Pharmacokinetics and clinical studies on aztreonam in neonates and premature infants (the first report)

Fujii Ryochi; Sakata Hiroshi; Hiramoto Azuma; Inyaku Fumie; Azagami Shiro; Shiro Hiroyuki; Sunakawa Keisuke; Iwata Satoshi; Nakazawa Susumu; Sato Hajime; Niino Kenji; Toyonaga Yoshikiyo; Kawamura Ken-Ichi; Suzuki Masaharu; Nomura Toyoki; Iwai Naoichi; Taneda Yoh-Ichi; Maki Takako; Ozaki Takao; Tauchi Nobuo; Ohkura Kan-Etsu; Motohiro Takashi; Tanaka Hiroya; Shimomura Hiroshi; Yura Jiro; Yagisawa Morimasa; Hashira Shintaro; Kakehashi Hitoshi; Mori Yoshiki; Isohata Eiichi; Ishizuka Yugo; Narita Akira; Sugita Morimasa; Seo Kiwamu; Kojima Masamitsu; Inamochi Hideki; Nakamura Haruhi; Matsui Shoji; Ichikawa Takayuki; Tabuki Kazuo; Matsuda Tadashi; Koga Tatsuhiko; Fukuda Masafumi; Miyano Takeshi; Suzuki Tatsuya; Tajima Takeshi; Fujita Kozo; Mori Yoshiki; Oikawa Tadao; Saito Nobuo; Suzuki Hiroyuki; Nakamura Hironori; Arai Shojiro; Nigami Hiroyuki; Sakata Yasutaka; Inoguchi Shunji; Kimura Koh-Ichiro; Hashimoto Takashi; Meguro Hidenori; Murono Ko-Ichi; Maruyama Shizuo; Osano Mitsuru; Nakazawa Shin-Ichi; Kamiya Hitoshi; Yamakawa Masaru; Ishimoto Kohji; Tsuji Yoshiro; Nakamura Tsukasa; Abe Toshiaki; Kaeriyama Masato; Matsumoto Kimiko; Sakurai Minoru; Kuroki Shigekazu; Yamashita Fumio; Shimizu Yasunobu; Oka Toshiaki; Nakanishi Yoshiko; Haruta Tsunekazu; Minami Munehito; Yoshioka Hajime; Kamiya Yasuhiro; Narita Hiroshi; Tsuruga Nobuatsu

doi:10.11553/antibiotics1968b.43.543

Pharmacokinetics and clinical studies on aztreonam in neonates and premature infants (the first report)

Fujii Ryochi, Sakata Hiroshi, Hiramoto Azuma, Inyaku Fumie, Azagami Shiro, Shiro Hiroyuki, Sunakawa Keisuke, Iwata Satoshi, Nakazawa Susumu, Sato Hajime, Niino Kenji, Toyonaga Yoshikiyo, Kawamura Ken-Ichi, Suzuki Masaharu, Nomura Toyoki, Iwai Naoichi, Taneda Yoh-Ichi, Maki Takako, Ozaki Takao, Tauchi NobuoOhkura Kan-Etsu, Motohiro Takashi, Tanaka Hiroya, Shimomura Hiroshi, Yura Jiro, Yagisawa Morimasa, Hashira Shintaro, Kakehashi Hitoshi, Mori Yoshiki, Isohata Eiichi, Ishizuka Yugo, Narita Akira, Sugita Morimasa, Seo Kiwamu, Kojima Masamitsu, Inamochi Hideki, Nakamura Haruhi, Matsui Shoji, Ichikawa Takayuki, Tabuki Kazuo, Matsuda Tadashi, Koga Tatsuhiko, Fukuda Masafumi, Miyano Takeshi, Suzuki Tatsuya, Tajima Takeshi, Fujita Kozo, Mori Yoshiki, Oikawa Tadao, Saito Nobuo, Suzuki Hiroyuki, Nakamura Hironori, Arai Shojiro, Nigami Hiroyuki, Sakata Yasutaka, Inoguchi Shunji, Kimura Koh-Ichiro, Hashimoto Takashi, Meguro Hidenori, Murono Ko-Ichi, Maruyama Shizuo, Osano Mitsuru, Nakazawa Shin-Ichi, Kamiya Hitoshi, Yamakawa Masaru, Ishimoto Kohji, Tsuji Yoshiro, Nakamura Tsukasa, Abe Toshiaki, Kaeriyama Masato, Matsumoto Kimiko, Sakurai Minoru, Kuroki Shigekazu, Yamashita Fumio, Shimizu Yasunobu, Oka Toshiaki, Nakanishi Yoshiko, Haruta Tsunekazu, Minami Munehito, Yoshioka Hajime, Kamiya Yasuhiro, Narita Hiroshi, Tsuruga Nobuatsu

