Phencyclidine-induced decrease of methionine-enkephalin levels in mouse brain

Toshitaka Nabeshima, Masayuki Hiramatsu, Manabu Amano, Hiroshi Furukawa, Tsutomu Kameyama

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


The effects of acute administration of phencyclidine (PCP) on the steady state levels of methionine-enkephalinin discrete brain areas were investigated in mice. The methionine-enkephalin levels in the medulla oblongata-pons and the midbrain were decreased by the administration of PCP. However, PCP induced no change of the methionine-enkephalin levels in other brain areas at the dose range of 5-20 mg/kg. These results suggest that the pharmacological effects of PCP may involve changes in enkephalinergic neuronal activity.

Original languageEnglish
Pages (from-to)271-273
Number of pages3
JournalEuropean Journal of Pharmacology
Issue number2
Publication statusPublished - 24-12-1982
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology


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