Peripherally administered baclofen reduced food intake and body weight in db/db as well as diet-induced obese mice

Ikuko Sato; Hiroshi Arima; Noriyuki Ozaki; Nobuaki Ozaki; Minemori Watanabe; Motomitsu Goto; Hiroshi Shimizu; Masayuki Hayashi; Ryouichi Banno; Hiroshi Nagasaki; Yutaka Oiso

doi:10.1016/j.febslet.2007.09.011

Peripherally administered baclofen reduced food intake and body weight in db/db as well as diet-induced obese mice

Ikuko Sato
, Hiroshi Arima
, Noriyuki Ozaki
, Nobuaki Ozaki
, Minemori Watanabe
, Motomitsu Goto
, Hiroshi Shimizu
, Masayuki Hayashi
, Ryouichi Banno
, Hiroshi Nagasaki
, Yutaka Oiso

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Peripheral administration of baclofen significantly reduced food intake and body weight increase in both diabetic (db/db) and diet-induced obese mice for 5 weeks, whereas it had no significant effects on energy balance in their lean control mice. Despite the decreased body weight, neuropeptide Y expression in the arcuate nucleus was significantly decreased, whereas pro-opiomelanocortin expression was significantly increased by baclofen treatment. These data demonstrate that the inhibitory effects of baclofen on body weight in the obese mice were mediated via the arcuate nucleus at least partially, and suggest that GABA_B agonists could be a new therapeutic reagent for obesity.

Original language	English
Pages (from-to)	4857-4864
Number of pages	8
Journal	FEBS Letters
Volume	581
Issue number	25
DOIs	https://doi.org/10.1016/j.febslet.2007.09.011
Publication status	Published - 16-10-2007
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

Access to Document

10.1016/j.febslet.2007.09.011

Cite this

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title = "Peripherally administered baclofen reduced food intake and body weight in db/db as well as diet-induced obese mice",

abstract = "Peripheral administration of baclofen significantly reduced food intake and body weight increase in both diabetic (db/db) and diet-induced obese mice for 5 weeks, whereas it had no significant effects on energy balance in their lean control mice. Despite the decreased body weight, neuropeptide Y expression in the arcuate nucleus was significantly decreased, whereas pro-opiomelanocortin expression was significantly increased by baclofen treatment. These data demonstrate that the inhibitory effects of baclofen on body weight in the obese mice were mediated via the arcuate nucleus at least partially, and suggest that GABAB agonists could be a new therapeutic reagent for obesity.",

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author = "Ikuko Sato and Hiroshi Arima and Noriyuki Ozaki and Nobuaki Ozaki and Minemori Watanabe and Motomitsu Goto and Hiroshi Shimizu and Masayuki Hayashi and Ryouichi Banno and Hiroshi Nagasaki and Yutaka Oiso",

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doi = "10.1016/j.febslet.2007.09.011",

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T1 - Peripherally administered baclofen reduced food intake and body weight in db/db as well as diet-induced obese mice

AU - Sato, Ikuko

AU - Arima, Hiroshi

AU - Ozaki, Noriyuki

AU - Ozaki, Nobuaki

AU - Watanabe, Minemori

AU - Goto, Motomitsu

AU - Shimizu, Hiroshi

AU - Hayashi, Masayuki

AU - Banno, Ryouichi

AU - Nagasaki, Hiroshi

AU - Oiso, Yutaka

PY - 2007/10/16

Y1 - 2007/10/16

N2 - Peripheral administration of baclofen significantly reduced food intake and body weight increase in both diabetic (db/db) and diet-induced obese mice for 5 weeks, whereas it had no significant effects on energy balance in their lean control mice. Despite the decreased body weight, neuropeptide Y expression in the arcuate nucleus was significantly decreased, whereas pro-opiomelanocortin expression was significantly increased by baclofen treatment. These data demonstrate that the inhibitory effects of baclofen on body weight in the obese mice were mediated via the arcuate nucleus at least partially, and suggest that GABAB agonists could be a new therapeutic reagent for obesity.

AB - Peripheral administration of baclofen significantly reduced food intake and body weight increase in both diabetic (db/db) and diet-induced obese mice for 5 weeks, whereas it had no significant effects on energy balance in their lean control mice. Despite the decreased body weight, neuropeptide Y expression in the arcuate nucleus was significantly decreased, whereas pro-opiomelanocortin expression was significantly increased by baclofen treatment. These data demonstrate that the inhibitory effects of baclofen on body weight in the obese mice were mediated via the arcuate nucleus at least partially, and suggest that GABAB agonists could be a new therapeutic reagent for obesity.

KW - GABA agonists

KW - Hypothalamus

KW - Neuropeptide Y

KW - Obesity

KW - Pro-opiomelanocortin

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UR - https://www.scopus.com/pages/publications/34948892964#tab=citedBy

U2 - 10.1016/j.febslet.2007.09.011

DO - 10.1016/j.febslet.2007.09.011

M3 - Article

C2 - 17888909

AN - SCOPUS:34948892964

SN - 0014-5793

VL - 581

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JF - FEBS Letters

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ER -

Peripherally administered baclofen reduced food intake and body weight in db/db as well as diet-induced obese mice

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

Access to Document

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