TY - JOUR
T1 - Peripheral vein infusions of amino acids facilitate recovery after esophagectomy for esophageal cancer
T2 - Retrospective cohort analysis
AU - Konosu, Masafumi
AU - Iwaya, Takeshi
AU - Kimura, Yusuke
AU - Akiyama, Yuji
AU - Shioi, Yoshihiro
AU - Endo, Fumitaka
AU - Nitta, Hiroyuki
AU - Otsuka, Koki
AU - Koeda, Keisuke
AU - Sasaki, Akira
N1 - Publisher Copyright:
© 2017 The Author(s)
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Background To investigate the efficacy of amino acid administration via peripheral veins in addition to conventional enteral feeding following esophagectomy. Materials and methods Retrospective analysis of data pertaining to 33 patients with esophageal cancer who underwent radical esophagectomy and satisfied the required nutrition control. Patients were divided into the amino acid group (n = 17) and control group (n = 16). Primary outcomes were albumin (Alb) and prealbumin (PreAlb) levels, urinary 3-methylhistidine/creatinine (3-MeHis/Cre) ratios, nitrogen balance, and weight; postoperative complications were noted as secondary outcomes. Results Alb levels were significantly higher in the amino acid group on postoperative day (POD)-14 (3.4 ± 0.3 vs. 3.1 ± 0.4 mg/dL in the control group, p = 0.018) and at 1 month after surgery (3.8 ± 0.4 vs. 3.5 ± 0.3 mg/dL, p = 0.045). No significant differences were observed in PreAlb and urinary 3-MeHis/Cre rates between the treatment groups. Body weights at 3 months postoperatively were decreased by 6% and 3% in the control and amino acid groups, respectively. Conclusion Peripheral venous administration of amino acids soon after surgical stress is an effective method for nutritional control.
AB - Background To investigate the efficacy of amino acid administration via peripheral veins in addition to conventional enteral feeding following esophagectomy. Materials and methods Retrospective analysis of data pertaining to 33 patients with esophageal cancer who underwent radical esophagectomy and satisfied the required nutrition control. Patients were divided into the amino acid group (n = 17) and control group (n = 16). Primary outcomes were albumin (Alb) and prealbumin (PreAlb) levels, urinary 3-methylhistidine/creatinine (3-MeHis/Cre) ratios, nitrogen balance, and weight; postoperative complications were noted as secondary outcomes. Results Alb levels were significantly higher in the amino acid group on postoperative day (POD)-14 (3.4 ± 0.3 vs. 3.1 ± 0.4 mg/dL in the control group, p = 0.018) and at 1 month after surgery (3.8 ± 0.4 vs. 3.5 ± 0.3 mg/dL, p = 0.045). No significant differences were observed in PreAlb and urinary 3-MeHis/Cre rates between the treatment groups. Body weights at 3 months postoperatively were decreased by 6% and 3% in the control and amino acid groups, respectively. Conclusion Peripheral venous administration of amino acids soon after surgical stress is an effective method for nutritional control.
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U2 - 10.1016/j.amsu.2017.01.016
DO - 10.1016/j.amsu.2017.01.016
M3 - Article
AN - SCOPUS:85009863182
SN - 2049-0801
VL - 14
SP - 29
EP - 35
JO - Annals of Medicine and Surgery
JF - Annals of Medicine and Surgery
ER -