Persistence of protective immunity after postexposure prophylaxis of varicella with oral aciclovir in the family setting

Tetsushi Yoshikawa, Sadao Suga, Toru Kozawa, Shinji Kawaguchi, Yoshizo Asano

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The persistence of protective immunity after postexposure prophylaxis against varicella using oral aciclovir was evaluated in the family setting. Sixty one of 78 recipients of oral aciclovir were assessed by questionnaire, and 13 of 61 were evaluated for serum antibody to varicella zoster virus (VZV) using the fluorescent anti body to membrane antigen method. The observation period ranged from 33 to 50 months. None of those (n = 44) who had initially seroconverted to VZV after aciclovir prophylaxis developed breakthrough varicella. All 13 who had serology repeated still had titres ≤ 4. Antibody titres in those who had histories of re-exposure to the virus were significantly higher than in those who had not (p<0.01).

Original languageEnglish
Pages (from-to)61-63
Number of pages3
JournalArchives of Disease in Childhood
Volume78
Issue number1
DOIs
Publication statusPublished - 01-01-1998

Fingerprint

Acyclovir
Chickenpox
Immunity
Human Herpesvirus 3
Antibodies
Serology
Observation
Viruses
Antigens
Membranes
Serum

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

@article{5ee8714ca03f433b9120c2947b09ed9d,
title = "Persistence of protective immunity after postexposure prophylaxis of varicella with oral aciclovir in the family setting",
abstract = "The persistence of protective immunity after postexposure prophylaxis against varicella using oral aciclovir was evaluated in the family setting. Sixty one of 78 recipients of oral aciclovir were assessed by questionnaire, and 13 of 61 were evaluated for serum antibody to varicella zoster virus (VZV) using the fluorescent anti body to membrane antigen method. The observation period ranged from 33 to 50 months. None of those (n = 44) who had initially seroconverted to VZV after aciclovir prophylaxis developed breakthrough varicella. All 13 who had serology repeated still had titres ≤ 4. Antibody titres in those who had histories of re-exposure to the virus were significantly higher than in those who had not (p<0.01).",
author = "Tetsushi Yoshikawa and Sadao Suga and Toru Kozawa and Shinji Kawaguchi and Yoshizo Asano",
year = "1998",
month = "1",
day = "1",
doi = "10.1136/adc.78.1.61",
language = "English",
volume = "78",
pages = "61--63",
journal = "Archives of Disease in Childhood",
issn = "0003-9888",
publisher = "BMJ Publishing Group",
number = "1",

}

Persistence of protective immunity after postexposure prophylaxis of varicella with oral aciclovir in the family setting. / Yoshikawa, Tetsushi; Suga, Sadao; Kozawa, Toru; Kawaguchi, Shinji; Asano, Yoshizo.

In: Archives of Disease in Childhood, Vol. 78, No. 1, 01.01.1998, p. 61-63.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Persistence of protective immunity after postexposure prophylaxis of varicella with oral aciclovir in the family setting

AU - Yoshikawa, Tetsushi

AU - Suga, Sadao

AU - Kozawa, Toru

AU - Kawaguchi, Shinji

AU - Asano, Yoshizo

PY - 1998/1/1

Y1 - 1998/1/1

N2 - The persistence of protective immunity after postexposure prophylaxis against varicella using oral aciclovir was evaluated in the family setting. Sixty one of 78 recipients of oral aciclovir were assessed by questionnaire, and 13 of 61 were evaluated for serum antibody to varicella zoster virus (VZV) using the fluorescent anti body to membrane antigen method. The observation period ranged from 33 to 50 months. None of those (n = 44) who had initially seroconverted to VZV after aciclovir prophylaxis developed breakthrough varicella. All 13 who had serology repeated still had titres ≤ 4. Antibody titres in those who had histories of re-exposure to the virus were significantly higher than in those who had not (p<0.01).

AB - The persistence of protective immunity after postexposure prophylaxis against varicella using oral aciclovir was evaluated in the family setting. Sixty one of 78 recipients of oral aciclovir were assessed by questionnaire, and 13 of 61 were evaluated for serum antibody to varicella zoster virus (VZV) using the fluorescent anti body to membrane antigen method. The observation period ranged from 33 to 50 months. None of those (n = 44) who had initially seroconverted to VZV after aciclovir prophylaxis developed breakthrough varicella. All 13 who had serology repeated still had titres ≤ 4. Antibody titres in those who had histories of re-exposure to the virus were significantly higher than in those who had not (p<0.01).

UR - http://www.scopus.com/inward/record.url?scp=0031967746&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031967746&partnerID=8YFLogxK

U2 - 10.1136/adc.78.1.61

DO - 10.1136/adc.78.1.61

M3 - Article

C2 - 9534679

AN - SCOPUS:0031967746

VL - 78

SP - 61

EP - 63

JO - Archives of Disease in Childhood

JF - Archives of Disease in Childhood

SN - 0003-9888

IS - 1

ER -