Phencyclidine-induced decrease of methionine-enkephalin levels in mouse brain

Toshitaka Nabeshima, Masayuki Hiramatsu, Manabu Amano, Hiroshi Furukawa, Tsutomu Kameyama

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The effects of acute administration of phencyclidine (PCP) on the steady state levels of methionine-enkephalinin discrete brain areas were investigated in mice. The methionine-enkephalin levels in the medulla oblongata-pons and the midbrain were decreased by the administration of PCP. However, PCP induced no change of the methionine-enkephalin levels in other brain areas at the dose range of 5-20 mg/kg. These results suggest that the pharmacological effects of PCP may involve changes in enkephalinergic neuronal activity.

Original languageEnglish
Pages (from-to)271-273
Number of pages3
JournalEuropean Journal of Pharmacology
Volume86
Issue number2
DOIs
Publication statusPublished - 24-12-1982
Externally publishedYes

Fingerprint

Phencyclidine
Methionine Enkephalin
Medulla Oblongata
Pons
Brain
Mesencephalon
Methionine
Pharmacology

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Nabeshima, Toshitaka ; Hiramatsu, Masayuki ; Amano, Manabu ; Furukawa, Hiroshi ; Kameyama, Tsutomu. / Phencyclidine-induced decrease of methionine-enkephalin levels in mouse brain. In: European Journal of Pharmacology. 1982 ; Vol. 86, No. 2. pp. 271-273.
@article{a94a5205815b4ae59b75f94f0c59d9c7,
title = "Phencyclidine-induced decrease of methionine-enkephalin levels in mouse brain",
abstract = "The effects of acute administration of phencyclidine (PCP) on the steady state levels of methionine-enkephalinin discrete brain areas were investigated in mice. The methionine-enkephalin levels in the medulla oblongata-pons and the midbrain were decreased by the administration of PCP. However, PCP induced no change of the methionine-enkephalin levels in other brain areas at the dose range of 5-20 mg/kg. These results suggest that the pharmacological effects of PCP may involve changes in enkephalinergic neuronal activity.",
author = "Toshitaka Nabeshima and Masayuki Hiramatsu and Manabu Amano and Hiroshi Furukawa and Tsutomu Kameyama",
year = "1982",
month = "12",
day = "24",
doi = "10.1016/0014-2999(82)90325-9",
language = "English",
volume = "86",
pages = "271--273",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier",
number = "2",

}

Phencyclidine-induced decrease of methionine-enkephalin levels in mouse brain. / Nabeshima, Toshitaka; Hiramatsu, Masayuki; Amano, Manabu; Furukawa, Hiroshi; Kameyama, Tsutomu.

In: European Journal of Pharmacology, Vol. 86, No. 2, 24.12.1982, p. 271-273.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Phencyclidine-induced decrease of methionine-enkephalin levels in mouse brain

AU - Nabeshima, Toshitaka

AU - Hiramatsu, Masayuki

AU - Amano, Manabu

AU - Furukawa, Hiroshi

AU - Kameyama, Tsutomu

PY - 1982/12/24

Y1 - 1982/12/24

N2 - The effects of acute administration of phencyclidine (PCP) on the steady state levels of methionine-enkephalinin discrete brain areas were investigated in mice. The methionine-enkephalin levels in the medulla oblongata-pons and the midbrain were decreased by the administration of PCP. However, PCP induced no change of the methionine-enkephalin levels in other brain areas at the dose range of 5-20 mg/kg. These results suggest that the pharmacological effects of PCP may involve changes in enkephalinergic neuronal activity.

AB - The effects of acute administration of phencyclidine (PCP) on the steady state levels of methionine-enkephalinin discrete brain areas were investigated in mice. The methionine-enkephalin levels in the medulla oblongata-pons and the midbrain were decreased by the administration of PCP. However, PCP induced no change of the methionine-enkephalin levels in other brain areas at the dose range of 5-20 mg/kg. These results suggest that the pharmacological effects of PCP may involve changes in enkephalinergic neuronal activity.

UR - http://www.scopus.com/inward/record.url?scp=0020414805&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020414805&partnerID=8YFLogxK

U2 - 10.1016/0014-2999(82)90325-9

DO - 10.1016/0014-2999(82)90325-9

M3 - Article

VL - 86

SP - 271

EP - 273

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 2

ER -