Perceived psychologic stress and colorectal cancer mortality: Findings from the Japan collaborative cohort study

Masayo Kojima, Kenji Wakai, Shinkan Tokudome, Koji Tamakoshi, Hideaki Toyoshima, Yoshiyuki Watanabe, Norihiko Hayakawa, Koji Suzuki, Shuji Hashimoto, Miyuki Kawado, Sadao Suzuki, Yoshinori Ito, Akiko Tamakoshi

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Abstract

Objective: The purpose of this research was to examine the relationship between perceived psychologic stress and colorectal cancer mortality in a prospective large-scale study. Methods: Between the years 1988 and 1990, 32,153 men and 45,854 women aged 40 to 79 years were enrolled. Participants completed a self-administered questionnaire that addressed demographic, lifestyle, and psychosocial characteristics. Subjects were subsequently followed for mortality until the end of 1999. Perceived psychologic stress was assessed using the question "Do you feel stress during your daily life?" The 4 possible responses, ranging from "little or none" (1) to "extreme" (4), were dichotomized as low (1 or 2) or high (3 or 4) stress. Relative risks (RRs) with 95% confidence intervals (CIs) for colon and rectal cancer according to the perceived level of stress were estimated using Cox's proportional hazard model. Results: During the follow-up period (average, 9.6 years), 193 colon cancer deaths (96 men and 97 women) and 127 rectal cancer deaths (88 men and 39 women) were confirmed within the study group. Women who reported high stress had a 1.64-fold higher risk of colon cancer mortality (multivariate-adjusted RR, 1.64; 95% CI, 1.01-2.66) compared with those reporting low stress. There was no significant association between perceived stress and female rectal cancer or male colon and rectal cancer mortality. Conclusions: Perceived psychologic stress was weakly associated with increased mortality from colon cancer in women. No positive or inverse association was found in men. Further studies are needed to confirm our results.

Original languageEnglish
Pages (from-to)72-77
Number of pages6
JournalPsychosomatic Medicine
Volume67
Issue number1
DOIs
Publication statusPublished - 01-01-2005

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Psychological Stress
Colonic Neoplasms
Colorectal Neoplasms
Rectal Neoplasms
Japan
Cohort Studies
Mortality
Confidence Intervals
Proportional Hazards Models
Life Style
Demography
Research

All Science Journal Classification (ASJC) codes

  • Applied Psychology
  • Psychiatry and Mental health

Cite this

Kojima, M., Wakai, K., Tokudome, S., Tamakoshi, K., Toyoshima, H., Watanabe, Y., ... Tamakoshi, A. (2005). Perceived psychologic stress and colorectal cancer mortality: Findings from the Japan collaborative cohort study. Psychosomatic Medicine, 67(1), 72-77. https://doi.org/10.1097/01.psy.0000151742.43774.6d
Kojima, Masayo ; Wakai, Kenji ; Tokudome, Shinkan ; Tamakoshi, Koji ; Toyoshima, Hideaki ; Watanabe, Yoshiyuki ; Hayakawa, Norihiko ; Suzuki, Koji ; Hashimoto, Shuji ; Kawado, Miyuki ; Suzuki, Sadao ; Ito, Yoshinori ; Tamakoshi, Akiko. / Perceived psychologic stress and colorectal cancer mortality : Findings from the Japan collaborative cohort study. In: Psychosomatic Medicine. 2005 ; Vol. 67, No. 1. pp. 72-77.
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Kojima, M, Wakai, K, Tokudome, S, Tamakoshi, K, Toyoshima, H, Watanabe, Y, Hayakawa, N, Suzuki, K, Hashimoto, S, Kawado, M, Suzuki, S, Ito, Y & Tamakoshi, A 2005, 'Perceived psychologic stress and colorectal cancer mortality: Findings from the Japan collaborative cohort study', Psychosomatic Medicine, vol. 67, no. 1, pp. 72-77. https://doi.org/10.1097/01.psy.0000151742.43774.6d

Perceived psychologic stress and colorectal cancer mortality : Findings from the Japan collaborative cohort study. / Kojima, Masayo; Wakai, Kenji; Tokudome, Shinkan; Tamakoshi, Koji; Toyoshima, Hideaki; Watanabe, Yoshiyuki; Hayakawa, Norihiko; Suzuki, Koji; Hashimoto, Shuji; Kawado, Miyuki; Suzuki, Sadao; Ito, Yoshinori; Tamakoshi, Akiko.