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Abstract

Pharmacokinetics and clinical study of aztreonam (AZT) in neonates and premature infants were conducted with the following results:1. Pharmacokinetics(1) Serum concentrations of AZT at 30 minutes after one-shot intravenous injection of 10 mg/kg and 20 mg/kg to neonates including premature infants were 20.6-26.6g/ml and 38.5-46.4 jug/ml, respectively, and decreased thereafter. A dose response was observed in the serum concentrations with administration of AZT 10 mg/kg and 20 mg/kg.

Original language	English
Pages (from-to)	543-562
Number of pages	20
Journal	the japanese journal of antibiotics
Volume	43
Issue number	3
DOIs	https://doi.org/10.11553/antibiotics1968b.43.543
Publication status	Published - 1990
Externally published	Yes

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Pharmacology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.11553/antibiotics1968b.43.543

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Ryochi, F., Hiroshi, S., Azuma, H., Fumie, I., Shiro, A., Hiroyuki, S., Keisuke, S., Satoshi, I., Susumu, N., Hajime, S., Kenji, N., Yoshikiyo, T., Ken-Ichi, K., Masaharu, S., Toyoki, N., Naoichi, I., Yoh-Ichi, T., Takako, M., Takao, O., ... Nobuatsu, T. (1990). Pharmacokinetics and clinical studies on aztreonam in neonates and premature infants (the first report). the japanese journal of antibiotics, 43(3), 543-562. https://doi.org/10.11553/antibiotics1968b.43.543

@article{bf916b0aea2c4ad1977050bd68259b14,

title = "Pharmacokinetics and clinical studies on aztreonam in neonates and premature infants (the first report)",

abstract = "Pharmacokinetics and clinical study of aztreonam (AZT) in neonates and premature infants were conducted with the following results:1. Pharmacokinetics(1) Serum concentrations of AZT at 30 minutes after one-shot intravenous injection of 10 mg/kg and 20 mg/kg to neonates including premature infants were 20.6-26.6g/ml and 38.5-46.4 jug/ml, respectively, and decreased thereafter. A dose response was observed in the serum concentrations with administration of AZT 10 mg/kg and 20 mg/kg.",

author = "Fujii Ryochi and Sakata Hiroshi and Hiramoto Azuma and Inyaku Fumie and Azagami Shiro and Shiro Hiroyuki and Sunakawa Keisuke and Iwata Satoshi and Nakazawa Susumu and Sato Hajime and Niino Kenji and Toyonaga Yoshikiyo and Kawamura Ken-Ichi and Suzuki Masaharu and Nomura Toyoki and Iwai Naoichi and Taneda Yoh-Ichi and Maki Takako and Ozaki Takao and Tauchi Nobuo and Ohkura Kan-Etsu and Motohiro Takashi and Tanaka Hiroya and Shimomura Hiroshi and Yura Jiro and Yagisawa Morimasa and Hashira Shintaro and Kakehashi Hitoshi and Mori Yoshiki and Isohata Eiichi and Ishizuka Yugo and Narita Akira and Sugita Morimasa and Seo Kiwamu and Kojima Masamitsu and Inamochi Hideki and Nakamura Haruhi and Matsui Shoji and Ichikawa Takayuki and Tabuki Kazuo and Matsuda Tadashi and Koga Tatsuhiko and Fukuda Masafumi and Miyano Takeshi and Suzuki Tatsuya and Tajima Takeshi and Fujita Kozo and Mori Yoshiki and Oikawa Tadao and Saito Nobuo and Suzuki Hiroyuki and Nakamura Hironori and Arai Shojiro and Nigami Hiroyuki and Sakata Yasutaka and Inoguchi Shunji and Kimura Koh-Ichiro and Hashimoto Takashi and Meguro Hidenori and Murono Ko-Ichi and Maruyama Shizuo and Osano Mitsuru and Nakazawa Shin-Ichi and Kamiya Hitoshi and Yamakawa Masaru and Ishimoto Kohji and Tsuji Yoshiro and Nakamura Tsukasa and Abe Toshiaki and Kaeriyama Masato and Matsumoto Kimiko and Sakurai Minoru and Kuroki Shigekazu and Yamashita Fumio and Shimizu Yasunobu and Oka Toshiaki and Nakanishi Yoshiko and Haruta Tsunekazu and Minami Munehito and Yoshioka Hajime and Kamiya Yasuhiro and Narita Hiroshi and Tsuruga Nobuatsu",

