TY - JOUR
T1 - Pharmacological targeting of bone marrow mesenchymal stromal/stem cells for the treatment of hematological disorders
AU - Sugino, Noriko
AU - Ichinohe, Tatsuo
AU - Takaori-Kondo, Akifumi
AU - Maekawa, Taira
AU - Miura, Yasuo
N1 - Publisher Copyright:
© 2017 The Author(s).
PY - 2017/4/3
Y1 - 2017/4/3
N2 - The therapeutic effects of mesenchymal stromal/stem cells (MSCs) are mainly based on three characteristics: immunomodulation, tissue regeneration, and hematopoietic support. Cell therapy using culture-expanded MSCs is effective in some intractable bone and hemato-immune disorders; however, its efficacy is limited. In this article, we review the previous efforts to improve the clinical outcomes of cell therapy using MSCs for such disorders. We describe pharmacological targeting of endogenous bone marrow-derived MSCs as a crucial quality-based intervention to establish more effective MSC-based therapies.
AB - The therapeutic effects of mesenchymal stromal/stem cells (MSCs) are mainly based on three characteristics: immunomodulation, tissue regeneration, and hematopoietic support. Cell therapy using culture-expanded MSCs is effective in some intractable bone and hemato-immune disorders; however, its efficacy is limited. In this article, we review the previous efforts to improve the clinical outcomes of cell therapy using MSCs for such disorders. We describe pharmacological targeting of endogenous bone marrow-derived MSCs as a crucial quality-based intervention to establish more effective MSC-based therapies.
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U2 - 10.1186/s41232-017-0038-5
DO - 10.1186/s41232-017-0038-5
M3 - Review article
AN - SCOPUS:85042339392
SN - 1880-9693
VL - 37
JO - Inflammation and Regeneration
JF - Inflammation and Regeneration
IS - 1
M1 - 7
ER -