Periomphalitis with delayed umbilical cord separation due to alloimmune neonatal neutropenia

Tomohiro Sameshima; Sota Iwatani; Sachiyo Fukushima; Mariko Taniguchi-Ikeda; Makoto Hashimoto; Kimiko Yurugi; Kazumoto Iijima; Ichiro Morioka

doi:10.7754/clin.lab.2016.160422

Periomphalitis with delayed umbilical cord separation due to alloimmune neonatal neutropenia

Tomohiro Sameshima, Sota Iwatani, Sachiyo Fukushima, Mariko Taniguchi-Ikeda, Makoto Hashimoto, Kimiko Yurugi, Kazumoto Iijima, Ichiro Morioka

Research output: Contribution to journal › Article › peer-review

Abstract

In a preterm infant, small-for-gestational age, neutropenia persisted from the birth, and periomphalitis symptoms appeared at 23 days of age. Upon administration of granulocyte colony-stimulating factor, the neutrophil count increased, and periomphalitis was recovered. At the same time, the umbilical cord separated at 44 days of age. The human neutrophil antigen (HNA) of the infant was la/lb, and antineutrophil antibody for HNA-lb was present in both serums of the mother and the infant at birth, indicating a diagnosis of alloimmune neutropenia. This case demonstrated a definite relationship between the number of neutrophils and the separation of umbilical cord.

Original language	English
Pages (from-to)	2249-2252
Number of pages	4
Journal	Clinical Laboratory
Volume	62
Issue number	11
DOIs	https://doi.org/10.7754/clin.lab.2016.160422
Publication status	Published - 2016
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Biochemistry,Genetics and Molecular Biology

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title = "Periomphalitis with delayed umbilical cord separation due to alloimmune neonatal neutropenia",

abstract = "In a preterm infant, small-for-gestational age, neutropenia persisted from the birth, and periomphalitis symptoms appeared at 23 days of age. Upon administration of granulocyte colony-stimulating factor, the neutrophil count increased, and periomphalitis was recovered. At the same time, the umbilical cord separated at 44 days of age. The human neutrophil antigen (HNA) of the infant was la/lb, and antineutrophil antibody for HNA-lb was present in both serums of the mother and the infant at birth, indicating a diagnosis of alloimmune neutropenia. This case demonstrated a definite relationship between the number of neutrophils and the separation of umbilical cord.",

author = "Tomohiro Sameshima and Sota Iwatani and Sachiyo Fukushima and Mariko Taniguchi-Ikeda and Makoto Hashimoto and Kimiko Yurugi and Kazumoto Iijima and Ichiro Morioka",

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T1 - Periomphalitis with delayed umbilical cord separation due to alloimmune neonatal neutropenia

AU - Sameshima, Tomohiro

AU - Iwatani, Sota

AU - Fukushima, Sachiyo

AU - Taniguchi-Ikeda, Mariko

AU - Hashimoto, Makoto

AU - Yurugi, Kimiko

AU - Iijima, Kazumoto

AU - Morioka, Ichiro

PY - 2016

Y1 - 2016

N2 - In a preterm infant, small-for-gestational age, neutropenia persisted from the birth, and periomphalitis symptoms appeared at 23 days of age. Upon administration of granulocyte colony-stimulating factor, the neutrophil count increased, and periomphalitis was recovered. At the same time, the umbilical cord separated at 44 days of age. The human neutrophil antigen (HNA) of the infant was la/lb, and antineutrophil antibody for HNA-lb was present in both serums of the mother and the infant at birth, indicating a diagnosis of alloimmune neutropenia. This case demonstrated a definite relationship between the number of neutrophils and the separation of umbilical cord.

AB - In a preterm infant, small-for-gestational age, neutropenia persisted from the birth, and periomphalitis symptoms appeared at 23 days of age. Upon administration of granulocyte colony-stimulating factor, the neutrophil count increased, and periomphalitis was recovered. At the same time, the umbilical cord separated at 44 days of age. The human neutrophil antigen (HNA) of the infant was la/lb, and antineutrophil antibody for HNA-lb was present in both serums of the mother and the infant at birth, indicating a diagnosis of alloimmune neutropenia. This case demonstrated a definite relationship between the number of neutrophils and the separation of umbilical cord.

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Periomphalitis with delayed umbilical cord separation due to alloimmune neonatal neutropenia

Abstract

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