Pharmacokinetics of gefitinib in a patient with non-small cell lung cancer undergoing continuous ambulatory peritoneal dialysis

Teppei Yamaguchi, Sumito Isogai, Takuya Okamura, Sakurako Uozu, Yuki Mieno, Tami Hoshino, Yasuhiro Goto, Masamichi Hayashi, Toru Nakanishi, Kazuyoshi Imaizumi

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Abstract

A 72-year-old man undergoing continuous ambulatory peritoneal dialysis (CAPD) for chronic renal failure and who had undergone right upper lobectomy for lung adenocarcinoma (pT2aN0M0) 2 years ago was admitted for recurrence of lung cancer presenting as multiple brain metastases. An epidermal growth factor receptor mutation analysis of his lung cancer revealed a deletion of 15 nucleotides (E746-A750) in exon 19. After whole-brain radiotherapy, we started daily administration of 250 mg gefitinib under the continuation of CAPD and performed a pharmacokinetic analysis. We speculated that the plasma concentration of gefitinib reached the steady state at least by day 16 after the start of gefitinib (626.6 ng/ml at trough level). On day 46, the plasma concentration was 538.4 ng/ml at trough level and the concentration in the peritoneal dialysis fluid was 34.6 ng/ml, suggesting that CAPD appeared to have little effect on the pharmacokinetics of gefitinib. During gefitinib therapy, there were no significant adverse events except for grade 2 diarrhea. Gefitinib could be safely administered to a patient undergoing CAPD.

Original languageEnglish
Pages (from-to)78-82
Number of pages5
JournalCase Reports in Oncology
Volume8
Issue number1
DOIs
Publication statusPublished - 22-05-2015

All Science Journal Classification (ASJC) codes

  • Oncology

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    Yamaguchi, T., Isogai, S., Okamura, T., Uozu, S., Mieno, Y., Hoshino, T., Goto, Y., Hayashi, M., Nakanishi, T., & Imaizumi, K. (2015). Pharmacokinetics of gefitinib in a patient with non-small cell lung cancer undergoing continuous ambulatory peritoneal dialysis. Case Reports in Oncology, 8(1), 78-82. https://doi.org/10.1159/000375485