TY - JOUR
T1 - Pharmacodynamics and pharmacokinetics of remifentanil
T2 - Overview and comparison with other opioids
AU - Kato, Masato
AU - Satoh, Daizoh
AU - Okada, Yoshifumi
AU - Sugiyama, Kimitoshi
AU - Toda, Noriko
AU - Kurosawa, Shin
PY - 2007/11
Y1 - 2007/11
N2 - In this review, the authors tried to summarize the characteristics and main differences of remifentanil with other opioids, and to overview its pharmacodynamics and pharmacokinetics. Clearance and volume of distribution of remifentnail are extremely different from other conventional opioids. In addition, the context-sensitive half time of remifentanil is almost stable (about 3 minutes) even if the continuous infusion of remifentanil lasts for longer than 10 hours. As remifentanil is metabolized by a non-specific esterase, excretion of remifentnil is predictable in basically all patients undergoing general anesthesia and surgery. Therefore, remifentanil is considered to be an optimal opioid as an analgesic combined either with inhalational anesthetics or intravenous hypnotics in balanced general anesthesia.
AB - In this review, the authors tried to summarize the characteristics and main differences of remifentanil with other opioids, and to overview its pharmacodynamics and pharmacokinetics. Clearance and volume of distribution of remifentnail are extremely different from other conventional opioids. In addition, the context-sensitive half time of remifentanil is almost stable (about 3 minutes) even if the continuous infusion of remifentanil lasts for longer than 10 hours. As remifentanil is metabolized by a non-specific esterase, excretion of remifentnil is predictable in basically all patients undergoing general anesthesia and surgery. Therefore, remifentanil is considered to be an optimal opioid as an analgesic combined either with inhalational anesthetics or intravenous hypnotics in balanced general anesthesia.
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M3 - Review article
C2 - 18027596
AN - SCOPUS:36248990289
SN - 0021-4892
VL - 56
SP - 1281
EP - 1286
JO - Japanese Journal of Anesthesiology
JF - Japanese Journal of Anesthesiology
IS - 11
ER -