Peritonitis is still an important factor for withdrawal from peritoneal dialysis therapy in the Tokai area of Japan

Masashi Mizuno, Yasuhiko Ito, Akio Tanaka, Yasuhiro Suzuki, Hideki Hiramatsu, Midoriko Watanabe, Yoshikazu Tsuruta, Teppei Matsuoka, Isao Ito, Hiroshi Tamai, Hirotake Kasuga, Hideaki Shimizu, Hisashi Kurata, Daijo Inaguma, Takeyuki Hiramatsu, Masanobu Horie, Tomohiko Naruse, Shoichi Maruyama, Enyu Imai, Yukio Yuzawa & 1 others Seiichi Matsuo

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Abstract

Background: In Japan, the population of patients on peritoneal dialysis (PD) is <4% of the total number of patients with end-stage renal disease. Few systemic analyses have examined why the number of PD patients has not increased in Japan. We organized a registry to analyze PD patients and retrospectively investigated 561 PD patients (about 5% of all Japanese PD patients) from 13 hospitals in the Tokai area for 3 years from 2005. Methods: We investigated background, physical status, laboratory data, status of PD therapy, and the occurrence of PD-related complications, and analyzed reasons for withdrawal from PD. Results: Nutrition did not change significantly during our observation. Urinary volume showed continued decreases after the introduction period. In contrast, PD fluid demand and ultrafiltration volume were significantly increased. For calcium metabolism, multiple phosphate binders were required after the second year of PD therapy. Early drop-out within 3 years after starting PD therapy comprised 50.9% of total withdrawals, with PD-related peritonitis as the most common reason, mainly caused by Gram-positive organisms. Incidence of peritonitis was 42.8 months/patient. Culture-negative results were obtained for 32% of peritonitis cultures. Diabetes affects the prognosis of PD therapy, but not the incidence of peritonitis. Conclusion: We examined clinical status over 3 years in the Tokai area. The results suggest that the incidence of peritonitis needs to be decreased to prevent early withdrawal of PD patients. Education systems to decrease the incidence of peritonitis and techniques to decrease culture-negative results might be important for improving the prognosis of peritonitis.

Original languageEnglish
Pages (from-to)727-737
Number of pages11
JournalClinical and Experimental Nephrology
Volume15
Issue number5
DOIs
Publication statusPublished - 01-10-2011

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Peritoneal Dialysis
Peritonitis
Japan
Therapeutics
Incidence
Ascitic Fluid
Ultrafiltration
Chronic Kidney Failure
Registries

All Science Journal Classification (ASJC) codes

  • Physiology
  • Nephrology
  • Physiology (medical)

Cite this

Mizuno, Masashi ; Ito, Yasuhiko ; Tanaka, Akio ; Suzuki, Yasuhiro ; Hiramatsu, Hideki ; Watanabe, Midoriko ; Tsuruta, Yoshikazu ; Matsuoka, Teppei ; Ito, Isao ; Tamai, Hiroshi ; Kasuga, Hirotake ; Shimizu, Hideaki ; Kurata, Hisashi ; Inaguma, Daijo ; Hiramatsu, Takeyuki ; Horie, Masanobu ; Naruse, Tomohiko ; Maruyama, Shoichi ; Imai, Enyu ; Yuzawa, Yukio ; Matsuo, Seiichi. / Peritonitis is still an important factor for withdrawal from peritoneal dialysis therapy in the Tokai area of Japan. In: Clinical and Experimental Nephrology. 2011 ; Vol. 15, No. 5. pp. 727-737.
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title = "Peritonitis is still an important factor for withdrawal from peritoneal dialysis therapy in the Tokai area of Japan",
abstract = "Background: In Japan, the population of patients on peritoneal dialysis (PD) is <4{\%} of the total number of patients with end-stage renal disease. Few systemic analyses have examined why the number of PD patients has not increased in Japan. We organized a registry to analyze PD patients and retrospectively investigated 561 PD patients (about 5{\%} of all Japanese PD patients) from 13 hospitals in the Tokai area for 3 years from 2005. Methods: We investigated background, physical status, laboratory data, status of PD therapy, and the occurrence of PD-related complications, and analyzed reasons for withdrawal from PD. Results: Nutrition did not change significantly during our observation. Urinary volume showed continued decreases after the introduction period. In contrast, PD fluid demand and ultrafiltration volume were significantly increased. For calcium metabolism, multiple phosphate binders were required after the second year of PD therapy. Early drop-out within 3 years after starting PD therapy comprised 50.9{\%} of total withdrawals, with PD-related peritonitis as the most common reason, mainly caused by Gram-positive organisms. Incidence of peritonitis was 42.8 months/patient. Culture-negative results were obtained for 32{\%} of peritonitis cultures. Diabetes affects the prognosis of PD therapy, but not the incidence of peritonitis. Conclusion: We examined clinical status over 3 years in the Tokai area. The results suggest that the incidence of peritonitis needs to be decreased to prevent early withdrawal of PD patients. Education systems to decrease the incidence of peritonitis and techniques to decrease culture-negative results might be important for improving the prognosis of peritonitis.",
author = "Masashi Mizuno and Yasuhiko Ito and Akio Tanaka and Yasuhiro Suzuki and Hideki Hiramatsu and Midoriko Watanabe and Yoshikazu Tsuruta and Teppei Matsuoka and Isao Ito and Hiroshi Tamai and Hirotake Kasuga and Hideaki Shimizu and Hisashi Kurata and Daijo Inaguma and Takeyuki Hiramatsu and Masanobu Horie and Tomohiko Naruse and Shoichi Maruyama and Enyu Imai and Yukio Yuzawa and Seiichi Matsuo",
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Mizuno, M, Ito, Y, Tanaka, A, Suzuki, Y, Hiramatsu, H, Watanabe, M, Tsuruta, Y, Matsuoka, T, Ito, I, Tamai, H, Kasuga, H, Shimizu, H, Kurata, H, Inaguma, D, Hiramatsu, T, Horie, M, Naruse, T, Maruyama, S, Imai, E, Yuzawa, Y & Matsuo, S 2011, 'Peritonitis is still an important factor for withdrawal from peritoneal dialysis therapy in the Tokai area of Japan', Clinical and Experimental Nephrology, vol. 15, no. 5, pp. 727-737. https://doi.org/10.1007/s10157-011-0471-8

