Perspective of strategic plasma therapy for prognostic improvement of patients with ovarian cancer

Hiroaki Kajiyama, Fumi Utsumi, Kae Nakamura, Hiromasa Tanaka, Masaru Hori, Fumitaka Kikkawa

Research output: Contribution to journalConference articlepeer-review

Abstract

Epithelial ovarian carcinoma (EOC) is the leading cause of cancer-related death in women in Western countries. Once patients experience recurrence, complete cure is almost impossible. We elucidated the effect of nonequilibrium atmospheric pressure plasma on the growth of EOC, particularly in plasma-activated medium (PAM). Furthermore, we examined the role of reactive oxygen species (ROS) or their scavengers in chronic antineoplastic-resistant EOC cells. As a result, we showed PAM induced the antitumor effect of EOC cells in vitro and in vivo, even in chemoresistant cells. To apply the plasma treatment for advanced or recurrent EOC, we suggest adopting indirect plasma therapy instead of direct plasma considering intraperitoneal administration in the future. However, there are several problems under investigation, including intracellular mechanism of antitumor effect by PAM and adverse event in vivo.

Original languageEnglish
JournalMaterials Research Society Symposium Proceedings
Volume1598
DOIs
Publication statusPublished - 2013
Externally publishedYes
Event2013 JSAP-MRS Joint Symposia - Kyoto, Japan
Duration: 16-09-201320-09-2013

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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