Pharmacological action of eptazocine (l-1,4-dimethyl-10-hydroxy-2,3,4.5,6,7-hexahydro-1,6-methano-1 H-4-benzazonine)

Tsutomu Kameyama, Toshitaka Nabeshima, Kazumasa Yamaguchi, Katsuo Kamata, Shigeru Okltyama, Hisanao Tsuji, Sakihito Sakakibara

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Pharmacological actions of eptazocine on the central nervous system were investigated by pharmacological and behavioral methods. Eptazocine produced sedation at low doses and Straub tail reaction in mice and ataxia in rats at high doses. In mice, eptazocine caused decreases in the spontaneous locomotor activities measured by the wheel cage and Animex methods, but caused an increase of the response in rats as determined by the open-field method. Eptazocine caused impairment of performance in the rotarod test and the traction test in mice, a decrease of activity of EMG, and an inhibition of flexor reflex in rats. Eptazocine decreased body temperature, potentiated pentobarbital-induced sleeping, and inhibited convulsion caused by pentylenetetrazol in mice. Fighting behavior induced by electric shock and central stimulation effect of methamphetamine were inhibited by eptazocine in mice. Eptazocine showed an inhibition of avoidance behavior in shuttle and skinner boxes in rats. These results suggest that eptazocine produces a non-specific inhibitory action on the central nervous system.

Original languageEnglish
Pages (from-to)629-645
Number of pages17
JournalFolia Pharmacologica Japonica
Volume78
DOIs
Publication statusPublished - 01-01-1981
Externally publishedYes

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Pharmacology
Central Nervous System
Rotarod Performance Test
Avoidance Learning
Pentylenetetrazole
Methamphetamine
eptazocine
Traction
Pentobarbital
Ataxia
Locomotion
Body Temperature
Reflex
Tail
Shock
Seizures
Inhibition (Psychology)

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Kameyama, Tsutomu ; Nabeshima, Toshitaka ; Yamaguchi, Kazumasa ; Kamata, Katsuo ; Okltyama, Shigeru ; Tsuji, Hisanao ; Sakakibara, Sakihito. / Pharmacological action of eptazocine (l-1,4-dimethyl-10-hydroxy-2,3,4.5,6,7-hexahydro-1,6-methano-1 H-4-benzazonine). In: Folia Pharmacologica Japonica. 1981 ; Vol. 78. pp. 629-645.
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Pharmacological action of eptazocine (l-1,4-dimethyl-10-hydroxy-2,3,4.5,6,7-hexahydro-1,6-methano-1 H-4-benzazonine). / Kameyama, Tsutomu; Nabeshima, Toshitaka; Yamaguchi, Kazumasa; Kamata, Katsuo; Okltyama, Shigeru; Tsuji, Hisanao; Sakakibara, Sakihito.

In: Folia Pharmacologica Japonica, Vol. 78, 01.01.1981, p. 629-645.

Research output: Contribution to journalArticle

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AU - Okltyama, Shigeru

AU - Tsuji, Hisanao

AU - Sakakibara, Sakihito

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N2 - Pharmacological actions of eptazocine on the central nervous system were investigated by pharmacological and behavioral methods. Eptazocine produced sedation at low doses and Straub tail reaction in mice and ataxia in rats at high doses. In mice, eptazocine caused decreases in the spontaneous locomotor activities measured by the wheel cage and Animex methods, but caused an increase of the response in rats as determined by the open-field method. Eptazocine caused impairment of performance in the rotarod test and the traction test in mice, a decrease of activity of EMG, and an inhibition of flexor reflex in rats. Eptazocine decreased body temperature, potentiated pentobarbital-induced sleeping, and inhibited convulsion caused by pentylenetetrazol in mice. Fighting behavior induced by electric shock and central stimulation effect of methamphetamine were inhibited by eptazocine in mice. Eptazocine showed an inhibition of avoidance behavior in shuttle and skinner boxes in rats. These results suggest that eptazocine produces a non-specific inhibitory action on the central nervous system.

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