In: Psychosomatic Medicine, Vol. 67, No. 1, 01.01.2005, p. 72-77.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Perceived psychologic stress and colorectal cancer mortality

T2 - Findings from the Japan collaborative cohort study

AU - Kojima, Masayo

AU - Wakai, Kenji

AU - Tokudome, Shinkan

AU - Tamakoshi, Koji

AU - Toyoshima, Hideaki

AU - Watanabe, Yoshiyuki

AU - Hayakawa, Norihiko

AU - Suzuki, Koji

AU - Hashimoto, Shuji

AU - Kawado, Miyuki

AU - Suzuki, Sadao

AU - Ito, Yoshinori

AU - Tamakoshi, Akiko

PY - 2005/1/1

Y1 - 2005/1/1

N2 - Objective: The purpose of this research was to examine the relationship between perceived psychologic stress and colorectal cancer mortality in a prospective large-scale study. Methods: Between the years 1988 and 1990, 32,153 men and 45,854 women aged 40 to 79 years were enrolled. Participants completed a self-administered questionnaire that addressed demographic, lifestyle, and psychosocial characteristics. Subjects were subsequently followed for mortality until the end of 1999. Perceived psychologic stress was assessed using the question "Do you feel stress during your daily life?" The 4 possible responses, ranging from "little or none" (1) to "extreme" (4), were dichotomized as low (1 or 2) or high (3 or 4) stress. Relative risks (RRs) with 95% confidence intervals (CIs) for colon and rectal cancer according to the perceived level of stress were estimated using Cox's proportional hazard model. Results: During the follow-up period (average, 9.6 years), 193 colon cancer deaths (96 men and 97 women) and 127 rectal cancer deaths (88 men and 39 women) were confirmed within the study group. Women who reported high stress had a 1.64-fold higher risk of colon cancer mortality (multivariate-adjusted RR, 1.64; 95% CI, 1.01-2.66) compared with those reporting low stress. There was no significant association between perceived stress and female rectal cancer or male colon and rectal cancer mortality. Conclusions: Perceived psychologic stress was weakly associated with increased mortality from colon cancer in women. No positive or inverse association was found in men. Further studies are needed to confirm our results.

AB - Objective: The purpose of this research was to examine the relationship between perceived psychologic stress and colorectal cancer mortality in a prospective large-scale study. Methods: Between the years 1988 and 1990, 32,153 men and 45,854 women aged 40 to 79 years were enrolled. Participants completed a self-administered questionnaire that addressed demographic, lifestyle, and psychosocial characteristics. Subjects were subsequently followed for mortality until the end of 1999. Perceived psychologic stress was assessed using the question "Do you feel stress during your daily life?" The 4 possible responses, ranging from "little or none" (1) to "extreme" (4), were dichotomized as low (1 or 2) or high (3 or 4) stress. Relative risks (RRs) with 95% confidence intervals (CIs) for colon and rectal cancer according to the perceived level of stress were estimated using Cox's proportional hazard model. Results: During the follow-up period (average, 9.6 years), 193 colon cancer deaths (96 men and 97 women) and 127 rectal cancer deaths (88 men and 39 women) were confirmed within the study group. Women who reported high stress had a 1.64-fold higher risk of colon cancer mortality (multivariate-adjusted RR, 1.64; 95% CI, 1.01-2.66) compared with those reporting low stress. There was no significant association between perceived stress and female rectal cancer or male colon and rectal cancer mortality. Conclusions: Perceived psychologic stress was weakly associated with increased mortality from colon cancer in women. No positive or inverse association was found in men. Further studies are needed to confirm our results.

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