 years, without a history of stroke, CHD, or cancer completed a lifestyle questionnaire including perception of mental stress under the Japan Collaborative Cohort Study for Evaluation of Cancer Risk Sponsored by Monbusho (JACC Study). Systematic surveillance was completed until the end of 1997, with a 580 378 person-year follow-up, and the underlying causes of death were determined according to the International Classification of Diseases, 10th revision. For women, there were 316 with total stroke, 113 with CHD, and 643 with total cardiovascular disease (CVD); for men, there were 341, 168, and 778, respectively. Women who reported high stress had a 2-fold higher age-adjusted risk of mortality from total stroke and CHD and 1.5-fold higher risk of total CVD compared with those who reported low stress. Further adjustment for known cardiovascular risk factors and selected psychological variables did not alter the associations materially. The multivariate relative risk for women who perceived high stress versus low stress was 2.24 (95% CI 1.52 to 3.31, P<0.001) for total stroke, 2.28 (95% CI 1.17 to 4.43, P=0.02) for CHD, and 1.64 (95% CI 1.25 to 2.16, P<0.001) for total CVD. For men, these relations were generally weaker but suggestive of myocardial infarction. Conclusions - Perceived mental stress was associated with increased mortality from stroke for women and with CHD for men and women.
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U2 - 10.1161/01.CIR.0000028145.58654.41
DO - 10.1161/01.CIR.0000028145.58654.41
M3 - Article
C2 - 12208798
AN - SCOPUS:0037015229
SN - 0009-7322
VL - 106
SP - 1229
EP - 1236
JO - Circulation
JF - Circulation
IS - 10
ER -