Pharmacological action of eptazocine (l-1,4- dimethyl-10-hydroxy-2, 3,4, 5,6,7-hexahydro-l,6-methano-lH-4-benzazonine). (V). A comparison of eptazocine, pentazocine and morphine with regard to ability of tolerance development after successive administration

Toshitaka Nabeshima, Shigeyuki Yamada, Tsutomu Kameyama

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Abstract

It was investigated whether tolerance to the pharmacological actions and cross-tolerance between eptazocine and pentazocine/morphine were developed by successive administration of eptazocine. In the experiments of mice, successive administration of eptazocine failed to decrease the pharmacological actions of eptazocine on the acetic acid-induced writhing, the pressure and the wheel cage methods. Cross-tolerance between eptazocine and pentazocine/morphine was not observed. Tolerance to the actions of pentazocine and morphine was developed on the wheel cage and the acetic acid-induced writhing/pressure methods, respectively. Cross-tolerance between pentazocine and morphine was also developed on the pressure method. On the tail flick method of rats, tolerance to the action of eptazocine was observed, similar to morphine, but not cross-tolerance between eptazocine and morphine. These results suggest that there is species difference between mice and rats with regard to the ability of tolerance development and that the mechanisms of tolerance development between eptazocine and pentazocine/morphine may be different since eptazocine failed to show cross tolerance to these analgesics.

Original languageEnglish
Pages (from-to)619-627
Number of pages9
JournalFolia Pharmacologica Japonica
Volume87
Issue number6
DOIs
Publication statusPublished - 01-01-1986

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Pentazocine
Morphine
Pharmacology
Pressure
Acetic Acid
eptazocine
Analgesics
Tail

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

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title = "Pharmacological action of eptazocine (l-1,4- dimethyl-10-hydroxy-2, 3,4, 5,6,7-hexahydro-l,6-methano-lH-4-benzazonine). (V). A comparison of eptazocine, pentazocine and morphine with regard to ability of tolerance development after successive administration",
abstract = "It was investigated whether tolerance to the pharmacological actions and cross-tolerance between eptazocine and pentazocine/morphine were developed by successive administration of eptazocine. In the experiments of mice, successive administration of eptazocine failed to decrease the pharmacological actions of eptazocine on the acetic acid-induced writhing, the pressure and the wheel cage methods. Cross-tolerance between eptazocine and pentazocine/morphine was not observed. Tolerance to the actions of pentazocine and morphine was developed on the wheel cage and the acetic acid-induced writhing/pressure methods, respectively. Cross-tolerance between pentazocine and morphine was also developed on the pressure method. On the tail flick method of rats, tolerance to the action of eptazocine was observed, similar to morphine, but not cross-tolerance between eptazocine and morphine. These results suggest that there is species difference between mice and rats with regard to the ability of tolerance development and that the mechanisms of tolerance development between eptazocine and pentazocine/morphine may be different since eptazocine failed to show cross tolerance to these analgesics.",
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