Peripherally administered baclofen reduced food intake and body weight in db/db as well as diet-induced obese mice

Ikuko Sato, Hiroshi Arima, Noriyuki Ozaki, Nobuaki Ozaki, Minemori Watanabe, Motomitsu Goto, Hiroshi Shimizu, Masayuki Hayashi, Ryouichi Banno, Hiroshi Nagasaki, Yutaka Oiso

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Peripheral administration of baclofen significantly reduced food intake and body weight increase in both diabetic (db/db) and diet-induced obese mice for 5 weeks, whereas it had no significant effects on energy balance in their lean control mice. Despite the decreased body weight, neuropeptide Y expression in the arcuate nucleus was significantly decreased, whereas pro-opiomelanocortin expression was significantly increased by baclofen treatment. These data demonstrate that the inhibitory effects of baclofen on body weight in the obese mice were mediated via the arcuate nucleus at least partially, and suggest that GABAB agonists could be a new therapeutic reagent for obesity.

Original languageEnglish
Pages (from-to)4857-4864
Number of pages8
JournalFEBS Letters
Volume581
Issue number25
DOIs
Publication statusPublished - 16-10-2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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