Phencyclidine-induced decrease of methionine-enkephalin levels in mouse brain

Toshitaka Nabeshima; Masayuki Hiramatsu; Manabu Amano; Hiroshi Furukawa; Tsutomu Kameyama

doi:10.1016/0014-2999(82)90325-9

Phencyclidine-induced decrease of methionine-enkephalin levels in mouse brain

Toshitaka Nabeshima, Masayuki Hiramatsu, Manabu Amano, Hiroshi Furukawa, Tsutomu Kameyama

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18 Citations (Scopus)

Abstract

The effects of acute administration of phencyclidine (PCP) on the steady state levels of methionine-enkephalinin discrete brain areas were investigated in mice. The methionine-enkephalin levels in the medulla oblongata-pons and the midbrain were decreased by the administration of PCP. However, PCP induced no change of the methionine-enkephalin levels in other brain areas at the dose range of 5-20 mg/kg. These results suggest that the pharmacological effects of PCP may involve changes in enkephalinergic neuronal activity.

Original language	English
Pages (from-to)	271-273
Number of pages	3
Journal	European Journal of Pharmacology
Volume	86
Issue number	2
DOIs	https://doi.org/10.1016/0014-2999(82)90325-9
Publication status	Published - 24-12-1982
Externally published	Yes

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All Science Journal Classification (ASJC) codes

Pharmacology

Cite this

Nabeshima, T., Hiramatsu, M., Amano, M., Furukawa, H., & Kameyama, T. (1982). Phencyclidine-induced decrease of methionine-enkephalin levels in mouse brain. European Journal of Pharmacology, 86(2), 271-273. https://doi.org/10.1016/0014-2999(82)90325-9

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10.1016/0014-2999(82)90325-9