TY - JOUR
T1 - Phencyclidine-induced decrease of methionine-enkephalin levels in mouse brain
AU - Nabeshima, Toshitaka
AU - Hiramatsu, Masayuki
AU - Amano, Manabu
AU - Furukawa, Hiroshi
AU - Kameyama, Tsutomu
PY - 1982/12/24
Y1 - 1982/12/24
N2 - The effects of acute administration of phencyclidine (PCP) on the steady state levels of methionine-enkephalinin discrete brain areas were investigated in mice. The methionine-enkephalin levels in the medulla oblongata-pons and the midbrain were decreased by the administration of PCP. However, PCP induced no change of the methionine-enkephalin levels in other brain areas at the dose range of 5-20 mg/kg. These results suggest that the pharmacological effects of PCP may involve changes in enkephalinergic neuronal activity.
AB - The effects of acute administration of phencyclidine (PCP) on the steady state levels of methionine-enkephalinin discrete brain areas were investigated in mice. The methionine-enkephalin levels in the medulla oblongata-pons and the midbrain were decreased by the administration of PCP. However, PCP induced no change of the methionine-enkephalin levels in other brain areas at the dose range of 5-20 mg/kg. These results suggest that the pharmacological effects of PCP may involve changes in enkephalinergic neuronal activity.
UR - http://www.scopus.com/inward/record.url?scp=0020414805&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020414805&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(82)90325-9
DO - 10.1016/0014-2999(82)90325-9
M3 - Article
C2 - 7160437
AN - SCOPUS:0020414805
VL - 86
SP - 271
EP - 273
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 2
ER -