Phencyclidine increases the extracellular acetylcholine level in the rat parietal cortex partly through sigma receptors

M. Ohzeki; M. Hasegawa; T. Katoh; K. Yamada; T. Hasegawa; H. Furukawa; Toshitaka Nabeshima

Phencyclidine increases the extracellular acetylcholine level in the rat parietal cortex partly through sigma receptors

M. Ohzeki, M. Hasegawa, T. Katoh, K. Yamada, T. Hasegawa, H. Furukawa, Toshitaka Nabeshima

Research output: Contribution to journal › Article › peer-review

Abstract

The effects of sigma receptor antagonists on phencyclidine (PCP)-induced increase in the extracellular acetylcholine (ACh) level in the rat parietal cortex were examined in freely-moving rats by using the in vive brain microdialysis method. PCP increased the extracellular ACh level in a dose- dependent manner. The effect of PCP was diminished by the pretreatment with sigma receptor antagonists, N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy) phenyl]-ethylamine monohydrochloride (NE-100). These results suggest that PCP-induced increase in the extracellular ACh level in the rat parietal cortex is partly mediated by sigma receptors.

Original language	English
Pages (from-to)	97-103
Number of pages	7
Journal	Research Communications in Alcohol and Substances of Abuse
Volume	16
Issue number	3
Publication status	Published - 1995
Externally published	Yes

All Science Journal Classification (ASJC) codes

Medicine (miscellaneous)
Toxicology

Cite this

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title = "Phencyclidine increases the extracellular acetylcholine level in the rat parietal cortex partly through sigma receptors",

abstract = "The effects of sigma receptor antagonists on phencyclidine (PCP)-induced increase in the extracellular acetylcholine (ACh) level in the rat parietal cortex were examined in freely-moving rats by using the in vive brain microdialysis method. PCP increased the extracellular ACh level in a dose- dependent manner. The effect of PCP was diminished by the pretreatment with sigma receptor antagonists, N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy) phenyl]-ethylamine monohydrochloride (NE-100). These results suggest that PCP-induced increase in the extracellular ACh level in the rat parietal cortex is partly mediated by sigma receptors.",

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T1 - Phencyclidine increases the extracellular acetylcholine level in the rat parietal cortex partly through sigma receptors

AU - Ohzeki, M.

AU - Hasegawa, M.

AU - Katoh, T.

AU - Yamada, K.

AU - Hasegawa, T.

AU - Furukawa, H.

AU - Nabeshima, Toshitaka

PY - 1995

Y1 - 1995

N2 - The effects of sigma receptor antagonists on phencyclidine (PCP)-induced increase in the extracellular acetylcholine (ACh) level in the rat parietal cortex were examined in freely-moving rats by using the in vive brain microdialysis method. PCP increased the extracellular ACh level in a dose- dependent manner. The effect of PCP was diminished by the pretreatment with sigma receptor antagonists, N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy) phenyl]-ethylamine monohydrochloride (NE-100). These results suggest that PCP-induced increase in the extracellular ACh level in the rat parietal cortex is partly mediated by sigma receptors.

AB - The effects of sigma receptor antagonists on phencyclidine (PCP)-induced increase in the extracellular acetylcholine (ACh) level in the rat parietal cortex were examined in freely-moving rats by using the in vive brain microdialysis method. PCP increased the extracellular ACh level in a dose- dependent manner. The effect of PCP was diminished by the pretreatment with sigma receptor antagonists, N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy) phenyl]-ethylamine monohydrochloride (NE-100). These results suggest that PCP-induced increase in the extracellular ACh level in the rat parietal cortex is partly mediated by sigma receptors.

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SN - 1080-8388

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JF - Research Communications in Alcohol and Substances of Abuse

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ER -

Phencyclidine increases the extracellular acetylcholine level in the rat parietal cortex partly through sigma receptors

Abstract

All Science Journal Classification (ASJC) codes

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