Peripheral deletion of γδ T cells in haemodialyis patients

Yoshihiro Matsumoto, Toru Shinzato, Ichiro Takai, Akeyo Nishimoto, Shigeru Nakai, Tetsu Sakai, Izumi Amano, Kenji Maeda

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Many patients with end-stage renal disease have altered host defenses against infectious agents. We have demonstrated that T cells, which play an important role in the immunological response, may undergo apoptosis by the Fas system in uraemia. To elucidate whether γδ T cells, which function as a first defense against intracellular pathogens, are altered in number or characteristics in dialysis patients, surface expressions of TCR, LFA-1 and Fas antigen on peripheral T cells were examined by immunofluorescence analysis. We demonstrated that the proportions of peripheral γδ T cells are altered significantly in haemodialysis (HD) patients. Interestingly, there were marked differences in the levels of expression of LFA-1 and Fas antigen between the two types of T cells. Moreover, both the expression of LFA-1 and that of Fas antigen were enhanced significantly in HD patients compared with normal controls. These results suggest that circulating γδ T cells may be susceptible to activation-induced cell death in comparison with αβ T cells in uraemic environments.

Original languageEnglish
Pages (from-to)2861-2866
Number of pages6
JournalNephrology Dialysis Transplantation
Volume13
Issue number11
DOIs
Publication statusPublished - 11-1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Nephrology
  • Transplantation

Fingerprint Dive into the research topics of 'Peripheral deletion of γδ T cells in haemodialyis patients'. Together they form a unique fingerprint.

Cite this