Phencyclidine increases the extracellular acetylcholine level in the rat parietal cortex partly through sigma receptors

M. Ohzeki, M. Hasegawa, T. Katoh, K. Yamada, T. Hasegawa, H. Furukawa, T. Nabeshima

Research output: Contribution to journalArticle

Abstract

The effects of sigma receptor antagonists on phencyclidine (PCP)-induced increase in the extracellular acetylcholine (ACh) level in the rat parietal cortex were examined in freely-moving rats by using the in vive brain microdialysis method. PCP increased the extracellular ACh level in a dose- dependent manner. The effect of PCP was diminished by the pretreatment with sigma receptor antagonists, N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy) phenyl]-ethylamine monohydrochloride (NE-100). These results suggest that PCP-induced increase in the extracellular ACh level in the rat parietal cortex is partly mediated by sigma receptors.

Original languageEnglish
Pages (from-to)97-103
Number of pages7
JournalResearch Communications in Alcohol and Substances of Abuse
Volume16
Issue number3
Publication statusPublished - 1995

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Toxicology

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    Ohzeki, M., Hasegawa, M., Katoh, T., Yamada, K., Hasegawa, T., Furukawa, H., & Nabeshima, T. (1995). Phencyclidine increases the extracellular acetylcholine level in the rat parietal cortex partly through sigma receptors. Research Communications in Alcohol and Substances of Abuse, 16(3), 97-103.