Phencyclidine increases the extracellular acetylcholine level in the rat parietal cortex partly through sigma receptors

M. Ohzeki, M. Hasegawa, T. Katoh, K. Yamada, T. Hasegawa, H. Furukawa, Toshitaka Nabeshima

Research output: Contribution to journalArticle

Abstract

The effects of sigma receptor antagonists on phencyclidine (PCP)-induced increase in the extracellular acetylcholine (ACh) level in the rat parietal cortex were examined in freely-moving rats by using the in vive brain microdialysis method. PCP increased the extracellular ACh level in a dose- dependent manner. The effect of PCP was diminished by the pretreatment with sigma receptor antagonists, N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy) phenyl]-ethylamine monohydrochloride (NE-100). These results suggest that PCP-induced increase in the extracellular ACh level in the rat parietal cortex is partly mediated by sigma receptors.

Original languageEnglish
Pages (from-to)97-103
Number of pages7
JournalResearch Communications in Alcohol and Substances of Abuse
Volume16
Issue number3
Publication statusPublished - 01-12-1995
Externally publishedYes

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sigma Receptors
Phencyclidine
Parietal Lobe
Acetylcholine
Rats
Microdialysis
Brain
N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Toxicology

Cite this

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abstract = "The effects of sigma receptor antagonists on phencyclidine (PCP)-induced increase in the extracellular acetylcholine (ACh) level in the rat parietal cortex were examined in freely-moving rats by using the in vive brain microdialysis method. PCP increased the extracellular ACh level in a dose- dependent manner. The effect of PCP was diminished by the pretreatment with sigma receptor antagonists, N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy) phenyl]-ethylamine monohydrochloride (NE-100). These results suggest that PCP-induced increase in the extracellular ACh level in the rat parietal cortex is partly mediated by sigma receptors.",
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Phencyclidine increases the extracellular acetylcholine level in the rat parietal cortex partly through sigma receptors. / Ohzeki, M.; Hasegawa, M.; Katoh, T.; Yamada, K.; Hasegawa, T.; Furukawa, H.; Nabeshima, Toshitaka.

In: Research Communications in Alcohol and Substances of Abuse, Vol. 16, No. 3, 01.12.1995, p. 97-103.

Research output: Contribution to journalArticle

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T1 - Phencyclidine increases the extracellular acetylcholine level in the rat parietal cortex partly through sigma receptors

AU - Ohzeki, M.

AU - Hasegawa, M.

AU - Katoh, T.

AU - Yamada, K.

AU - Hasegawa, T.

AU - Furukawa, H.

AU - Nabeshima, Toshitaka

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