Peritonitis is still an important factor for withdrawal from peritoneal dialysis therapy in the Tokai area of Japan. / Mizuno, Masashi; Ito, Yasuhiko; Tanaka, Akio; Suzuki, Yasuhiro; Hiramatsu, Hideki; Watanabe, Midoriko; Tsuruta, Yoshikazu; Matsuoka, Teppei; Ito, Isao; Tamai, Hiroshi; Kasuga, Hirotake; Shimizu, Hideaki; Kurata, Hisashi; Inaguma, Daijo; Hiramatsu, Takeyuki; Horie, Masanobu; Naruse, Tomohiko; Maruyama, Shoichi; Imai, Enyu; Yuzawa, Yukio; Matsuo, Seiichi.

In: Clinical and Experimental Nephrology, Vol. 15, No. 5, 01.10.2011, p. 727-737.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Peritonitis is still an important factor for withdrawal from peritoneal dialysis therapy in the Tokai area of Japan

AU - Mizuno, Masashi

AU - Ito, Yasuhiko

AU - Tanaka, Akio

AU - Suzuki, Yasuhiro

AU - Hiramatsu, Hideki

AU - Watanabe, Midoriko

AU - Tsuruta, Yoshikazu

AU - Matsuoka, Teppei

AU - Ito, Isao

AU - Tamai, Hiroshi

AU - Kasuga, Hirotake

AU - Shimizu, Hideaki

AU - Kurata, Hisashi

AU - Inaguma, Daijo

AU - Hiramatsu, Takeyuki

AU - Horie, Masanobu

AU - Naruse, Tomohiko

AU - Maruyama, Shoichi

AU - Imai, Enyu

AU - Yuzawa, Yukio

AU - Matsuo, Seiichi

PY - 2011/10/1

Y1 - 2011/10/1

N2 - Background: In Japan, the population of patients on peritoneal dialysis (PD) is <4% of the total number of patients with end-stage renal disease. Few systemic analyses have examined why the number of PD patients has not increased in Japan. We organized a registry to analyze PD patients and retrospectively investigated 561 PD patients (about 5% of all Japanese PD patients) from 13 hospitals in the Tokai area for 3 years from 2005. Methods: We investigated background, physical status, laboratory data, status of PD therapy, and the occurrence of PD-related complications, and analyzed reasons for withdrawal from PD. Results: Nutrition did not change significantly during our observation. Urinary volume showed continued decreases after the introduction period. In contrast, PD fluid demand and ultrafiltration volume were significantly increased. For calcium metabolism, multiple phosphate binders were required after the second year of PD therapy. Early drop-out within 3 years after starting PD therapy comprised 50.9% of total withdrawals, with PD-related peritonitis as the most common reason, mainly caused by Gram-positive organisms. Incidence of peritonitis was 42.8 months/patient. Culture-negative results were obtained for 32% of peritonitis cultures. Diabetes affects the prognosis of PD therapy, but not the incidence of peritonitis. Conclusion: We examined clinical status over 3 years in the Tokai area. The results suggest that the incidence of peritonitis needs to be decreased to prevent early withdrawal of PD patients. Education systems to decrease the incidence of peritonitis and techniques to decrease culture-negative results might be important for improving the prognosis of peritonitis.

AB - Background: In Japan, the population of patients on peritoneal dialysis (PD) is <4% of the total number of patients with end-stage renal disease. Few systemic analyses have examined why the number of PD patients has not increased in Japan. We organized a registry to analyze PD patients and retrospectively investigated 561 PD patients (about 5% of all Japanese PD patients) from 13 hospitals in the Tokai area for 3 years from 2005. Methods: We investigated background, physical status, laboratory data, status of PD therapy, and the occurrence of PD-related complications, and analyzed reasons for withdrawal from PD. Results: Nutrition did not change significantly during our observation. Urinary volume showed continued decreases after the introduction period. In contrast, PD fluid demand and ultrafiltration volume were significantly increased. For calcium metabolism, multiple phosphate binders were required after the second year of PD therapy. Early drop-out within 3 years after starting PD therapy comprised 50.9% of total withdrawals, with PD-related peritonitis as the most common reason, mainly caused by Gram-positive organisms. Incidence of peritonitis was 42.8 months/patient. Culture-negative results were obtained for 32% of peritonitis cultures. Diabetes affects the prognosis of PD therapy, but not the incidence of peritonitis. Conclusion: We examined clinical status over 3 years in the Tokai area. The results suggest that the incidence of peritonitis needs to be decreased to prevent early withdrawal of PD patients. Education systems to decrease the incidence of peritonitis and techniques to decrease culture-negative results might be important for improving the prognosis of peritonitis.

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U2 - 10.1007/s10157-011-0471-8

DO - 10.1007/s10157-011-0471-8

M3 - Article

VL - 15

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EP - 737

JO - Clinical and Experimental Nephrology

JF - Clinical and Experimental Nephrology

SN - 1342-1751

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