Pharmacokinetics and clinical evaluation of aztreonam in pediatric surgery

Yura Jiro; Suzuki Tatsuya; Hashimoto Takashi; Nakamura Tsukasa; Shimizu Yasunobu; Minami Munehito; Kamiya Yasuhiro; Narita Hiroshi; Tsuruga Nobuatsu

doi:10.11553/antibiotics1968b.43.534

Pharmacokinetics and clinical evaluation of aztreonam in pediatric surgery

Yura Jiro, Suzuki Tatsuya, Hashimoto Takashi, Nakamura Tsukasa, Shimizu Yasunobu, Minami Munehito, Kamiya Yasuhiro, Narita Hiroshi, Tsuruga Nobuatsu

Pediatric Surgery

Research output: Contribution to journal › Article › peer-review

Abstract

Pharmacokinetic and clinical studies on aztreonam (AZT) in pediatric surgery were performed and results obtained are summarized below.1. Plasma and urinary levels of AZT were measured in 6 neonate patients following drip-infusion for 1 hour of AZT (dose of AZT: 20mg/kg). Plasma levels reached their peak (42.3-50.4 /ig/ml) at the end of infusion or in 1 hour thereafter except in case 2. In case 2, plasma level reached its peak (36.6 jug/ml) at 2 hours after the end of infusion. Plasma levels of AZT decreased rapidly after reaching their peaks, and plasma half-lives (T 1/2) were 1.852-.84 hours. Urinary recovery rates were 15.7-65 3%.

Original language	English
Pages (from-to)	534-542
Number of pages	9
Journal	the japanese journal of antibiotics
Volume	43
Issue number	3
DOIs	https://doi.org/10.11553/antibiotics1968b.43.534
Publication status	Published - 1990

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Pharmacology (medical)
Infectious Diseases

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@article{d61abc4ac2e6489a90a3cc417c6c631b,

title = "Pharmacokinetics and clinical evaluation of aztreonam in pediatric surgery",

abstract = "Pharmacokinetic and clinical studies on aztreonam (AZT) in pediatric surgery were performed and results obtained are summarized below.1. Plasma and urinary levels of AZT were measured in 6 neonate patients following drip-infusion for 1 hour of AZT (dose of AZT: 20mg/kg). Plasma levels reached their peak (42.3-50.4 /ig/ml) at the end of infusion or in 1 hour thereafter except in case 2. In case 2, plasma level reached its peak (36.6 jug/ml) at 2 hours after the end of infusion. Plasma levels of AZT decreased rapidly after reaching their peaks, and plasma half-lives (T 1/2) were 1.852-.84 hours. Urinary recovery rates were 15.7-65 3%.",

author = "Yura Jiro and Suzuki Tatsuya and Hashimoto Takashi and Nakamura Tsukasa and Shimizu Yasunobu and Minami Munehito and Kamiya Yasuhiro and Narita Hiroshi and Tsuruga Nobuatsu",

year = "1990",

doi = "10.11553/antibiotics1968b.43.534",

language = "English",

volume = "43",

pages = "534--542",

journal = "The Journal of antibiotics. Ser. B",

issn = "0368-2781",

publisher = "Japan Antibiotics Research Association",

number = "3",

}

Pharmacokinetics and clinical evaluation of aztreonam in pediatric surgery. / Jiro, Yura; Tatsuya, Suzuki; Takashi, Hashimoto; Tsukasa, Nakamura; Yasunobu, Shimizu; Munehito, Minami; Yasuhiro, Kamiya; Hiroshi, Narita; Nobuatsu, Tsuruga.

In: the japanese journal of antibiotics, Vol. 43, No. 3, 1990, p. 534-542.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Pharmacokinetics and clinical evaluation of aztreonam in pediatric surgery

AU - Jiro, Yura

AU - Tatsuya, Suzuki

AU - Takashi, Hashimoto

AU - Tsukasa, Nakamura

AU - Yasunobu, Shimizu

AU - Munehito, Minami

AU - Yasuhiro, Kamiya

AU - Hiroshi, Narita

AU - Nobuatsu, Tsuruga

PY - 1990

Y1 - 1990

N2 - Pharmacokinetic and clinical studies on aztreonam (AZT) in pediatric surgery were performed and results obtained are summarized below.1. Plasma and urinary levels of AZT were measured in 6 neonate patients following drip-infusion for 1 hour of AZT (dose of AZT: 20mg/kg). Plasma levels reached their peak (42.3-50.4 /ig/ml) at the end of infusion or in 1 hour thereafter except in case 2. In case 2, plasma level reached its peak (36.6 jug/ml) at 2 hours after the end of infusion. Plasma levels of AZT decreased rapidly after reaching their peaks, and plasma half-lives (T 1/2) were 1.852-.84 hours. Urinary recovery rates were 15.7-65 3%.

AB - Pharmacokinetic and clinical studies on aztreonam (AZT) in pediatric surgery were performed and results obtained are summarized below.1. Plasma and urinary levels of AZT were measured in 6 neonate patients following drip-infusion for 1 hour of AZT (dose of AZT: 20mg/kg). Plasma levels reached their peak (42.3-50.4 /ig/ml) at the end of infusion or in 1 hour thereafter except in case 2. In case 2, plasma level reached its peak (36.6 jug/ml) at 2 hours after the end of infusion. Plasma levels of AZT decreased rapidly after reaching their peaks, and plasma half-lives (T 1/2) were 1.852-.84 hours. Urinary recovery rates were 15.7-65 3%.

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