Peritonitis is still an important factor for withdrawal from peritoneal dialysis therapy in the Tokai area of Japan

Masashi Mizuno, Yasuhiko Ito, Akio Tanaka, Yasuhiro Suzuki, Hideki Hiramatsu, Midoriko Watanabe, Yoshikazu Tsuruta, Teppei Matsuoka, Isao Ito, Hiroshi Tamai, Hirotake Kasuga, Hideaki Shimizu, Hisashi Kurata, Daijo Inaguma, Takeyuki Hiramatsu, Masanobu Horie, Tomohiko Naruse, Shoichi Maruyama, Enyu Imai, Yukio YuzawaSeiichi Matsuo

Research output: Contribution to journalArticlepeer-review

70 Citations (Scopus)


Background: In Japan, the population of patients on peritoneal dialysis (PD) is <4% of the total number of patients with end-stage renal disease. Few systemic analyses have examined why the number of PD patients has not increased in Japan. We organized a registry to analyze PD patients and retrospectively investigated 561 PD patients (about 5% of all Japanese PD patients) from 13 hospitals in the Tokai area for 3 years from 2005. Methods: We investigated background, physical status, laboratory data, status of PD therapy, and the occurrence of PD-related complications, and analyzed reasons for withdrawal from PD. Results: Nutrition did not change significantly during our observation. Urinary volume showed continued decreases after the introduction period. In contrast, PD fluid demand and ultrafiltration volume were significantly increased. For calcium metabolism, multiple phosphate binders were required after the second year of PD therapy. Early drop-out within 3 years after starting PD therapy comprised 50.9% of total withdrawals, with PD-related peritonitis as the most common reason, mainly caused by Gram-positive organisms. Incidence of peritonitis was 42.8 months/patient. Culture-negative results were obtained for 32% of peritonitis cultures. Diabetes affects the prognosis of PD therapy, but not the incidence of peritonitis. Conclusion: We examined clinical status over 3 years in the Tokai area. The results suggest that the incidence of peritonitis needs to be decreased to prevent early withdrawal of PD patients. Education systems to decrease the incidence of peritonitis and techniques to decrease culture-negative results might be important for improving the prognosis of peritonitis.

Original languageEnglish
Pages (from-to)727-737
Number of pages11
JournalClinical and Experimental Nephrology
Issue number5
Publication statusPublished - 10-2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Physiology
  • Nephrology
  • Physiology (medical)


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