Pharmacokinetics and clinical evaluation of aztreonam in pediatric surgery

Yura Jiro, Suzuki Tatsuya, Hashimoto Takashi, Nakamura Tsukasa, Shimizu Yasunobu, Minami Munehito, Kamiya Yasuhiro, Narita Hiroshi, Tsuruga Nobuatsu

Research output: Contribution to journalArticlepeer-review

Abstract

Pharmacokinetic and clinical studies on aztreonam (AZT) in pediatric surgery were performed and results obtained are summarized below.1. Plasma and urinary levels of AZT were measured in 6 neonate patients following drip-infusion for 1 hour of AZT (dose of AZT: 20mg/kg). Plasma levels reached their peak (42.3-50.4 /ig/ml) at the end of infusion or in 1 hour thereafter except in case 2. In case 2, plasma level reached its peak (36.6 jug/ml) at 2 hours after the end of infusion. Plasma levels of AZT decreased rapidly after reaching their peaks, and plasma half-lives (T 1/2) were 1.852-.84 hours. Urinary recovery rates were 15.7-65 3%.

Original languageEnglish
Pages (from-to)534-542
Number of pages9
Journalthe japanese journal of antibiotics
Volume43
Issue number3
DOIs
Publication statusPublished - 1990

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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