Abstract
The effects of acute administration of phencyclidine (PCP) on the steady state levels of methionine-enkephalinin discrete brain areas were investigated in mice. The methionine-enkephalin levels in the medulla oblongata-pons and the midbrain were decreased by the administration of PCP. However, PCP induced no change of the methionine-enkephalin levels in other brain areas at the dose range of 5-20 mg/kg. These results suggest that the pharmacological effects of PCP may involve changes in enkephalinergic neuronal activity.
| Original language | English |
|---|---|
| Pages (from-to) | 271-273 |
| Number of pages | 3 |
| Journal | European Journal of Pharmacology |
| Volume | 86 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 24-12-1982 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Pharmacology
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Phencyclidine-induced decrease of methionine-enkephalin levels in mouse brain. / Nabeshima, Toshitaka; Hiramatsu, Masayuki; Amano, Manabu; Furukawa, Hiroshi; Kameyama, Tsutomu.
In: European Journal of Pharmacology, Vol. 86, No. 2, 24.12.1982, p. 271-273.Research output: Contribution to journal › Article
TY - JOUR
T1 - Phencyclidine-induced decrease of methionine-enkephalin levels in mouse brain
AU - Nabeshima, Toshitaka
AU - Hiramatsu, Masayuki
AU - Amano, Manabu
AU - Furukawa, Hiroshi
AU - Kameyama, Tsutomu
PY - 1982/12/24
Y1 - 1982/12/24
N2 - The effects of acute administration of phencyclidine (PCP) on the steady state levels of methionine-enkephalinin discrete brain areas were investigated in mice. The methionine-enkephalin levels in the medulla oblongata-pons and the midbrain were decreased by the administration of PCP. However, PCP induced no change of the methionine-enkephalin levels in other brain areas at the dose range of 5-20 mg/kg. These results suggest that the pharmacological effects of PCP may involve changes in enkephalinergic neuronal activity.
AB - The effects of acute administration of phencyclidine (PCP) on the steady state levels of methionine-enkephalinin discrete brain areas were investigated in mice. The methionine-enkephalin levels in the medulla oblongata-pons and the midbrain were decreased by the administration of PCP. However, PCP induced no change of the methionine-enkephalin levels in other brain areas at the dose range of 5-20 mg/kg. These results suggest that the pharmacological effects of PCP may involve changes in enkephalinergic neuronal activity.
UR - http://www.scopus.com/inward/record.url?scp=0020414805&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020414805&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(82)90325-9
DO - 10.1016/0014-2999(82)90325-9
M3 - Article
C2 - 7160437
AN - SCOPUS:0020414805
VL - 86
SP - 271
EP - 273
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 2
ER -