Abstract
Pharmacokinetic and clinical studies on aztreonam (AZT) in pediatric surgery were performed and results obtained are summarized below.1. Plasma and urinary levels of AZT were measured in 6 neonate patients following drip-infusion for 1 hour of AZT (dose of AZT: 20mg/kg). Plasma levels reached their peak (42.3-50.4 /ig/ml) at the end of infusion or in 1 hour thereafter except in case 2. In case 2, plasma level reached its peak (36.6 jug/ml) at 2 hours after the end of infusion. Plasma levels of AZT decreased rapidly after reaching their peaks, and plasma half-lives (T 1/2) were 1.852-.84 hours. Urinary recovery rates were 15.7-65 3%.
Original language | English |
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Pages (from-to) | 534-542 |
Number of pages | 9 |
Journal | the japanese journal of antibiotics |
Volume | 43 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1990 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Microbiology (medical)
- Pharmacology (medical)
- Infectious Diseases