TY - JOUR
T1 - Performance comparison between 18 F-FDG PET/CT Plus brain mri and conventional staging plus brain mri in staging of small cell lung carcinoma
AU - Kishida, Yuji
AU - Seki, Shinichiro
AU - Yoshikawa, Takeshi
AU - Itoh, Tomoo
AU - Maniwa, Yoshimasa
AU - Nishimura, Yoshihiro
AU - Ohno, Yoshiharu
N1 - Publisher Copyright:
© 2018 American Roentgen Ray Society.
PY - 2018/7
Y1 - 2018/7
N2 - OBJECTIVE. The purpose of this study was to prospectively compare the capabilities of integrated FDG PET/CT and conventional staging for identification of TNM factors, evaluation of the TNM and Veterans Administration Lung Study Group (VALSG) stages, and selection of patients with stage I small cell lung carcinoma (SCLC). SUBJECTS AND METHODS. Fifty-nine patients (mean age, 69.6 ± 7.8 [SD] years; range, 40–84 years) with pathologically diagnosed SCLC underwent integrated 18 F-FDG PET/CT and conventional staging with enhanced brain MRI. TNM and VALSG stages were evaluated by two different reader groups. Kappa statistics and chi-square test result were determined for evaluations of interobserver agreement of all factors and for each clinical stage for both methods. Diagnostic accuracy of identification of each factor and clinical stage was statistically compared by McNemar test. RESULTS. Interobserver agreements for all factors and each clinical stage were assessed as almost perfect for PET/CT (0.83 ≤ κ ≤ 0.93; p < 0.001) and substantial and almost perfect (0.63 ≤ κ ≤ 0.96; p < 0.001) for conventional staging plus enhanced brain MRI. The diagnostic accuracy of PET/CT for N factor and TNM stage (N, 89.8% [53/59]; TNM stage, 88.1% [52/59]) was significantly higher than that of conventional staging plus enhanced brain MRI (N, 67.8% [40/59], p = 0.0002; TNM stage, 72.9% [43/59], p = 0.004). CONCLUSION. Integrated FDG PET/CT with contrast-enhanced brain MRI is potentially equal to or more effective than conventional staging plus enhanced brain MRI for T, N, and M assessment and TNM and VALSG staging of SCLC.
AB - OBJECTIVE. The purpose of this study was to prospectively compare the capabilities of integrated FDG PET/CT and conventional staging for identification of TNM factors, evaluation of the TNM and Veterans Administration Lung Study Group (VALSG) stages, and selection of patients with stage I small cell lung carcinoma (SCLC). SUBJECTS AND METHODS. Fifty-nine patients (mean age, 69.6 ± 7.8 [SD] years; range, 40–84 years) with pathologically diagnosed SCLC underwent integrated 18 F-FDG PET/CT and conventional staging with enhanced brain MRI. TNM and VALSG stages were evaluated by two different reader groups. Kappa statistics and chi-square test result were determined for evaluations of interobserver agreement of all factors and for each clinical stage for both methods. Diagnostic accuracy of identification of each factor and clinical stage was statistically compared by McNemar test. RESULTS. Interobserver agreements for all factors and each clinical stage were assessed as almost perfect for PET/CT (0.83 ≤ κ ≤ 0.93; p < 0.001) and substantial and almost perfect (0.63 ≤ κ ≤ 0.96; p < 0.001) for conventional staging plus enhanced brain MRI. The diagnostic accuracy of PET/CT for N factor and TNM stage (N, 89.8% [53/59]; TNM stage, 88.1% [52/59]) was significantly higher than that of conventional staging plus enhanced brain MRI (N, 67.8% [40/59], p = 0.0002; TNM stage, 72.9% [43/59], p = 0.004). CONCLUSION. Integrated FDG PET/CT with contrast-enhanced brain MRI is potentially equal to or more effective than conventional staging plus enhanced brain MRI for T, N, and M assessment and TNM and VALSG staging of SCLC.
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U2 - 10.2214/AJR.17.18935
DO - 10.2214/AJR.17.18935
M3 - Article
C2 - 29667886
AN - SCOPUS:85049161729
SN - 0361-803X
VL - 211
SP - 185
EP - 192
JO - American Journal of Roentgenology
JF - American Journal of Roentgenology
IS - 1
ER -