year = "1990",

doi = "10.11553/antibiotics1968b.43.543",

language = "English",

volume = "43",

pages = "543--562",

journal = "the japanese journal of antibiotics",

issn = "0368-2781",

publisher = "Japan Antibiotics Research Association",

number = "3",

}

Ryochi, F, Hiroshi, S, Azuma, H, Fumie, I, Shiro, A, Hiroyuki, S, Keisuke, S, Satoshi, I, Susumu, N, Hajime, S, Kenji, N, Yoshikiyo, T, Ken-Ichi, K, Masaharu, S, Toyoki, N, Naoichi, I, Yoh-Ichi, T, Takako, M, Takao, O, Nobuo, T, Kan-Etsu, O, Takashi, M, Hiroya, T, Hiroshi, S, Jiro, Y, Morimasa, Y, Shintaro, H, Hitoshi, K, Yoshiki, M, Eiichi, I, Yugo, I, Akira, N, Morimasa, S, Kiwamu, S, Masamitsu, K, Hideki, I, Haruhi, N, Shoji, M, Takayuki, I, Kazuo, T, Tadashi, M, Tatsuhiko, K, Masafumi, F, Takeshi, M, Tatsuya, S, Takeshi, T, Kozo, F, Yoshiki, M, Tadao, O, Nobuo, S, Hiroyuki, S, Hironori, N, Shojiro, A, Hiroyuki, N, Yasutaka, S, Shunji, I, Koh-Ichiro, K, Takashi, H, Hidenori, M, Ko-Ichi, M, Shizuo, M, Mitsuru, O, Shin-Ichi, N, Hitoshi, K, Masaru, Y, Kohji, I, Yoshiro, T, Tsukasa, N, Toshiaki, A, Masato, K, Kimiko, M, Minoru, S, Shigekazu, K, Fumio, Y, Yasunobu, S, Toshiaki, O, Yoshiko, N, Tsunekazu, H, Munehito, M, Hajime, Y, Yasuhiro, K, Hiroshi, N & Nobuatsu, T 1990, 'Pharmacokinetics and clinical studies on aztreonam in neonates and premature infants (the first report)', the japanese journal of antibiotics, vol. 43, no. 3, pp. 543-562. https://doi.org/10.11553/antibiotics1968b.43.543

TY - JOUR

T1 - Pharmacokinetics and clinical studies on aztreonam in neonates and premature infants (the first report)

