Pharmacokinetics and clinical evaluation of aztreonam in pediatric surgery

Yura Jiro; Suzuki Tatsuya; Hashimoto Takashi; Nakamura Tsukasa; Shimizu Yasunobu; Minami Munehito; Kamiya Yasuhiro; Narita Hiroshi; Tsuruga Nobuatsu

doi:10.11553/antibiotics1968b.43.534

Pharmacokinetics and clinical evaluation of aztreonam in pediatric surgery

Yura Jiro, Suzuki Tatsuya, Hashimoto Takashi, Nakamura Tsukasa, Shimizu Yasunobu, Minami Munehito, Kamiya Yasuhiro, Narita Hiroshi, Tsuruga Nobuatsu

Research output: Contribution to journal › Article › peer-review

Abstract

Pharmacokinetic and clinical studies on aztreonam (AZT) in pediatric surgery were performed and results obtained are summarized below.1. Plasma and urinary levels of AZT were measured in 6 neonate patients following drip-infusion for 1 hour of AZT (dose of AZT: 20mg/kg). Plasma levels reached their peak (42.3-50.4 /ig/ml) at the end of infusion or in 1 hour thereafter except in case 2. In case 2, plasma level reached its peak (36.6 jug/ml) at 2 hours after the end of infusion. Plasma levels of AZT decreased rapidly after reaching their peaks, and plasma half-lives (T 1/2) were 1.852-.84 hours. Urinary recovery rates were 15.7-65 3%.

Original language	English
Pages (from-to)	534-542
Number of pages	9
Journal	the japanese journal of antibiotics
Volume	43
Issue number	3
DOIs	https://doi.org/10.11553/antibiotics1968b.43.534
Publication status	Published - 1990
Externally published	Yes

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Pharmacology (medical)
Infectious Diseases

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10.11553/antibiotics1968b.43.534

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title = "Pharmacokinetics and clinical evaluation of aztreonam in pediatric surgery",

abstract = "Pharmacokinetic and clinical studies on aztreonam (AZT) in pediatric surgery were performed and results obtained are summarized below.1. Plasma and urinary levels of AZT were measured in 6 neonate patients following drip-infusion for 1 hour of AZT (dose of AZT: 20mg/kg). Plasma levels reached their peak (42.3-50.4 /ig/ml) at the end of infusion or in 1 hour thereafter except in case 2. In case 2, plasma level reached its peak (36.6 jug/ml) at 2 hours after the end of infusion. Plasma levels of AZT decreased rapidly after reaching their peaks, and plasma half-lives (T 1/2) were 1.852-.84 hours. Urinary recovery rates were 15.7-65 3%.",

author = "Yura Jiro and Suzuki Tatsuya and Hashimoto Takashi and Nakamura Tsukasa and Shimizu Yasunobu and Minami Munehito and Kamiya Yasuhiro and Narita Hiroshi and Tsuruga Nobuatsu",

year = "1990",

doi = "10.11553/antibiotics1968b.43.534",

language = "English",

volume = "43",

pages = "534--542",

journal = "The Journal of antibiotics. Ser. B",

issn = "0368-2781",

publisher = "Japan Antibiotics Research Association",

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}

TY - JOUR

T1 - Pharmacokinetics and clinical evaluation of aztreonam in pediatric surgery

AU - Jiro, Yura

AU - Tatsuya, Suzuki

AU - Takashi, Hashimoto

AU - Tsukasa, Nakamura

AU - Yasunobu, Shimizu

AU - Munehito, Minami

AU - Yasuhiro, Kamiya

AU - Hiroshi, Narita

AU - Nobuatsu, Tsuruga

PY - 1990

Y1 - 1990

N2 - Pharmacokinetic and clinical studies on aztreonam (AZT) in pediatric surgery were performed and results obtained are summarized below.1. Plasma and urinary levels of AZT were measured in 6 neonate patients following drip-infusion for 1 hour of AZT (dose of AZT: 20mg/kg). Plasma levels reached their peak (42.3-50.4 /ig/ml) at the end of infusion or in 1 hour thereafter except in case 2. In case 2, plasma level reached its peak (36.6 jug/ml) at 2 hours after the end of infusion. Plasma levels of AZT decreased rapidly after reaching their peaks, and plasma half-lives (T 1/2) were 1.852-.84 hours. Urinary recovery rates were 15.7-65 3%.

AB - Pharmacokinetic and clinical studies on aztreonam (AZT) in pediatric surgery were performed and results obtained are summarized below.1. Plasma and urinary levels of AZT were measured in 6 neonate patients following drip-infusion for 1 hour of AZT (dose of AZT: 20mg/kg). Plasma levels reached their peak (42.3-50.4 /ig/ml) at the end of infusion or in 1 hour thereafter except in case 2. In case 2, plasma level reached its peak (36.6 jug/ml) at 2 hours after the end of infusion. Plasma levels of AZT decreased rapidly after reaching their peaks, and plasma half-lives (T 1/2) were 1.852-.84 hours. Urinary recovery rates were 15.7-65 3%.

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JO - The Journal of antibiotics. Ser. B

JF - The Journal of antibiotics. Ser. B

SN - 0368-2781

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ER -

Pharmacokinetics and clinical evaluation of aztreonam in pediatric surgery

Abstract

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