TY - JOUR
T1 - Perioperative intensive insulin therapy using an artificial endocrine pancreas with closed-loop glycemic control system
T2 - The effects of no hypoglycemia
AU - Hanazaki, Kazuhiro
AU - Kitagawa, Hiroyuki
AU - Yatabe, Tomoaki
AU - Munekage, Masaya
AU - Dabanaka, Ken
AU - Takezaki, Yuka
AU - Tsukamoto, Yuuki
AU - Asano, Takuji
AU - Kinoshita, Yoshihiko
AU - Namikawa, Tsutomu
PY - 2014/6
Y1 - 2014/6
N2 - BACKGROUND: We examined whether perioperative intensive insulin therapy (IIT) using an artificial pancreas (AP) with a closed-loop glycemic control system can be used to prevent hypoglycemia in surgical patients. METHODS: Between 2006 and 2012, perioperative glycemic control using an AP was performed in 427 patients undergoing general surgery. A total of 305 patients undergoing IIT using an AP in the target blood glucose range of 80 to 110 mg/dL were enrolled in the study. Data were collected prospectively and were reviewed or analyzed retrospectively. RESULTS: No patients had hypoglycemia. Perioperative mean blood glucose level and achievement rates in target blood glucose range of 80 to 110 mg/dL were 100.5 ± 11.9 mg/dL and 88.1% ± 16.0%, respectively. For the 3 primary operative methods, including hepatic, pancreatic, and esophageal resections, there were no significant differences in glycemic control stability between the types of surgery. CONCLUSION: Perioperative IIT using an AP with a closed-loop glycemic control system can be used to prevent hypoglycemia and maintain stable glycemic control with less variability of blood glucose concentration.
AB - BACKGROUND: We examined whether perioperative intensive insulin therapy (IIT) using an artificial pancreas (AP) with a closed-loop glycemic control system can be used to prevent hypoglycemia in surgical patients. METHODS: Between 2006 and 2012, perioperative glycemic control using an AP was performed in 427 patients undergoing general surgery. A total of 305 patients undergoing IIT using an AP in the target blood glucose range of 80 to 110 mg/dL were enrolled in the study. Data were collected prospectively and were reviewed or analyzed retrospectively. RESULTS: No patients had hypoglycemia. Perioperative mean blood glucose level and achievement rates in target blood glucose range of 80 to 110 mg/dL were 100.5 ± 11.9 mg/dL and 88.1% ± 16.0%, respectively. For the 3 primary operative methods, including hepatic, pancreatic, and esophageal resections, there were no significant differences in glycemic control stability between the types of surgery. CONCLUSION: Perioperative IIT using an AP with a closed-loop glycemic control system can be used to prevent hypoglycemia and maintain stable glycemic control with less variability of blood glucose concentration.
KW - Artificial pancreas
KW - Closed-loop glycemic control system
KW - Hypoglycemia
KW - Perioperative intensive insulin therapy
KW - Stable glycemic control
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U2 - 10.1016/j.amjsurg.2013.07.048
DO - 10.1016/j.amjsurg.2013.07.048
M3 - Article
C2 - 24480234
AN - SCOPUS:84901845302
SN - 0002-9610
VL - 207
SP - 935
EP - 941
JO - American Journal of Surgery
JF - American Journal of Surgery
IS - 6
ER -