AU - Ryochi, Fujii

AU - Hiroshi, Sakata

AU - Azuma, Hiramoto

AU - Fumie, Inyaku

AU - Shiro, Azagami

AU - Hiroyuki, Shiro

AU - Keisuke, Sunakawa

AU - Satoshi, Iwata

AU - Susumu, Nakazawa

AU - Hajime, Sato

AU - Kenji, Niino

AU - Yoshikiyo, Toyonaga

AU - Ken-Ichi, Kawamura

AU - Masaharu, Suzuki

AU - Toyoki, Nomura

AU - Naoichi, Iwai

AU - Yoh-Ichi, Taneda

AU - Takako, Maki

AU - Takao, Ozaki

AU - Nobuo, Tauchi

AU - Kan-Etsu, Ohkura

AU - Takashi, Motohiro

AU - Hiroya, Tanaka

AU - Hiroshi, Shimomura

AU - Jiro, Yura

AU - Morimasa, Yagisawa

AU - Shintaro, Hashira

AU - Hitoshi, Kakehashi

AU - Yoshiki, Mori

AU - Eiichi, Isohata

AU - Yugo, Ishizuka

AU - Akira, Narita

AU - Morimasa, Sugita

AU - Kiwamu, Seo

AU - Masamitsu, Kojima

AU - Hideki, Inamochi

AU - Haruhi, Nakamura

AU - Shoji, Matsui

AU - Takayuki, Ichikawa

AU - Kazuo, Tabuki

AU - Tadashi, Matsuda

AU - Tatsuhiko, Koga

AU - Masafumi, Fukuda

AU - Takeshi, Miyano

AU - Tatsuya, Suzuki

AU - Takeshi, Tajima

AU - Kozo, Fujita

AU - Yoshiki, Mori

AU - Tadao, Oikawa

AU - Nobuo, Saito

AU - Hiroyuki, Suzuki

AU - Hironori, Nakamura

AU - Shojiro, Arai

AU - Hiroyuki, Nigami

AU - Yasutaka, Sakata

AU - Shunji, Inoguchi

AU - Koh-Ichiro, Kimura

AU - Takashi, Hashimoto

AU - Hidenori, Meguro

AU - Ko-Ichi, Murono

AU - Shizuo, Maruyama

AU - Mitsuru, Osano

AU - Shin-Ichi, Nakazawa

AU - Hitoshi, Kamiya

AU - Masaru, Yamakawa

AU - Kohji, Ishimoto

AU - Yoshiro, Tsuji

AU - Tsukasa, Nakamura

AU - Toshiaki, Abe

AU - Masato, Kaeriyama

AU - Kimiko, Matsumoto

AU - Minoru, Sakurai

AU - Shigekazu, Kuroki

AU - Fumio, Yamashita

AU - Yasunobu, Shimizu

AU - Toshiaki, Oka

AU - Yoshiko, Nakanishi

AU - Tsunekazu, Haruta

AU - Munehito, Minami

AU - Hajime, Yoshioka

AU - Yasuhiro, Kamiya

AU - Hiroshi, Narita

AU - Nobuatsu, Tsuruga

PY - 1990

Y1 - 1990

N2 - Pharmacokinetics and clinical study of aztreonam (AZT) in neonates and premature infants were conducted with the following results:1. Pharmacokinetics(1) Serum concentrations of AZT at 30 minutes after one-shot intravenous injection of 10 mg/kg and 20 mg/kg to neonates including premature infants were 20.6-26.6g/ml and 38.5-46.4 jug/ml, respectively, and decreased thereafter. A dose response was observed in the serum concentrations with administration of AZT 10 mg/kg and 20 mg/kg.

AB - Pharmacokinetics and clinical study of aztreonam (AZT) in neonates and premature infants were conducted with the following results:1. Pharmacokinetics(1) Serum concentrations of AZT at 30 minutes after one-shot intravenous injection of 10 mg/kg and 20 mg/kg to neonates including premature infants were 20.6-26.6g/ml and 38.5-46.4 jug/ml, respectively, and decreased thereafter. A dose response was observed in the serum concentrations with administration of AZT 10 mg/kg and 20 mg/kg.

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UR - http://www.scopus.com/inward/citedby.url?scp=0025115537&partnerID=8YFLogxK

U2 - 10.11553/antibiotics1968b.43.543

DO - 10.11553/antibiotics1968b.43.543

M3 - Article

C2 - 2197468

AN - SCOPUS:0025115537

SN - 0368-2781

VL - 43

SP - 543

EP - 562

JO - the japanese journal of antibiotics

JF - the japanese journal of antibiotics

IS - 3

ER -

Pharmacokinetics and clinical studies on aztreonam in neonates and premature infants (the first report)

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