TY - JOUR
T1 - Pharmacokinetics and clinical evaluation of aztreonam in pediatric surgery
AU - Jiro, Yura
AU - Tatsuya, Suzuki
AU - Takashi, Hashimoto
AU - Tsukasa, Nakamura
AU - Yasunobu, Shimizu
AU - Munehito, Minami
AU - Yasuhiro, Kamiya
AU - Hiroshi, Narita
AU - Nobuatsu, Tsuruga
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1990
Y1 - 1990
N2 - Pharmacokinetic and clinical studies on aztreonam (AZT) in pediatric surgery were performed and results obtained are summarized below.1. Plasma and urinary levels of AZT were measured in 6 neonate patients following drip-infusion for 1 hour of AZT (dose of AZT: 20mg/kg). Plasma levels reached their peak (42.3-50.4 /ig/ml) at the end of infusion or in 1 hour thereafter except in case 2. In case 2, plasma level reached its peak (36.6 jug/ml) at 2 hours after the end of infusion. Plasma levels of AZT decreased rapidly after reaching their peaks, and plasma half-lives (T 1/2) were 1.852-.84 hours. Urinary recovery rates were 15.7-65 3%.
AB - Pharmacokinetic and clinical studies on aztreonam (AZT) in pediatric surgery were performed and results obtained are summarized below.1. Plasma and urinary levels of AZT were measured in 6 neonate patients following drip-infusion for 1 hour of AZT (dose of AZT: 20mg/kg). Plasma levels reached their peak (42.3-50.4 /ig/ml) at the end of infusion or in 1 hour thereafter except in case 2. In case 2, plasma level reached its peak (36.6 jug/ml) at 2 hours after the end of infusion. Plasma levels of AZT decreased rapidly after reaching their peaks, and plasma half-lives (T 1/2) were 1.852-.84 hours. Urinary recovery rates were 15.7-65 3%.
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U2 - 10.11553/antibiotics1968b.43.534
DO - 10.11553/antibiotics1968b.43.534
M3 - Article
C2 - 2374303
AN - SCOPUS:0025034467
VL - 43
SP - 534
EP - 542
JO - The Journal of antibiotics. Ser. B
JF - The Journal of antibiotics. Ser. B
SN - 0368-2781
IS - 3
ER -